SavedAdd your journal

Journals / Journal of Agricultural Production / 2023 / Cilt: 4 Sayı: 1

Exopolysaccharide from Rhodococcus pyridinivorans ZZ47 Strain: Evaluation of Biological Activity and Toxicity

Aylin TAŞKAYA
Nur CEYHAN GÜVENSEN
Cem GÜLER
Ebru ŞANCI
Ülkü KARABAY
Pages
63–71
Publication Date
2023-06-30
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion, the isolated EPS has antioxidant activity with no genotoxicity and the biological activities of the polymer indicated that it may be suitable for use in different sectors and industrial applications.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Microbial polysaccharides are extracellular polymeric macromolecules excreted in microorganisms.
📊
Key Findings & Data:The purpose of the study was to evaluate biological activity and potential toxicity of EPS from Rhodococcus pyridinivorans ZZ47 strain isolated from nature.
💡
Conclusion & Impact:In conclusion, the isolated EPS has antioxidant activity with no genotoxicity and the biological activities of the polymer indicated that it may be suitable for use in different sectors and industrial applications.
🔬Design:Research Article
📍Scope:2000 Verileri
⚙️Variables:Acute toxicity · Anti-angiogenic activity · Antibiofilm activity

Abstract

Microbial polysaccharides are extracellular polymeric macromolecules excreted in microorganisms. These are widely used in food, cosmetic and pharmaceutical industries. One of them, exopolysaccharides (EPS), plays important role against the factors such as phage attack, antibiotics, toxic compounds or osmotic stress. Recently, this natural polymer has received great attention due to their therapeutic potential. The purpose of the study was to evaluate biological activity and potential toxicity of EPS from Rhodococcus pyridinivorans ZZ47 strain isolated from nature. EPS has no genotoxic effect on Salmonella typhimurium TA98, TA102, and TA1537 strains by Ames Test. No death occurred with single dose oral toxicity test of EPS and LD50 value of it is calculated by >2000 mg/kg in mice. The EPS showed antibiofilm activity on different bacteria. In addition, EPS demonstrated dose-dependent anti-angiogenic properties by HET-CAM test. In conclusion, the isolated EPS has antioxidant activity with no genotoxicity and the biological activities of the polymer indicated that it may be suitable for use in different sectors and industrial applications.

🔖

Cite This Article

TAŞKAYA, A., GÜVENSEN, N. C., GÜLER, C., ŞANCI, E., KARABAY, Ü. (2023). Exopolysaccharide from Rhodococcus pyridinivorans ZZ47 Strain: Evaluation of Biological Activity and Toxicity. Journal of Agricultural Production, Cilt: 4 Sayı: 1, 63–71. https://ajindex.com/articles/948008

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (8)

  1. Abdel-Wahab, B. A., F. Abd El-Kareem, H., Alzamami, A., A. Fahmy, C., H. Elesawy, B., Mostafa Mahmoud, M., & M. Saied, E. (2022). Novel exopolysaccharide from marine bacillus subtilis with broad potential biological activities: Insights into antioxidant, anti-inflammatory, cytotoxicity, and anti-alzheimer activity. Metabolites, 12(8), 715. https://doi.org/10.3390/metabo12080715
  2. Ahmad, S., Tanweer, M. S., Mir, T. A., Alam, M., Ikram, S., & Sheikh, J. N. (2023). Antimicrobial gum based hydrogels as adsorbents for the removal of organic and inorganic pollutants. Journal of Water Process Engineering, 51, 103377. https://doi.org/10.1016/j.jwpe.2022.103377 Al‐Husein, B., Abdalla, M., Trepte, M., DeRemer, D. L., & Somanath, P. R., (2012). Antiangiogenic therapy for cancer: An update. Pharmacotherapy, 32(12), 1095-1111. https://doi.org/10.1002/phar.1147
  3. Angelin, J., & Kavitha, M. (2020). Exopolysaccharides from probiotic bacteria and their health potential. International Journal of Biological Macromolecules, 162, 853-865. https://doi.org/10.1016/j.ijbiomac.2020.06.190
  4. Barcelos, M. C., Vespermann, K. A., Pelissari, F. M., & Molina, G. (2020). Current status of biotechnological production and applications of microbial exopolysaccharides. Critical Reviews in Food Science and Nutrition, 60(9), 1475-1495. https://doi.org/10.1080/10408398.2019.1575791
  5. Bello, K., Sarojini, B. K., Narayana, B., Rao, A., & Byrappa, K. (2018). A study on adsorption behavior of newly synthesized banana pseudo-stem derived superabsorbent hydrogels for cationic and anionic dye removal from effluents. Carbohydrate Polymers, 181, 605–615. https://doi.org/10.1016/j.carbpol.2017.11.106
  6. Botelho, P. S., Maciel, M. I., Bueno, L. A., Maria de Fátima, F. M., Marques, D. N., & Silva, T. M. S. (2014). Characterisation of a new exopolysaccharide obtained from of fermented kefir grains in soymilk. Carbohydrate Polymers, 107, 1-6. https://doi.org/10.1016/j.carbpol.2014.02.036
  7. Castellane, T. C. L., Campanharo, J. C., Colnago, L. A., Coutinho, I. D., Lopes, É. M., Lemos, M. V. F., & de Macedo Lemos, E. G. (2017). Characterization of new exopolysaccharide production by Rhizobium tropici during growth on hydrocarbon substrate. International Journal of Biological Macromolecules, 96, 361-369. https://doi.org/10.1016/j.ijbiomac.2016.11.123
  8. Chaisuwan, W., Jantanasakulwong, K., Wangtueai, S., Phimolsiripol, Y., Chaiyaso, T., Techapun, C., Phongthai, S., You, S., Regenstein, J. M., & Seesuriyachan, P. (2020). Microbi