KaydedilenlerDerginizi ekleyin

Dergiler / Celal Bayar Üniversitesi Fen Bilimleri Dergisi / 2021 / Cilt: 17 - Sayı: 1

Newly Axial Silicon(IV) Phthalocyanine Photosensitizer: Design, Synthesis and Photochemical Properties

Gülçin EKİNEKER
Hülya YANIK
Sayfa
11–16
Yayın Tarihi
2020-12-30
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

In this study, we found that axial substituted silicon(IV) phthalocyanine (4) may be promising PDT agent.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Used as photosensitizer in photodynamic therapy, phthalocyanines exhibit their long wavelength absorption and the ability to produce high singlet oxygen for tumor destruction with 650 to 800 nm fluorescence.Phthalocyanines with their long wavelength absorption and fluorescence from 650 to 800 nm exhibit their ability to produce high singlet oxygen for the destruction of tumors.
📊
Temel Bulgular & Veri:In this study, new axial substituted silicon(IV) phthalocyanine (4) was synthesized.
💡
Sonuç & Katkı:In this study, we found that axial substituted silicon(IV) phthalocyanine (4) may be promising PDT agent.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Axial · silicon(IV) phthalocyanine · photosensitizer

Abstract

Used as photosensitizer in photodynamic therapy, phthalocyanines exhibit their long wavelength absorption and the ability to produce high singlet oxygen for tumor destruction with 650 to 800 nm fluorescence.Phthalocyanines with their long wavelength absorption and fluorescence from 650 to 800 nm exhibit their ability to produce high singlet oxygen for the destruction of tumors. In this study, new axial substituted silicon(IV) phthalocyanine (4) was synthesized. Unsubstituted dichlorosilicon phthalocyanine was synthesized from 1,3-diiminoisoindoline via cyclotetramerization. The axial substitution reaction was carried out using dichlorosilicon(IV) phthalocyanine and excess of 2-methoxyethanol. Structural characterization of this new axial-substituted silicon(IV) phthalocyanine by IR, mass, and UV-Vis spectroscopy were performed. Photochemical properties were investigated for cancer therapy. In this study, we found that axial substituted silicon(IV) phthalocyanine (4) may be promising PDT agent.

🔖

Bu Makaleye Atıf Yap

EKİNEKER, G., YANIK, H. (2020). Newly Axial Silicon(IV) Phthalocyanine Photosensitizer: Design, Synthesis and Photochemical Properties. Celal Bayar Üniversitesi Fen Bilimleri Dergisi, Cilt: 17 - Sayı: 1, 11–16. https://ajindex.com/articles/116477

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (11)

  1. Ekineker, G, Nguyen, C, Bayır, S, Dominguez Gil, S, İşci, Ü, Daurat, M, Godefroy, A, Raehm, L, Charnay, C, Oliviero, E, Ahsen, V, Gary-Bobo, M, Durand, J-O, and Dumoulin, F. 2019. Phthalocyanine-based mesoporous organosilica nanoparticles: NIR photodynamic efficiency and siRNA photochemical internalization, Chemical Communications; 55, 11619-11622
  2. Macdonald, I J, and Dougherty, T. J. 2001. Basic principles of photodynamic therapy, Journal of Porphyrins and Phthalocyanines 5, 105-129
  3. Tarhouni, M, Durand, D, Önal, E, Aggad, D, İşci, Ü, Ekineker, G, Brégier, F, Jamoussi, B, Sol, V, Gary-Bobo, M, and Dumoulin, F. 2018. Triphenylphosphonium-substituted phthalocyanine: Design, synthetic strategy, photoproperties and photodynamic activity, Journal of Porphyrins and Phthalocyanines; 22, 552-561
  4. Hopper, C. 2000. Photodynamic therapy: a clinical reality in the treatment of cancer, The lancet oncology; 1, 212-219
  5. Plaetzer, K, Krammer, B, Berlanda, J, Berr, F, and Kiesslich, T. 2009. Photophysics and photochemistry of photodynamic therapy: fundamental aspects, Lasers Med Sci; 24, 259-268
  6. Lo, P-C, Rodríguez-Morgade, M S, Pandey, R -K, Ng, D. K. P, Torres, T, and Dumoulin, F. 2020. The unique features and promises of phthalocyanines as advanced photosensitisers for photodynamic therapy of cancer, Chemical Society Reviews
  7. Bartlett, M-A, Mark, K, and Sundermeyer, J. 2018. Synthesis, spectroscopy and singlet oxygen quantum yield of a non-aggregating hexadecamethyl-substituted phthalocyanine silicon (IV) derivative, Inorganic Chemistry Communications; 98, 41-43
  8. Barut, B, Demirbas, U, Ozel, A, and Kantekin, H. 2017. Novel water soluble morpholine substituted Zn(II) phthalocyanine: Synthesis, characterization, DNA/BSA binding, DNA photocleavage and topoisomerase I inhibition, International journal of biological macromolecules; 105, 499-508
  9. Skupin-Mrugalska, P, Szczolko, W, Gierlich, P, Konopka, K, Goslinski, T, Mielcarek, J and Düzgüneş, N. 2018. Physicochemical properties of liposome-incorporated 2-(morpholin-4-yl) ethoxy phthalocyanines and their photodynamic activity against oral cancer cells, Journal of Photochemistry and Photobiology A: Chemistry; 353, 445-457
  10. Baş, H, Biyiklioglu, Z. 2018. Synthesis and electropolymerization properties of axially disubstituted silicon phthalocyanines bearing carbazole units, Inorganica Chimica Acta; 483, 79-86
  11. Goksel, M, Biyiklioglu, Z, Durmus, M. 2017. The water soluble axially disubstituted