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Journals / KONURALP TIP DERGİSİ / 2023 / Cilt: 15 - Sayı: 1

Apoptosis-associated speck-like protein containing a CARD (ASC), TNF Like Factor 1a(TL-1a) and B Cell Chemoattractant Chemokine Ligand 13(CXCL-13) expression profiles in familial Mediterranean fever (FMF) patients

Ailesel Akdeniz Ateşi (AAA) Hastalarında Apoptosis-associated speck-like protein containing a CARD (ASC), TNF Like Factor 1a(TL-1a) ve B Cell Chemoattractant Chemokine Ligand 13(CXCL 13) Genlerinin Ekpresyon Düzeylerinin İncelenmesi

Fatih KURT
Recep ERÖZ
Kenan KOCABAY
Pages
59–68
Publication Date
2023-03-15
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: The expression levels of these genes may be related to the pathogenesis of the disease and these genes could be used as a marker in the early diagnosis of the disease.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: This study was carried out to compare the expression levels of ASC(Apoptosis Associated Speck Like Protein Containing a CARD), TL-1a(TNF Like Factor 1a) and CXCL 13(B Cell Chemoattractant Chemokine Ligand 13) genes in FMF patients According to Tell-Hashomer Criteria and Genetic analysis result in Düzce University Research and Application Hospital with healthy controls and to determine their clinical significance in FMF.
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Key Findings & Data:Method: 36 patients (20 girls, 16 boys) and 12 healthy controls (7 girls, 5 boys) were included in the study.
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Conclusion & Impact:Conclusion: The expression levels of these genes may be related to the pathogenesis of the disease and these genes could be used as a marker in the early diagnosis of the disease.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:AAA · ASC · CXCL 13

Abstract

Objectives: This study was carried out to compare the expression levels of ASC(Apoptosis Associated Speck Like Protein Containing a CARD), TL-1a(TNF Like Factor 1a) and CXCL 13(B Cell Chemoattractant Chemokine Ligand 13) genes in FMF patients According to Tell-Hashomer Criteria and Genetic analysis result in Düzce University Research and Application Hospital with healthy controls and to determine their clinical significance in FMF. Method: 36 patients (20 girls, 16 boys) and 12 healthy controls (7 girls, 5 boys) were included in the study. RNA was isolated from the peripheral blood of each individual and expression levels of ASC, TL-1a and CXCL 13 genes were determined. Routine biochemical parameters were also determined. Result: CXCL 13 and TL-1a gene expression levels were significantly increased in patients with FMF, the expression level of the ASC gene was found to be increased in FMF patients, but not significantly. Conclusion: The expression levels of these genes may be related to the pathogenesis of the disease and these genes could be used as a marker in the early diagnosis of the disease.

Özet

Amaç: Bu çalışma genetik analizi Düzce Üniversitesi Araştırma ve Uygulama Hastanesi'nde yapılan ve Tell-Hashomer Kriterleri’ne göre Ailesel Akdeniz Ateşi tanısı konan hastalarda ASC (Apoptosis Associated Speck Like Protein Containing a CARD), TL-1a(TNF Like Factor 1a) ve CXCL 13(B Cell Chemoatractant Chemokine Ligand 13) genlerinin ekspresyon düzeylerini sağlıklı kontroller ile karşılaştırmak ve AAA'daki klinik önemini belirlemek amacıyla yapılmıştır. Metod: Çalışmaya 36 hasta (20 kız, 16 erkek) ve 12 sağlıklı kontrol (7 kız, 5 erkek) dahil edildi. Her bireyin periferik kanından RNA izole edildi ve ASC, TL-1a ve CXCL 13 genlerinin ekspresyon seviyeleri belirlendi. Rutin biyokimyasal parametreler de belirlendi. Bulgular: AAA hastalarında CXCL 13 ve TL-1a gen ekspresyon seviyeleri anlamlı olarak artarken, ASC geninin ekspresyon seviyesinin arttığı ancak anlamlı olmadığı bulundu. Sonuç: Bu genlerin ekspresyon düzeyleri hastalığın patogenezi ile ilişkili olabilir ve bu genler hastalığın erken tanısında bir belirteç olarak kullanılabilir.

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Cite This Article

KURT, F., ERÖZ, R., KOCABAY, K. (2023). Apoptosis-associated speck-like protein containing a CARD (ASC), TNF Like Factor 1a(TL-1a) and B Cell Chemoattractant Chemokine Ligand 13(CXCL-13) expression profiles in familial Mediterranean fever (FMF) patients. KONURALP TIP DERGİSİ, Cilt: 15 - Sayı: 1, 59–68. https://ajindex.com/articles/886981

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