Journals / Acta Medica Nicomedia / 2023 / Cilt: 6 - Sayı: 1

INFLAMMATION IN NEWLY DIAGNOSED DIABETES PATIENTS

YENİ TANI DİYABET HASTALARINDA İNFLAMASYON

Pages
143–147
Publication Date
2023-02-28
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Therefore, these parameters may guide the diagnosis and preventive treatment in prediabetic patients.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Type 2 diabetes mellitus (T2DM) is a chronic disease with an increasing prevalence, accounting for 90-95% of all diabetics.
📊
Key Findings & Data:In this study, we aimed to investigate the inflammation parameters and the relationship of these parameters with blood groups in newly diagnosed T2DM patients.
💡
Conclusion & Impact:Therefore, these parameters may guide the diagnosis and preventive treatment in prediabetic patients.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Tip 2 diyabetes mellutus · inflamasyon · kan grubu

Abstract

Objective. Type 2 diabetes mellitus (T2DM) is a chronic disease with an increasing prevalence, accounting for 90-95% of all diabetics. It is considered that the disease is induced by inflammation. In this study, we aimed to investigate the inflammation parameters and the relationship of these parameters with blood groups in newly diagnosed T2DM patients. Methods. The study included 80 newly diagnosed T2DM patients and 80 healthy volunteers. Demographic characteristics, body mass indexes (BMI), biochemistry and hemogram test results, C-reactive protein (CRP) values, and blood groups of the patient and control groups were recorded and compared between the groups. Results. The mean age was 51.64 years and 53.8% of the patients were male in the newly diagnosed T2DM group. The counts of white blood cells (WBC), neutrophils, lymphocytes, platelets, and monocytes, the values of the monocyte/HDL ratio (MHR) and the systemic immune-inflammatory index (SII), and the CRP levels of T2DM patients were statistically significantly higher than those of the control group (p<0.05). Of the T2DM patients, the platelet counts were statistically significantly higher in the blood type B group compared to the blood type O group (p=0.022). Conclusion. We think that the hematological parameters of inflammation and the high MHR and SII ratios indicate the presence of chronic systemic inflammation in newly diagnosed T2DM patients before the development of complications. Therefore, these parameters may guide the diagnosis and preventive treatment in prediabetic patients.

Özet

Amaç: Tip 2 diyabetes mellutus (T2DM), inflamasyonun indüklediği düşünülen, tüm diyabetlilerin %90-95’ini oluşturan prevelansı giderek artan kronik bir hastalıktır. Bu çalışmada yeni tanı almış T2DM olan hastalarda inflamasyon parametrelerini ve bu parametrelerin kan grupları ile ilişkisini araştırmayı amaçladık. Yöntem: Bu çalışmaya 80 yeni tanı almış T2DM hastası, 80 sağlıklı gönüllü dahil edildi. Hasta ve kontrol grubunun demografik özellikleri, vücut kitle indeksleri (VKİ), biyokimya, hemogram, C-reaktif proteini (CRP) ve kan grupları kayıt edilerek gruplar arasında karşılaştırıldı. Bulgular: Yeni tanı alan T2DM hastalarının yaş ortalaması 51,64’dü ve hastaların %53,8’i erkekti. T2DM hastaların beyaz kan hücresi (BKH), nötrofil, lenfosit, platelet, monosit, monosit/HDL oranı (MHO), sistemik immün-inflamatuar indeks (Sİİ) ve CRP düzeyleri kontrol grubundan istatistiksel olarak anlamlı derecede yüksek saptandı. (p<0,05) T2DM’li hastalarda kan grubu B olanların platelet değerleri, kan grubu O olan grupdan istatistiksel olarak anlamlı derecede yüksek saptandı. (p=0,022) Sonuç: Yeni tanı T2DM hastalarında inflmasyonu gösteren hematolojik parametrelerin ve MHO ve Sİİ oranlarındaki yüksekliğinin, hastalarda komplikasyon gelişmeden kronik sistemik enflamasyonun varlığını gösterdiğini, prediyabetik hastalarda tanıda ve koruyucu tedaviye başlamada yol gösterici olabileceğini düşünüyoruz.

🔖

Cite This Article

SARIÇAM, O. (2023). INFLAMMATION IN NEWLY DIAGNOSED DIABETES PATIENTS. Acta Medica Nicomedia, Cilt: 6 - Sayı: 1, 143–147. https://ajindex.com/articles/884656

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. American Diabetes A 2. Classification and diagnosis of diabetes: standards of medical care in diabetes-2019. Diabetes Care. 2019
  2. 13–28. doi.org/10.2337/ dc19-S002 2. Oever IAM, Raterman HG, Nurmohamed MT, Simsek S. Endothelial Dysfunction, Inflammation, and Apoptosis in Diabetes Mellitus. Mediators Inflamm. 2010
  3. 792393. doi:10.1155/2010/792393 3. Biondi-Zoccai GG, Abbate A, Liuzzo G, Biasucci LM. Atherothrombosis, inflammation, and diabetes. J Am Coll Cardiol. 2003
  4. 1071–1077. doi:10.1016/s0735-109 7(03)00088-3 4. Böni-Schnetzler M, Thorne J, Parnaud G, et al. Increased interleukin (IL)-1β messenger ribonucleic acid expression in β-cells of individuals with type 2 diabetes and regulation of IL-1β in human islets by glucose and autostimulation, J Clin Endocrinol Metab. 2008
  5. 93 (10):4065–4074. doi:10.1210/jc.2008-0396 5. Bays H, Mandarino L, DeFronzo RA. Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach. Journal of Clinical Endocrinology and Metabolism, vol. 2004
  6. 89(2):463–478. doi:10.1210/jc. 2003-030723 6. Crook M. Type 2 diabetes mellitus: a disease of the innate immune system? An update. Diabet Med. 2004
  7. 21(3):203–207. doi:10.1046/j.1464-5491.2003.010 30.x 7. Duman TT, Aktas G, Atak BM, Kocak MZ, Erkus E, Savli H. Neutrophil to lymphocyte ratio as an indicative of diabetic control level in type 2 diabetes mellitus. Afr Health Sci. 2019
  8. 1602–1606. doi:10.4314/ahs.v19i1.35 8. Jaaban M, Zetoune AB, Hesenow S, Hessenow R. Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio as novel risk markers for diabetic nephropathy in patients with type 2 diabetes. Heliyon. 2021
  9. 7(7): e07564. doi:10.1016/j.heliyon.2021.e07564 9. Ewald DR, Sumner SC. Blood type biochemistry and human disease. Wiley Interdiscip Rev Syst Biol Med. 2016
  10. 517–35. doi:10.1002/wsbm.1355 10. Liumbruno GM, Franchini M. Beyond immune haematology: The role of the ABO blood group in human diseases. Blood Transfus. 2013
  11. 491–9. doi:10.2450/ 2013.0152-13 11. Bahar A, Asadian L, Abediankenai S, Namazi SS, Kashi Z. Coronary heart disease and ABO blood group in diabetic women: a case-control study. Scientific Reports. 2019
  12. 9(1):1–6. doi:10.1038/s41598-019-43890-4 12. Jankowski JA. Inflammation and Gastrointestinal Cancers: Springer Science & Business Media, Springer, Berlin, Heidelberg, 2011. 13. Feng JF, Chen S, Yang X. Systemic immune