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Journals / Türk Psikiyatri Dergisi / 2008 / Cilt: 19 - Sayı: 1

Comparison of cerebral blood flow in children with obsessive compulsive disorder and attention deficit hyperactivity disorder

Obsesif kompulsif bozukluk ve dikkat eksikliği hiperaktivite bozukluğu olan çocukların serebral kan akımlarının karşılaştırılması

Pınar ÖNER
Özgür ÖNER
Ayla AYSEV
NURİYE ÖZLEM KÜÇÜK
ERKAN İBİŞ
Pages
13–18
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Studies which compare subjects with comorbid ADHD and OCD with pure forms of these disorders are necessary to have a better understanding of similarities and differences of these two disorders.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: It has been reported that both obsessive-compulsive disorder (OCD) and attention deficit hyperactivity disorder (ADHD) might be related to impairments in frontal-striatal brain circuits.
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Key Findings & Data:Method: Thirteen drug-naive OCD subjects (mean age ± SD: 10.4 ± 2.8), and 13 drug-naive ADHD subjects (mean age ± SD: 10.5 ± 2.2) were included in the study.
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Conclusion & Impact:Studies which compare subjects with comorbid ADHD and OCD with pure forms of these disorders are necessary to have a better understanding of similarities and differences of these two disorders.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Teknesyum Tc 99m ekzametazim · Hiperaktiviteyle beraber dikkat eksikliği bozukluğu · Serebral korteks

Abstract

Objective: It has been reported that both obsessive-compulsive disorder (OCD) and attention deficit hyperactivity disorder (ADHD) might be related to impairments in frontal-striatal brain circuits. Besides, these two disorders are frequently comorbid. However, there are no published studies directly comparing the neurobiological findings in these two disorders. The objective of the study was to investigate the differences in cortical blood flow between patients with OCD and ADHD. Method: Thirteen drug-naive OCD subjects (mean age ± SD: 10.4 ± 2.8), and 13 drug-naive ADHD subjects (mean age ± SD: 10.5 ± 2.2) were included in the study. Cerebral blood flow (CBF) was evaluated with Tc-99m-hexamethylpropyleneamine oxime (Tc99m HMPAO) brain single photon emission tomography (SPECT) during standard resting conditions in all cases. P value was set to <.006 after Bonferroni correction. Results: OCD cases had significantly higher right prefrontal (p=.003) CBF than ADHD cases. There were no significant CBF differences in other brain regions. OCD symptom severity was not related to CBF. Discussion: This is one of the very few studies which directly investigated brain imaging in pediatric OCD subjects. Results are consistent with previous studies reporting increased prefrontal CBF in OCD subjects. We also found that, consistent with the previous literature, ADHD subjects had lower prefrontal cortex CBF. Studies which compare subjects with comorbid ADHD and OCD with pure forms of these disorders are necessary to have a better understanding of similarities and differences of these two disorders.

Özet

Amaç: Hem obsesif kompulsif bozukluk (OKB) hem de dikkat eksikliği hiperaktivite bozukluğunun (DEHB) frontal-striatal beyin döngülerindeki değişiklikler ile ilişkili olduğu bildirilmiştir. Ayrıca bu bozukluklar sıklıkla da eşhastalanım göstermektedir. Buna karşın, bu iki bozukluktaki nörobiyolojik bulguları doğrudan karşılaştıran çalışma bulunmamaktadır. Bu çalışmanın amacı OKB ya da DEHB olan olgularla tek foton bilgisayarlı emisyon tomografisi (SPECT) ile kortikal kan akımının ölçümüdür. Yöntem: 13 ilaç kullanmamış OKB olgusu (ortalama yaş ± SD= 10.4 ± 2.8) ve 13 ilaç kullanmamış DEHB olgusu (yaş 10.5 ± 2.2) çalışmaya dahil edilmiştir. Beyin kan akımı (BKA) tüm olgularda istirahat koşullarında Tc-99m-hekzamethilpropileneamin oksim (Tc99m HMPAO) beyin SPECT ile ölçülmüştür. Bonferroni düzeltmesi ile anlamlılık p<.006 olarak saptanmıştır. Bulgular: OKB olgularının sağ prefrontal (p=.003) BKA değerleri DEHB olgularından anlamlı derecede yüksektir. Diğer beyin bölgelerindeki ölçümlerde farklılık saptanmamıştır. OKB belirtilerinin şiddeti ile BKA arasında ilişki bulunmamıştır. Tartışma: Çocuk ve ergen OKB olgularının doğrudan incelendiği çok az sayıdaki çalışmadan birisi olan bu çalışmada sonuçlar OKB olgularında prefrontal kortekste kan akımında artış olduğunu bildiren önceki çalışmalarla uyumludur. DEHB olgularında da, önceki literatürle uyumlu olarak, aynı bölgede kan akımında azalma saptanmıştır. Bu iki bozukluğun patofizyolojisi daha iyi anlaşılabilmesi için her iki bozukluğun bir arada ve tek başına olduğu durumların karşılaştırıldığı çalışmalar gereklidir.

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Cite This Article

ÖNER, P., ÖNER, Ö., AYSEV, A., KÜÇÜK, N. Ö., İBİŞ, E. (2008). Comparison of cerebral blood flow in children with obsessive compulsive disorder and attention deficit hyperactivity disorder. Türk Psikiyatri Dergisi, Cilt: 19 - Sayı: 1, 13–18. https://ajindex.com/articles/90262

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