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Dergiler / Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi / 2026 / Cilt: 10 Sayı: 1

Hidrazin ve Isatinlerden Elde Edilen Bazı Yeni Schiff Bazlarının Sentezi, Karakterizasyonu ve Antioksidan Özellikleri

Preparation, Characterization, and Antioxidant Features of Some New Schiff Bases Derived from Isatins and Hydrazine

Halit Muğlu(KASTAMONU ÜNİVERSİTESİ)0000-0001-8306-2378
Hasan Yakan(ONDOKUZ MAYIS ÜNİVERSİTESİ)0000-0002-4428-4696
Sayfa
439–447
Yayın Tarihi
2020-03-01
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Sonuçlar, hesaplanan IC50 (yarı maksimum inhibitör derişim) değerleri ile verilmiştir.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Yeni schiff bazlı isatinler, hidrazin, 5-sübstitütentli isatinler ve çeşitli aldehitlerin etil alkolde geri soğutucu altındaki tepkimesi sonucu elde edilmiştir.
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Temel Bulgular & Veri:Sentezlenen bileşiklerin yapısı IR, 13C NMR, 1H NMR spektroskopik veriler ve elementel analiz sonuçlar ile aydınlatılmıştır.
💡
Sonuç & Katkı:Sonuçlar, hesaplanan IC50 (yarı maksimum inhibitör derişim) değerleri ile verilmiştir.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Schiff baz · isatin · antioxidant özellikler

Özet

Yeni schiff bazlı isatinler, hidrazin, 5-sübstitütentli isatinler ve çeşitli aldehitlerin etil alkolde geri soğutucu altındaki tepkimesi sonucu elde edilmiştir. Sentezlenen bileşiklerin yapısı IR, 13C NMR, 1H NMR spektroskopik veriler ve elementel analiz sonuçlar ile aydınlatılmıştır. Sentezlenen bileşiklerin antioksidan aktivite testleri 2,2-difenil-1-pikril hidrazil (DPPH) radikal giderme yöntemi ile yapılmıştır. Sonuçlar, hesaplanan IC50 (yarı maksimum inhibitör derişim) değerleri ile verilmiştir.

Abstract

New isatins based on Schiff bases were prepared from hydrazine, 5-substituted isatins, and aldehydes under reflux in ethanol. The structures of the synthesized compounds were elucidated by using IR, 13C NMR, 1H NMR spectroscopy and elemental analysis. All the compounds were tested in vitro antioxidant activity with free radical scavenging method using by 1,1-diphenyl-2-picryl hydrazyl (DPPH). The results were given with calculated IC50 values.

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Bu Makaleye Atıf Yap

Muğlu, H., Yakan, H. (2020). Hidrazin ve Isatinlerden Elde Edilen Bazı Yeni Schiff Bazlarının Sentezi, Karakterizasyonu ve Antioksidan Özellikleri. Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi, Cilt: 10 Sayı: 1, 439–447. https://doi.org/10.21597/jist.589004

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