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Journals / Interdisciplinary Medical Journal / 2013 / Cilt: 4 - Sayı: 13

Evaluation of the efficacy of isotretinoin treatment on neutrophil/lymphocyte ratio and the other hemogram parameters

İSOTRETİNOİN TEDAVİSİNİN NÖTROFİL/LENFOSİT ORANI VE DİĞER HEMOGRAM PARAMETRELERİNE ETKİSİNİN DEĞERLENDİRİLMESİ

Pınar Özuğuz
Seval Kaçar
Serap Polat
Sena Ulu
Şemsettin Karaca
Pages
9–14
Publication Date
2015-03-03
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Besides the unchanged NLR values may support no inflammatory reactions occur during muticentered studies, evaluating these parameters with larger sample sizes are required. isotretinoin treatment.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: There are reports of various side effects of isotretinoin.
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Key Findings & Data:Material and methods: Sixty seven patients with moderate to severe acne vulgaris aged between 18 to 25, who were prescribed 0.5mg/kg isotretinoin, were included to the study.
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Conclusion & Impact:Besides the unchanged NLR values may support no inflammatory reactions occur during muticentered studies, evaluating these parameters with larger sample sizes are required. isotretinoin treatment.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Anahtar hemogram parametreleri · hemoglobin · monosit

Abstract

Aim: There are reports of various side effects of isotretinoin. Recent studies have controversial results about the necessity of laboratory investigation including hemogram and blood chemistry of patients during the follow up periodon isotretinoin.We aimed to investigate the effects of isotretinoin on Neutrophil/lymhocyte ratio (NLR) a systemic inflammation marker and the other hemogram parameters. Material and methods: Sixty seven patients with moderate to severe acne vulgaris aged between 18 to 25, who were prescribed 0.5mg/kg isotretinoin, were included to the study. Patients’ hemogram parameters before treatment and at the third month of treatment were recorded on SPSS 20.0 programme retrospectively. The difference between two values <0.05 was considered as statistically significant. Results: There were 37 female and 30 male patients, with a mean age of 21.12±3.54 years. There were no differences between the two groups by means of white blood count, neutrophil, lymphocyte counts and NLR. Among the other parameters, there was a statistically significant increase in monocyte count whereas basophil, eosinophil, platelet counts and hematocrit values revealed no differences. Red blood cells, hemoglobin, mean corpuscular volume and plateletocrit values revealed a statistically significant decrease (p<0.01). Conclusion: Isotretinoin, which is used as a miracle drug and favorable treatment of acne, may cause changes in hemogram parameters. It may lead to decreased hemoglobin values and increase of monocyte count during treatment. Patients with prominent iron deficiency may require close monitorization. Besides the unchanged NLR values may support no inflammatory reactions occur during muticentered studies, evaluating these parameters with larger sample sizes are required. isotretinoin treatment. Obviously

Özet

Amaç: Akne vulgariste sıklıkla kullanılanisotretinoin tedavisi sırasında pek çok farklı yanetki gelişebildiği bildirilmektedir. Son zamanlardayapılan çalışmalarda isotretinoin kullanan hastalarınkontrollerinde biyokimya ve hemogram gibilaboratuvar tetkiklerinin gerekliliği konusundatartışmalı görüşler bulunmaktadır. Bu çalışmadaisotretinoin tedavisi alan hastalarda sistemikinflamatuvar durumu göstermede kullanılannötrofil/lenfosit oranı ve diğer hemogramparametrelerindeki değişimi araştırmayı amaçladık.Gereç ve yöntemler: İsotretinoin tedavisi kullanan,18-25 yaş aralığında, orta ve şiddetli akne vulgarisiolan 67 hasta çalışmaya dahil edildi. Retrospektifolarak hastaların tedavi öncesi ve tedavinin 3.ayından sonraki hemogram parametreleri SPSS20.0 programına kaydedildi.Bulgular: Yaş ortalaması 21.12 ± 3.54 olanhastaların 37’si bayan, 30’u erkek idi. Hemogramparametrelerinden beyaz küre, nötrofil sayısı,lenfosit sayısı ve nötrofil / lenfosit oranında 2 değerarasında istatistiksel olarak farklılık saptanmadı.Diğer parametrelerden monosit düzeylerindeistatistiksel olarak anlamlı bir artış saptanırken,bazofil, eozinofil, platelet ve hemotokritdüzeylerinde fark görülmedi. Kırmızı hücreler,hemoglobin, kırmızı hücrelerin ortalama volumü veplateletokrit düzeyleri arasında istatistiksel olarakanlamlı azalma gözlendi.Sonuç: İsotretinoin tedavisi hemogramparametrelerinde değişikliklere yol açabilir. İlaçkullanım süresince özellikle hemoglobindüşüklüğüne, monosit artışına neden olabilir.Anemisiolan hastaları isotretinoin tedavisialtındayken yakın takip etmek gerekebilir.Buparametrelerin değerlendirildiği, çok sayıdahastanın yer aldığı çok merkezli çalışmalara ihtiyaçduyulmaktadır.

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Cite This Article

Özuğuz, P., Kaçar, S., Polat, S., Ulu, S., Karaca, Ş. (2015). Evaluation of the efficacy of isotretinoin treatment on neutrophil/lymphocyte ratio and the other hemogram parameters. Interdisciplinary Medical Journal, Cilt: 4 - Sayı: 13, 9–14. https://ajindex.com/articles/887804

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