SavedAdd your journal

Journals / Journal of Agriculture / 2023 / Cilt: 6 Sayı: 1

Synthesis, Characterization of Biogenic Copper Nanoparticles and Their Therapeutic Activity

Yılmaz KOÇAK
Hamdullah SEÇKİN
Pages
26–35
Publication Date
2023-06-30
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These results showed that Cu NPs may have a selective effect against drug-resistant bacteria as an alternative agent to pharmaceutical applications.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Green synthesis of copper nanoparticles (Cu NPs) is an economical, environmentally friendly and non-toxic approach that has been the subject of research in health and industry.
📊
Key Findings & Data:Copper metal was reduced by reacting with the seed extract and reached the maximum peak at 385 nm in the UV-vis spectra, confirming the surface plasmon resonance.
💡
Conclusion & Impact:These results showed that Cu NPs may have a selective effect against drug-resistant bacteria as an alternative agent to pharmaceutical applications.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Antibacterial · Antioxidant · Copper nanoparticles

Abstract

Green synthesis of copper nanoparticles (Cu NPs) is an economical, environmentally friendly and non-toxic approach that has been the subject of research in health and industry. Therefore, in this study, Cu NPs were synthesized using Pimpinella anisum (P.anisum) seed extract and their pharmacological activities were evaluated. Characterization of Cu NPs was performed by UV-vis, FT-IR and SEM-EDX analyses. Copper metal was reduced by reacting with the seed extract and reached the maximum peak at 385 nm in the UV-vis spectra, confirming the surface plasmon resonance. FT-IR spectroscopy showed the participation of phytochemical components in P. anisum in the synthesis. SEM analysis determined that the size of the biosynthesized nanoparticles is 10-20 nm in diameter and has a spherical structure. Strong signals of copper metal were confirmed by EDX analysis. The therapeutic effect of Cu NPs was evaluated by antioxidant and antibacterial assays. The DPPH radical scavenging activity IC50 inhibition values of Cu NPs were better than the seed extract and exhibited strong antioxidant activity. Antibacterial activity was performed by the disk diffusion method and Cu NPs were more effective against gram-positive bacteria. It had the highest zone diameter (18.0±2.8 mm), especially on Bacillus subtilis bacteria. These results showed that Cu NPs may have a selective effect against drug-resistant bacteria as an alternative agent to pharmaceutical applications. This study showed that P. anisum seed extract-mediated bioconjugation of Cu NPs can be done simply, quickly and cost-effectively. As a result, Cu NPs should be supported by more detailed in vivo studies to create antioxidant and antibacterial agents.

🔖

Cite This Article

KOÇAK, Y., SEÇKİN, H. (2023). Synthesis, Characterization of Biogenic Copper Nanoparticles and Their Therapeutic Activity. Journal of Agriculture, Cilt: 6 Sayı: 1, 26–35. https://ajindex.com/articles/952469

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (8)

  1. Abbasi, A., Khojasteh, H., Hamadanian, M., & Salavati-Niasari, M. (2016). Synthesis of CoFe2O4 nanoparticles and investigation of the temperature, surfactant, capping agent and time effects on the size and magnetic properties. Journal of Materials Science: Materials in Electronics, 27(5), 4972–4980. https://doi.org/10.1007/S10854-016-4383-Y
  2. Adewale Akintelu, S., Kolawole Oyebamiji, A., Charles Olugbeko, S., & Felix Latona, D. (2021). Green chemistry approach towards the synthesis of copper nanoparticles and its potential applications as therapeutic agents and environmental control. Current Research in Green and Sustainable Chemistry, 4(September), 100176. https://doi.org/10.1016/j.crgsc.2021.100176
  3. Alkhulaifi, M. M., Alshehri, J. H., Alwehaibi, M. A., Awad, M. A., Al-Enazi, N. M., Aldosari, N. S., Hatamleh, A. A., & Abdel-Raouf, N. (2020). Green synthesis of silver nanoparticles using Citrus limon peels and evaluation of their antibacterial and cytotoxic properties. Saudi Journal of Biological Sciences, 27(12), 3434–3441. https://doi.org/10.1016/J.SJBS.2020.09.031
  4. Amaliyah, S., Pangesti, D. P., Masruri, M., Sabarudin, A., & Sumitro, S. B. (2020). Green synthesis and characterization of copper nanoparticles using Piper retrofractum Vahl extract as bioreductor and capping agent. Heliyon, 6(8), e04636. https://doi.org/10.1016/j.heliyon.2020.e04636
  5. Asghar, M. A., & Asghar, M. A. (2020). Green synthesized and characterized copper nanoparticles using various new plants extracts aggravate microbial cell membrane damage after interaction with lipopolysaccharide. International Journal of Biological Macromolecules, 160, 1168–1176. https://doi.org/10.1016/J.IJBIOMAC.2020.05.198
  6. Bazancir, N., & Meydan, I. (2022). Characterization of Zn nanoparticles of Platonus orientalis plant, investigation of DPPH radical extinquishing and antimicrobial activity. Eastern Journal of Medicine, 27(4). https://doi.org/10.5505/ejm.2022.34392
  7. Cho, K. H., Park, J. E., Osaka, T., & Park, S. G. (2005). The study of antimicrobial activity and preservative effects of nanosilver ingredient. Electrochimica Acta, 51(5), 956–960. https://doi.org/10.1016/J.ELECTACTA.2005.04.071
  8. Das, P. E., Abu‐Yousef, I. A., Majdalawieh, A. F., Narasimhan, S., & Poltronieri, P. (2020). Green Synthesis of Encapsulated Copper Nanoparticles Using a Hydroalcoholic Extract of Moringa oleifera Leaves and Assessment of Their Antioxidant and Antimicrobial Activities. Molecules, 25(3), 555. https://doi.org/10.3390/molecule