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Journals / Veterinary Journal of Kastamonu University / 2022 / Cilt: 1 - Sayı: 2

The effect of pentoxifylline administration at different doses on hematological and biochemical parameters in sheep

Duygu DURNA ÇORUM
Orhan ÇORUM
Ayşe ER
Kamil ÜNEY
Pages
10–16
Publication Date
2022-12-31
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Hematological parameters did not alter between the groups, although it was found that the hematocrit value in 20 mg/ kg dosage group dropped.

📌 3 Key Takeaways

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Objective & Hypothesis:The aim of the present study was to determine the effect of administration of single increasing doses of pentoxifylline on biochemical and hematological parameters in sheep.
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Key Findings & Data:Pentoxifylline was given to sheep intravenously at doses of 10, 20, and 40 mg/ kg.
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Conclusion & Impact:Hematological parameters did not alter between the groups, although it was found that the hematocrit value in 20 mg/ kg dosage group dropped.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Biochemical · hematological · sheep

Abstract

The aim of the present study was to determine the effect of administration of single increasing doses of pentoxifylline on biochemical and hematological parameters in sheep. The study was carried out on six healthy Merino sheep. Pentoxifylline was given to sheep intravenously at doses of 10, 20, and 40 mg/ kg. Blood samples were taken from the jugular vein before (0 hour) and after (12 hour) pentoxifylline administration. Biochemical parameters such as creatine kinase, albumin, blood urea nitrogen, creatinine, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, gamma glutamyltransferase, cholesterol, triglyceride, total bilirubin and total protein were measured in autoanalyzer. Hematological parameters such as hemoglobin, hematocrit, platelet, red blood cells and white blood cells were determined in blood cell counter. Hematological parameters did not alter between the groups, although it was found that the hematocrit value in 20 mg/ kg dosage group dropped. There were no significant changes in biochemical values following administration of the pentoxifylline at all dose level. These results show that pentoxifylline does not cause significant changes in biochemical and hematological parameters in sheep after intravenous administration at different doses. However, the safety study on pentoxifylline is also also necessary for multiple ascending doses in sheep.

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Cite This Article

ÇORUM, D. D., ÇORUM, O., ER, A., ÜNEY, K. (2022). The effect of pentoxifylline administration at different doses on hematological and biochemical parameters in sheep. Veterinary Journal of Kastamonu University, Cilt: 1 - Sayı: 2, 10–16. https://ajindex.com/articles/873989

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References (10)

  1. Antunes, S.A., Teixeira, M.C.B., & Júnior, A.G. (2008). Pentoxifylline effects on the resistant anemia to erythropoietin in hemodialysis patients. Revista Brasileira de Hematologia e Hemoterapia, 30(4), 303-308.
  2. Chalmeh, A., Rahmani Shahraki, A., Heidari, S.M., Badiei, K., Paurjafar, M., Nazifi, S., & Zamiri, M.J. (2016). The comparative efficacy of tyloxapol versus pentoxifylline against induced acute phase response in an ovine experimental endotoxemia model. Inflammopharmacology, 24, 59-64. Cioboată, R., Găman, A., Traşcă, D., Ungureanu, A., Docea, A.O., Tomescu, P., Gherghina, F., Arsene, A.L., Badiu, C., Tsatsakis, A.M., Spandidos, D.A., Drakoulis, N., & Călina, D. (2017). Pharmacological management of non-alcoholic fatty liver disease: Atorvastatin versus pentoxifylline. Experimental and Therapeutic Medicine, 13, 2375-2381.
  3. Cooper, A., Mikhail, A., Lethbridge, M.W., Kemeny, D.M., & Macdougall, I.C. (2004). Pentoxifylline improves hemoglobin levels in patients with erythropoietin-resistant anemia in renal failure. Journal of the American Society of Nephrology, 15, 1877-1882.
  4. Corum, O., Corum, D.D., Atik, O., Er, A., & Uney, K. (2019). Pharmacokinetics of pentoxifylline and its 5- hydroxyhexyl metabolite after intravenous administration of increasing doses to sheep. American Journal of Veterinary Research, 80(7), 702-708.
  5. Corum, O., Dik, B., Bahcivan, E., Eser, H., Er, A., & Yazar, E. (2016). Cardiac safety of gamithromycin in ewes. Eurasian Journal of Veterinary Sciences, 32, 242-245.
  6. Corum, O., Er, A., Dik, B., Eser, H., Bahcivan, E., & Yazar, E. (2015). Determination of the safety of tulathromycin in sheep. Eurasian Journal of Veterinary Sciences, 31(3), 152-157.
  7. Corum, O., Ozdemir, O., Hitit, M., Corum, D.D., Coskun, D., & Er, A. (2018). Pentoxifylline may restore kanamycin-induced renal damage in rats. Acta Scientiae Veterinariae, 46(1), 1-7.
  8. Corum, O., Uney, K., Er, A., & Durna Corum, D., (2022). The effect of cefquinome on hematological and biochemical parameters following repeated subcutaneous administrations in sheep. Veterinary Journal of Kastamonu University, 1(1), 1-7.
  9. Coskun, D., Cetin, G., & Corum, O. (2022). Effect of ascending doses of pentoxifylline administration on biochemical and hematological parameters in goats. Kocatepe Veterinary Journal, 15(1), 63-68.
  10. De Boever, S., Baert, K., De Backer, P., & Croubels, S. (2005). Pharmacokinetics and oral bioavailability of pentoxyfylline in broiler chickens. Journal of Veterinary Pharmac