Journals / Anatolian Current Medical Journal / 2023 / Cilt: 5 Sayı: 2

Advanced age; not a contraindiction for resections of colorectal liver metastasis recurrence

Pages
160–167
Publication Date
2023-03-27
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Repeat resections for the recurrence of CLMs in selected elderly patients are reliable with regards to similar survival outcomes achieved compared to their younger counterparts.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: The influence of advanced age on the outcome of repeat resections performed for colorectal liver metastasis (CLM) is ill-defined.
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Key Findings & Data:We aimed to evaluate the safety and efficacy of repeat resections performed for the recurrence of CLMs in younger (≤70 years) and elderly patients (70< years), and to define predictive factors of survival.
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Conclusion & Impact:Conclusion: Repeat resections for the recurrence of CLMs in selected elderly patients are reliable with regards to similar survival outcomes achieved compared to their younger counterparts.
🔬Design:Research Article
📍Scope:2019 Verileri
⚙️Variables:Colorectal liver metastasis (CLM) · liver recurrence · resection

Abstract

Aim: The influence of advanced age on the outcome of repeat resections performed for colorectal liver metastasis (CLM) is ill-defined. We aimed to evaluate the safety and efficacy of repeat resections performed for the recurrence of CLMs in younger (≤70 years) and elderly patients (70< years), and to define predictive factors of survival. Material and Method: A prospectively maintained database of a single center including 291 CLM patients between 1998 and 2019 was analyzed retrospectively. Short and long-term outcomes were compared among younger (n=99, 34%) and elderly (n=192, 66%) patient groups who were treated by repeat resections for CLM recurrence. Results: Although statistically not significant, analysis of different age groups (≤70, 70-75, 75-80, and 80< years) have given similar results in terms of 1, 3, and 5-year survival (p=0.143). Globally curative resection was validated as a determinant factor in the estimation of survival following resections performed for recurrences according to multivariate analysis (p<0.05). Conclusion: Repeat resections for the recurrence of CLMs in selected elderly patients are reliable with regards to similar survival outcomes achieved compared to their younger counterparts.

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Cite This Article

SÖNMEZ, R. E. (2023). Advanced age; not a contraindiction for resections of colorectal liver metastasis recurrence. Anatolian Current Medical Journal, Cilt: 5 Sayı: 2, 160–167. https://ajindex.com/articles/900837

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References (12)

  1. Chong G, Cunningham D. Improving long-term outcomes for patients with liver metastases from colorectal cancer. J Clin Oncol 2005; 23: 9063–6.
  2. Stangl R, Altendorf-Hofmann A, Charnley RM. Factors influencing the natural history of colorectal liver metastases. Lancet 1994; 343: 1405–10.
  3. Simmonds PC, Primrose JN, Colquitt JL, Garden OJ, Poston GJ, Rees M. Surgical resection of hepatic metastases from colorectal cancer: a systematic review of published studies. Br J Cancer 2006; 94: 982-99.
  4. Abdalla EK, Vauthey JN, Ellis LM, et al. Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined resection/ablation for colorectal liver metastases. Ann Surg 2004; 239: 818-27.
  5. Fong Y, Fortner J, Sun RL, Brennan MF, Blumgart LH. Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases. Ann Surg 1999; 230: 309-21.
  6. Zorzi D, Mullen JT, Abdalla EK, et al. Comparison between hepatic wedge resection and anatomic resection for colorectal liver metastases. J Gastrointest Surg 2006; 10: 86-94.
  7. Sa Cunha A, Laurent C, Rault A, Couderc P, Rullier E, Saric J. A second liver resection due to recurrent colorectal liver metastases. Arch Surg 2007; 142: 1144-50.
  8. Nishio H, Hamady ZZ, Malik HZ, et al. Outcome following repeat liver resection for colorectal liver metastases. Eur J Surg Oncol 2007; 33: 729–34. de Jong MC, Pulitano C, Ribero D, et al. Rates and patterns of recurrence following curative intent surgery for colorectal liver metastasis: an international multi-institutional analysis of 1669 patients. Ann Surg 2009; 250: 440–8.
  9. Brachet D, Lermite E, Rouquette A, Lorimier G, Hamy A, Arnaud JP. Prognostic factors of survival in repeat liver resection for recurrent colorectal metastases: review of sixty-two cases treated at a single institution. Dis Colon Rectum 2009; 52: 475–83.
  10. Brand MI, Saclarides TJ, Dobson HD, Millikan KW. Liver resection for colorectal cancer: liver metastases in the aged. Am Surg 2000; 66: 412-6
  11. Rubbia-Brandt L, Giostra E, Brezault C, et al. Importance of histological tumor response assessment in predicting the outcome in patients with colorectal liver metastases treated with neo-adjuvant chemotherapy followed by liver surgery. Ann Oncol 2007; 18: 299-304.
  12. Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 2004; 240: 205–13. Fernández-Tr