Journals / Türk Psikiyatri Dergisi / 2013 / Cilt: 24 - Sayı: 4

Cognitive Functions in Patients with Obsessive Compulsive Disorder

Obsesif Kompulsif Bozuklukta Bilişsel İşlevler

Pages
266–274
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Longitudinal family studies that employ both neuropsychological testing and brain imaging are needed to more clearly elucidate the relationship between cognitive dysfunction and OCD.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: This literature review aimed to examine the relationship between cognitive impairment and obsessive-compulsive disorder (OCD).
📊
Key Findings & Data:Studies based on neuropsychological testing were prioritized, but those dealing with clinical features, therapy, comorbidity, neuroimaging, and the families of OCD patients were also considered.
💡
Conclusion & Impact:Longitudinal family studies that employ both neuropsychological testing and brain imaging are needed to more clearly elucidate the relationship between cognitive dysfunction and OCD.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: This literature review aimed to examine the relationship between cognitive impairment and obsessive-compulsive disorder (OCD). Studies based on neuropsychological testing were prioritized, but those dealing with clinical features, therapy, comorbidity, neuroimaging, and the families of OCD patients were also considered. Materials and Methods: The literature on cognitive impairment in OCD was reviewed and then the studies evaluating the relationship with these above mentioned findings were discussed. Results: The clinically most important cognitive impairment in OCD is executive dysfunction, followed by impaired memory. Cognitive impairment has also been observed in the healthy relatives of OCD patients. Findings regarding the effects of comorbidity on cognitive function in OCD patients are inconsistent. Brain imaging studies suggest that frontostriatothalamic dysfunction might occur in OCD. Conclusion: Executive dysfunction in OCD patients is well documented; however, the precise nature of the relationship between the severity of cognitive dysfunction and the clinical features of OCD are not well understood. Longitudinal family studies that employ both neuropsychological testing and brain imaging are needed to more clearly elucidate the relationship between cognitive dysfunction and OCD.

Özet

Amaç: Bu yazıda obsesif kompulsif bozukluk (OKB) ve bilişsel işlevlerle ilgili yazın gözden geçirilmiştir. Bilişsel işlevlerin nöropsikolojik testlerle değerlendirildiği çalışmalara öncelik verilmiştir. Klinik özellikler, tedavi, ek tanı, beyin görüntüleme ve aile çalışmalarından kısaca söz edilmiştir. Yöntem: OKB’de bilişsel işlev bozukluklarını inceleyen çalışmalar göz- den geçirilmiştir. Daha sonra bu bulguların yukarıda sözü edilen etmen- lerle olan ilişkisini inceleyen çalışmalar ele alınmıştır. Bulgular: OKB’de birincil bilişsel bozukluk, yürütücü işlev bozukluğu gibi görünmektedir. Bellekle ilgili bozukluklar, yürütücü işlev bozuk- luklarına ikincildir. OKB tanısı olan hastaların sağlıklı akrabalarında da bilişsel bozukluklar saptanmıştır. Ek tanının bilişsel işlevler üzerine olan etkileri ile ilgili bulgular çelişkilidir. Beyin görüntüleme çalışmalarının bir kısmı, OKB’de frontostriatotalamik yolaklardaki işlev bozukluğunu destekler niteliktedir. Sonuç: OKB’de yürütücü işlev bozukluğunun varlığı pek çok çalışma- da gösterilmiştir. Bilişsel bozuklukların nörobiyolojisi ve klinik özellik- lerle ilişkisi hakkında bilinenler henüz kısıtlıdır. Bu alanda yapılan be- yin görüntüleme çalışmaları sınırlıdır. Nöropsikoloji ve beyin görüntü- leme tekniklerinin birlikte kullanılacağı uzunlamasına yapılacak akraba çalışmalarına gereksinim duyulmaktadır.

🔖

Cite This Article

ÇETİNAY, P. A., GÜLEÇ, D. Ö. (2013). Cognitive Functions in Patients with Obsessive Compulsive Disorder. Türk Psikiyatri Dergisi, Cilt: 24 - Sayı: 4, 266–274. https://ajindex.com/articles/88665

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. Abbruzzese M, Ferri S, Scarone S (1995) Wisconsin Card Sorting Test performance in obsessive-compulsive disorder: no evidence for involvement of dorsolateral prefrontal cortex. Psychiatry Res 58:37-43.
  2. Abbruzzese M, Ferri S, Scarone S (1997) The selective breakdown of frontal functions in patients with obsessive-compulsive disorder and in patients with schizophrenia: a double dissociation experimental finding. Neuropsychologia 35:907-12.
  3. Aycicegi A, Dinn WM, Harris CL ve ark. (2003) Neuropsychological function in obsessive-compulsive disorder: effects of comorbid conditions on task performance. Eur Psychiatry 18:241-8.
  4. Basso MR, Bornstein RA, Carona F ve ark. (2001) Depression accounts for executive function deficits in obsessive-compulsive disorder. Neuropsy Neuropsy Be 14:241-5. Bédard MJ, Joyal CC, Godbout L ve ark. (2009) Executive functions and the obsessive-compulsive disorder: on the importance of subclinical symptoms and other concomitant factors. Arch Clin Neuropsychol 24:585-98.
  5. Bohne A, Savage CR, Deckersbach T ve ark. (2005) Visuospatial abilities, memory, and executive functioning in trichotillomania and obsessive- compulsive disorder. J Clin Exp Neuropsychol 27:385-99.
  6. Brennan BP, Rauch SL, Jensen JE ve ark. (2013) A critical review of magnetic resonance spectroscopy studies of obsessive-compulsive disorder. Biol Psychiatry 73:24-31.
  7. Cavedini P, Bassi T, Zorzi C ve ark. (2004) The advantages of choosing antiobsessive therapy according to decision-making functioning. J Clin Psychopharmacol 24:628-31.
  8. Cavedini P, Riboldi G, D’Annucci A ve ark. (2002) Decision-making heterogeneity in obsessive-compulsive disorder: ventromedial prefrontal cortex function predicts different treatment outcomes. Neuropsychologia 40:205-11.
  9. Ceschi G, Van der Linden M, Dunker D ve ark. (2003) Further exploration memory bias in compulsive washers. Behav Res Ther 41:737-48.
  10. Chamberlain SR, Blackwell AD, Fineberg NA ve ark. (2005)The neuropsychology of obsessive compulsive disorder: the importance of failures in cognitive and behavioural inhibition as candidate endophenotypic markers. Neurosci Biobehav Rev 29:399-419.
  11. Chamberlain SR, Fineberg NA, Blackwell AD ve ark. (2006) Motor inhibition and cognitive flexibility in obsessive-compulsive disorder and trichotillomania. Am J Psychiatry 163:1282-4.
  12. Chamberlain SR, Fineberg NA, Menzies LA ve ark. (2007) Impaired cognitive flexibility and motor inhibition in unaffected first-degree relatives of patients with obsessive-compu