Journals / Arşiv Kaynak Tarama Dergisi / 2003 / Cilt: 12 Sayı: 3

The Role of c-erbB-2 Oncogene in Breast Carcinoma

Meme Karsinomunda c-erbB-2 Onkogeninin Yeri

Pages
1–1
Publication Date
2003-09-01
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this study, we discuss the prognostic role of c-erbB-2 oncoprotein overexpression in breast carcinoma with and without other parameters on the base of literature.

📌 3 Key Takeaways

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Objective & Hypothesis:Several factors have been identified in breast carcinoma which affect the biologic behavior, therapy and the prognosis of the tumor.
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Key Findings & Data:Among these, c-erbB-2 (HER-2/neu) oncogene encodes a transmembrane tyrosine kinase receptor with extensive homology to the Epidermal Growth Factor receptor.
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Conclusion & Impact:In this study, we discuss the prognostic role of c-erbB-2 oncoprotein overexpression in breast carcinoma with and without other parameters on the base of literature.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Meme Karsinomu · c-erbB-2 Onkogen · c-erbB-2 Oncogene

Abstract

Several factors have been identified in breast carcinoma which affect the biologic behavior, therapy and the prognosis of the tumor. Among these, c-erbB-2 (HER-2/neu) oncogene encodes a transmembrane tyrosine kinase receptor with extensive homology to the Epidermal Growth Factor receptor. In this study, we discuss the prognostic role of c-erbB-2 oncoprotein overexpression in breast carcinoma with and without other parameters on the base of literature.

Özet

Meme karsinomunda, tümörün biyolojik davranışını, tedavi ve prognozunu belirleyen çeşitli parametreler tanımlanmıştır. Bunların içerisinde c-erbB-2 (HER-2/neu), Epidermal Büyüme Faktör reseptörüne benzeyen, hücre membranında tirozin kinaz reseptörünü kodlayan bir onkogendir. Bu çalışmada, meme karsinomlarında, c-erbB-2 onkoprotein ekspresyonunun, tek başına ve diğer parametreler ile birlikte prognostik önemi literatür eşliğinde tartışılmıştır.

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Cite This Article

ERDOĞAN, Ş., ERGİN, M., TUNCER, İ. (2003). The Role of c-erbB-2 Oncogene in Breast Carcinoma. Arşiv Kaynak Tarama Dergisi, Cilt: 12 Sayı: 3, 1–1. https://ajindex.com/articles/924519

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