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Journals / Hittite Journal of Science and Engineering / 2021 / Cilt: 8 Sayı: 3

Evaluation of controlled hydroxychloroquine releasing performance from calcium-alginate beads

Canan ARMUTCU
Sena PİŞKİN
Pages
255–263
Publication Date
2021-09-29
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Kinetic model, Korsmeyer-Peppas was applied to model the HCQ release kinetic of alginate beads, which corresponded to non-Fickian transport mechanism.

📌 3 Key Takeaways

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Objective & Hypothesis:The aim of this study was to develop an effective controlled drug delivery system based on alginate beads for the treatment of autoimmune diseases such as Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE).
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Key Findings & Data:The release studies from alginate beads prepared in various drug dose were carried out in the aqueous solutions at different pH (5–8) and temperature (4-37oC).
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Conclusion & Impact:Kinetic model, Korsmeyer-Peppas was applied to model the HCQ release kinetic of alginate beads, which corresponded to non-Fickian transport mechanism.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Calcium-alginate beads · hydroxychloroquine · drug delivery

Abstract

The aim of this study was to develop an effective controlled drug delivery system based on alginate beads for the treatment of autoimmune diseases such as Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE). The present study describes the drug delivery systems to control the effective uses of hydroxychloroquine (HCQ) by Ca-alginate beads. The characterization techniques were employed to evaluate the physicochemical properties as scanning electron microscopy (SEM), swelling test (S), hydrolytic degradation (weight loss, WL) and Fourier transform infrared-attenuated total reflection (FTIR-ATR). The release studies from alginate beads prepared in various drug dose were carried out in the aqueous solutions at different pH (5–8) and temperature (4-37oC). The approximately half-amount of HCQ in HCQ-AB3 was released in 12 h and about 84.38% was released within 8 days. Kinetic model, Korsmeyer-Peppas was applied to model the HCQ release kinetic of alginate beads, which corresponded to non-Fickian transport mechanism.

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Cite This Article

ARMUTCU, C., PİŞKİN, S. (2021). Evaluation of controlled hydroxychloroquine releasing performance from calcium-alginate beads. Hittite Journal of Science and Engineering, Cilt: 8 Sayı: 3, 255–263. https://ajindex.com/articles/929529

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