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Journals / Türk Psikiyatri Dergisi / 2005 / Cilt: 16 - Sayı: 1

The diagnostic validity of screening tests and laboratory markers in alcohol use disorders

Alkol kullanım bozukluklarında tarama testleri ve laboratuvar belirteçlerinin tanısal etkinliği

Selami GÜL
YILDIZ AKVARDAR
Gültekin TAŞ
Pınar TUNCEL
Pages
3–12
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: According to the results of this study, the marker that has the highest validity is GGT, while AUDIT and CAGE are the best screening tests.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: To determine the validity of screening tests and markers suggested in the early detection of alcohol use disorders.
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Key Findings & Data:Method: Male patients aged 20-65 were recruited from a psychiatry clinic.
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Conclusion & Impact:Conclusion: According to the results of this study, the marker that has the highest validity is GGT, while AUDIT and CAGE are the best screening tests.
🔬Design:Lab & Field Experiment
📍Scope:Comprehensive Sample
⚙️Variables:gamma-glutamiltranferaz · Zihinsel bozuklukların manuel tanı ve istatistiği · Alkol bağımlılığı bozuklukları

Abstract

Objective: To determine the validity of screening tests and markers suggested in the early detection of alcohol use disorders. Method: Male patients aged 20-65 were recruited from a psychiatry clinic. They had been consuming alcohol at least once a week. They were not drug users and had no other diseases that affected the markers mentioned in this study. According to the DSM-IV diagnostic criteria, the diagnostic validity of screening tests [Michigan Alcoholism Screening Test (MAST), CAGE (Cut down, Annoyed, Guilty, Eye-opener), Alcohol Use Disorders Identification Test (AUDIT)] and markers [Mean corpuscular volume (MCV), aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyltransferase (GGT), carbohydrate-deficient transferrin (CDT)] was investigated in alcohol dependent patients (n=29), alcohol abusers (n=28) and social drinkers (n=28). Results: For the diagnosis of dependence, the sensitivity and specificity of the tests were respectively 69% and 100% for GGT, 41% and 93% for CDT, 100% and 57% for MAST, 97% and 86% for CAGE, and 100% and 75% for AUDIT. For the diagnosis of abuse, the sensitivity and specificity of the tests were respectively 32% and 100% for GGT, 32% and 93% for CDT, 86% and 57% for MAST, 75% and 85.7% for CAGE, and 89% and 75% for AUDIT. The widest area under the ROC curve belonged to GGT as a marker and AUDIT as a screening test. Conclusion: According to the results of this study, the marker that has the highest validity is GGT, while AUDIT and CAGE are the best screening tests.

Özet

Amaç: Alkol kullanım bozukluklarının erken saptanabilmesi için önerilen tarama testleri ve laboratuvar belirteçlerinin geçerliliklerinin belirlenmesi amaçlanmıştır. Yöntem: Psikiyatri kliniği hastalarından haftada en az bir kez alkol kullanan, belirteçlerin serum düzeyini etkileyebi-lecek hastalığı ve ilaç kullanımı olmayan, 20-65 yaşlarındaki erkek hastalar DSM-IV tanı kriterlerine göre alkol bağımlılığı (n=29), kötüye kullanımı (n=28), kontrol (n=28) grupları oluşturularak tarama testlerinin [Michigan Alkolizm Tarama Testi (MATT), CAGE ve Alkol Kullanım Bozuklukları Tanıma Testi (AKBTT)] ve laboratuvar belirteçlerinin [ortalama eritrosit hacmi (MCV), aspartat aminotransferaz (AST), alanin aminotransferaz (ALT), gama-glutamiltrans-feraz (GGT) ve karbonhidrattan yoksun transferrin (CDT)] tanısal geçerlilikleri araştırıldı. Bulgular: Testlerin alkol bağımlılığının tanısında duyarlılık ve özgüllükleri GGT için % 69 ve % 100, CDT için % 41 ve % 93, MATT için % 100 ve % 57, CAGE için % 97 ve % 86, AKBTT için % 100 ve % 75 bulundu. Alkol kötüye kullanımı tanısında duyarlılık ve özgüllükleri GGT için % 32 ve % 100, CDT için % 32 ve % 93, MATT için % 86 ve % 57, CAGE için % 75 ve % 86, AKBTT için % 89 ve % 75 bulundu. CAGE+GGT+MCV kombinasyonunun geçerlik göster-geleri % 80'in üzerinde bulundu. ROC eğrisi altında en geniş alanları belirteçler içinde GGT, tarama testleri içinde AKBTT oluşturdu. Sonuç: Araştırma sonuçlarına göre en yüksek tanısal geçerliğe belirteçlerden GGT, tarama testlerinden CAGE ve AKBTT sahiptir.

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Cite This Article

GÜL, S., AKVARDAR, Y., TAŞ, G., TUNCEL, P. (2005). The diagnostic validity of screening tests and laboratory markers in alcohol use disorders. Türk Psikiyatri Dergisi, Cilt: 16 - Sayı: 1, 3–12. https://ajindex.com/articles/92970

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