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Journals / Türk Psikiyatri Dergisi / 2007 / Cilt: 18 - Sayı: 3

Therapeutic response to plasmapheresis in four cases with obsessive-compulsive disorder and tic disorder triggered by streptococcal infections

Streptokok enfeksiyonu ile ilişkili OKB ve tik bozukluğu olan dört olguda plazmaferez tedavisine yanıt

LÜTFULLAH BEŞİROĞLU
MEHMET YÜCEL AĞARGÜN
Özgür ÖZBEBİT
Mehmet SÖZEN
İmdat DİLEK
MUSTAFA GÜLEÇ
Pages
270–276
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this paper, we discuss the effect of plasmapheresis treatment in 4 adult cases of obsessive-compulsive disorder and tic disorder triggered by streptococcal infections.

📌 3 Key Takeaways

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Objective & Hypothesis:The acronym PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections) has been assigned to a subgroup of patients experiencing pediatric onset obsessive-compulsive symptoms and tics as a result of autoimmune response to group A β-hemolytic streptococcal infection.
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Key Findings & Data:In cases with severe neuropsychiatric symptoms, the use of treatment strategies that interrupt the autoimmune process responsible for the pathogenesis of PANDAS, such as therapeutic plasmapheresis or intravenous immunoglobulin, has been proposed.
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Conclusion & Impact:In this paper, we discuss the effect of plasmapheresis treatment in 4 adult cases of obsessive-compulsive disorder and tic disorder triggered by streptococcal infections.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Streptococcus pyogenes · Ergen · Erişkin

Abstract

The acronym PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections) has been assigned to a subgroup of patients experiencing pediatric onset obsessive-compulsive symptoms and tics as a result of autoimmune response to group A β-hemolytic streptococcal infection. It has been hypothesized that an immune process initiated by infection affects the basal ganglia and causes neuropsychiatric symptoms. In cases with severe neuropsychiatric symptoms, the use of treatment strategies that interrupt the autoimmune process responsible for the pathogenesis of PANDAS, such as therapeutic plasmapheresis or intravenous immunoglobulin, has been proposed. In this paper, we discuss the effect of plasmapheresis treatment in 4 adult cases of obsessive-compulsive disorder and tic disorder triggered by streptococcal infections.

Özet

Streptokok enfeksiyonun yol açtığı çocukluk çağı oto-immün nöropsikiyatrik bozukluklar (PANDAS) tanımı, A grubu-beta hemolitik streptokok enfeksiyonu sonrası oto-immün tepkinin bir sonucu olarak, çocukluk çağında ortaya çıkan obsesif-kompulsif belirtiler ve tikleri bulunan hastaları tanımlamaktadır. Bu hastalarda enfeksiyon tarafından başlatılan oto-immün sürecin bazal gangliyonları etkilediği ve nöropsikiyatrik belirtilere neden olduğu öne sürülmektedir. Şiddetli nöropsikiyatrik belirtileri olan olgularda, PANDAS'ın patogenezinden sorumlu oto-immün süreci kesintiye uğratan, plazmaferez ve immunglobulin tedavisi gibi uygulamaların kullanılması önerilmektedir. Bu yazıda streptokok enfeksiyonu ile ilişkili OKB ve tik bozukluğu olan dört erişkin olguda plazmaferez tedavisinin etkisi tartışılmıştır.

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Cite This Article

BEŞİROĞLU, L., AĞARGÜN, M. Y., ÖZBEBİT, Ö., SÖZEN, M., DİLEK, İ., GÜLEÇ, M. (2007). Therapeutic response to plasmapheresis in four cases with obsessive-compulsive disorder and tic disorder triggered by streptococcal infections. Türk Psikiyatri Dergisi, Cilt: 18 - Sayı: 3, 270–276. https://ajindex.com/articles/90444

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