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Journals / KTO Karatay Üniversitesi Sağlık Bilimleri Dergisi / 2023 / Cilt: 4 Sayı: 1

A case report of Glanzman Thrombasthenia with anterior mediastinal hematoma and Factor V Leiden mutation

Ön mediastende hematomu olan ve Faktör V Leiden mutasyonu bulunan Glanzman Trombastenili bir olgu sunumu

Hüseyin TOKGÖZ
Ümran ÇALIŞKAN
Tuğçe DURAN
Kaniye Zeynep ÇALIŞKAN SAK
Pages
17–22
Publication Date
2023-04-28
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We present this case in which Factor V and Glanzmann thrombasthenia with hematoma in the anterior mediastinum are rarely seen together.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Glanzmann thrombasthenia (GT) is an autosomal recessive disease associated with platelet aggregation dysfunction with normal platelet count, causing bleeding diathesis.
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Key Findings & Data:GT is characterized by decreased levels or decreased function of the glycoprotein IIb-IIIa (GPIIb-IIIa) complex and therefore results in an increased tendency to bleeding as the aggregation phase of primary hemostasis cannot be sufficiently formed.
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Conclusion & Impact:We present this case in which Factor V and Glanzmann thrombasthenia with hematoma in the anterior mediastinum are rarely seen together.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Factor V Leiden · Glanzmann trombasteni · Hematom

Abstract

Glanzmann thrombasthenia (GT) is an autosomal recessive disease associated with platelet aggregation dysfunction with normal platelet count, causing bleeding diathesis. GT is characterized by decreased levels or decreased function of the glycoprotein IIb-IIIa (GPIIb-IIIa) complex and therefore results in an increased tendency to bleeding as the aggregation phase of primary hemostasis cannot be sufficiently formed. Factor V Leiden mutation is a genetic mutation predisposing to thrombophilia. We present this case in which Factor V and Glanzmann thrombasthenia with hematoma in the anterior mediastinum are rarely seen together.

Özet

Glanzmann trombasteni (GT), normal trombosit sayısı ile trombosit agregasyon disfonksiyonu ile ilişkili, kanama diyatezi oluşturan otozomal resesif geçişli bir hastalıktır. GT, glikoprotein IIb-IIIa (GPIIb-IIIa) kompleksinin azalmış seviyeleri veya azalmış işlevi ile karakterize edilir ve bu nedenle, birincil hemostazın kümelenme fazı yeterince oluşturulamadığından artan kanama eğilimi ile sonuçlanır. Faktör V Leiden mutasyonu, trombofili için yatkınlık oluşturan genetik bir mutasyondur. Faktör V ve Glanzmann trombastisinin ön mediastende hematom ile birlikte nadiren birlikte görüldüğü bu olguyu sunuyoruz.

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Cite This Article

TOKGÖZ, H., ÇALIŞKAN, Ü., DURAN, T., SAK, K. Z. Ç. (2023). A case report of Glanzman Thrombasthenia with anterior mediastinal hematoma and Factor V Leiden mutation. KTO Karatay Üniversitesi Sağlık Bilimleri Dergisi, Cilt: 4 Sayı: 1, 17–22. https://ajindex.com/articles/909856

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