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Journals / Çocuk Dergisi / 2026 / Cilt: 23 Sayı: 1

Current Approach to The Treatment of Infantile Hemangioma

İnfantil Hemanjiomların Tedavisinde Güncel Yaklaşımlar

Aybüke Doğan(İstanbul Üniversitesi, İstanbul Tıp Fakültesi, İstanbul, Türkiye)0000-0001-5014-3737
Emine Ecem Aydoğan(İstanbul Üniversitesi, İstanbul Tıp Fakültesi, İstanbul, Türkiye)0000-0003-2081-9227
Hikmet Gülşah Tanyıldız(İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Çocuk Hematoloji Onkoloji Bilim Dalı, İstanbul, Türkiye)0000-0002-0455-2078
Pages
89–94
Publication Date
2023-03-27
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this review, we aimed to discuss the efficacy and safety of propranolol in light of current data, including studies at the molecular level.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Infantile hemangioma (IH) is the most common benign vascular tumor of the infantile period.
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Key Findings & Data:The most accepted theory suggests that maternal hypoxic stress leads to the production of hypoxia inducible factor-1 alpha (HIF-1a), which leads to an increased production of vascular endothelial growth factor (VEGF), GLUT-1, and insulin-like growth factor-2, which induces endothelial cell proliferation.
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Conclusion & Impact:In this review, we aimed to discuss the efficacy and safety of propranolol in light of current data, including studies at the molecular level.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:İnfantil hemanjiom · propranolol · topikal timolol

Abstract

Infantile hemangioma (IH) is the most common benign vascular tumor of the infantile period. Although the etiopathology of IH is not well-known, two primary theories exist. The most accepted theory suggests that maternal hypoxic stress leads to the production of hypoxia inducible factor-1 alpha (HIF-1a), which leads to an increased production of vascular endothelial growth factor (VEGF), GLUT-1, and insulin-like growth factor-2, which induces endothelial cell proliferation. The second theory suggests that endothelial cell proliferation is induced by embolization of placental tissue. Propranolol is a nonselective beta-adrenergic receptor blocker which is used in current mainstay therapy for IH. In this review, we aimed to discuss the efficacy and safety of propranolol in light of current data, including studies at the molecular level.

Özet

İnfantil hemanjiyom (İH), süt çocukluğu döneminin en sık görülen benign vasküler tümörüdür. Etyopatogenezi hakkında kesin bir bilgi olmamakla birlikte iki temel teoriden bahsedilebilir. Bu teorilerden en çok kabul göreni maternal hipoksik strese bağlı hipoksiyle indüklenen faktör 1 alpha (HIF1-α) artışının VEGF, GLUT1 ve insülin benzeri büyüme faktörü-2 düzeylerini arttırması ve bunun sonucunda endotelyal hücre proliferasyonunun indüklenmesidir. İkinci teori ise plasental doku embolizasyonu nedeniyle ortaya çıkan endotelyal hücre proliferasyonudur. Propranolol İH’nin güncel medikal tedavisinde birinci basamakta kullanılan bir non selektif beta adrenerjik reseptör blokeridir. Derlememizde propranololün etkinliği ve güvenilirliğini moleküler düzeyde yapılan araştırmaları da göz önünde bulundurarak güncel veriler ışığında sunmayı planladık

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Cite This Article

Doğan, A., Aydoğan, E. E., Tanyıldız, H. G. (2023). Current Approach to The Treatment of Infantile Hemangioma. Çocuk Dergisi, Cilt: 23 Sayı: 1, 89–94. https://doi.org/10.26650/jchild.2023.878287

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