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Journals / Ankara Üniversitesi Eczacılık Fakültesi Dergisi / 2020 / Cilt: 44 - Sayı: 3

DEVELOPMENT AND CHARACTERIZATION OF MUCOADHESIVE-THERMOSENSITIVE BUCCAL GEL CONTAINING METRONIDAZOLE FOR THE TREATMENT OF ORAL MUCOSITIS

ORAL MUKOZİT TEDAVİSİ İÇİN METRONİDAZOL İÇEREN MUKOADEZİF-TERMOSENSİTİF BUCCAL JELİN GELİŞTİRİLMESİ VE KARAKTERİZASYONU

Melike ONGUN
Emre TUNÇEL
Esra KODAN
Fatma Nur TUĞCU DEMİRÖZ
Fahriye Figen TIRNAKSIZ
Pages
517–539
Publication Date
2020-09-30
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Objective: This study was aimed to develop and characterize, mucoadhesive-thermosensitive gel formulation containing metronidazole that can quickly gel at the buccal mucosa temperature for treatment of oral mucositis.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: This study was aimed to develop and characterize, mucoadhesive-thermosensitive gel formulation containing metronidazole that can quickly gel at the buccal mucosa temperature for treatment of oral mucositis.
📊
Key Findings & Data:Objective: This study was aimed to develop and characterize, mucoadhesive-thermosensitive gel formulation containing metronidazole that can quickly gel at the buccal mucosa temperature for treatment of oral mucositis.
💡
Conclusion & Impact:Objective: This study was aimed to develop and characterize, mucoadhesive-thermosensitive gel formulation containing metronidazole that can quickly gel at the buccal mucosa temperature for treatment of oral mucositis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Metronidazole · mucoadhesive-thermosensitive gel · oral mucositis

Abstract

Objective: This study was aimed to develop and characterize, mucoadhesive-thermosensitive gel formulation containing metronidazole that can quickly gel at the buccal mucosa temperature for treatment of oral mucositis.

Özet

Amaç: Bu çalışmada oral mukozit tedavisi için bukkal mukoza sıcaklığında hızla jelleşebilen, metronidazol içeren mukoadhesif-termosensitif jel formülasyonu hazırlanması ve karakterize edilmesi amaçlanmıştır.

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Cite This Article

ONGUN, M., TUNÇEL, E., KODAN, E., DEMİRÖZ, F. N. T., TIRNAKSIZ, F. F. (2020). DEVELOPMENT AND CHARACTERIZATION OF MUCOADHESIVE-THERMOSENSITIVE BUCCAL GEL CONTAINING METRONIDAZOLE FOR THE TREATMENT OF ORAL MUCOSITIS. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, Cilt: 44 - Sayı: 3, 517–539. https://ajindex.com/articles/83262

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References (12)

  1. Lalla, R. V., Peterson, D. E. (2005). Oral mucositis. Dental Clinics of North America, 49 (1 SPEC.ISS.), 167–184
  2. Trotti, A., Bellm, L.A., Epstein, J. B., Frame, D., Fuchs, H. J., Gwede, C. K., Komaroff, E., Nalysnyk, L., Zilberberg, M.D. (2003). Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: A systematic literature review. Radiotherapy and Oncology, 66 (3), 253-62
  3. Itoh, Y., Kubota, S., Kawamura, M., Nomoto, Y., Murao, T., Yamakawa, K., Ishihara, S., Hirasawa, N., Asano, A., Yanagawa, S., Naganawa, S. (2016). A multicenter survey of stage T1 glottic cancer treated with radiotherapy delivered in 2.25-Gy fractions in clinical practice: An initial 5-year analysis. Nagoya Journal of Medical Science, 78 (4), 399–406
  4. Donnelly, J. P., Bellm, L. A., Epstein, J. B., Sonis, S. T., Symonds, R. P. (2003). Antimicrobial therapy to prevent or treat oral mucositis. Lancet Infectious Diseases, 3 (7), 405–412
  5. Mosel, D. D., Bauer, R. L., Lynch, D. P., Hwang, S. T. (2011). Oral complications in the treatment of cancer patients. Oral Diseases, 17 (6), 550–559
  6. Villa, A., Sonis, S. T. (2015). Mucositis: Pathobiology and management. Current Opinion in Oncology, 27 (3), 159–164
  7. Chan, A., Ignoffo, R.J. (2005). Survey of topical oral solutions for the treatment of chemo-induced oral mucositis. Journal of Oncology Pharmacy Practice, 11 (4), 139–143
  8. Buchsel, P. C. (2008). Polyvinylpyrrolidone-sodium hyaluronate gel (Gelclair®): A bioadherent oral gel for the treatment of oral mucositis and other painful oral lesions. Expert Opinion on Drug Metabolism and Toxicology, 4 (11), 1449–1454
  9. Carl, W., Emrich, L. S. (1991). Management of oral mucositis during local radiation and systemic chemotherapy: A study of 98 patients. The Journal of Prosthetic Dentistry, 66 (3), 361–369
  10. Leiknes, T., Leknes, K. N., Böe, O. E., Skavland, R. J., Lie, T. (2007). Topical use of a metronidazole gel in the treatment of sites with symptoms of recurring chronic inflammation. Journal of Periodontology, 78 (8), 1538–1544
  11. Jones, D. S., Woolfson, A. D., Brown, A. F., Coulter, W. A., McClelland, C., Irwin, C. R. (2000). Design, characterisation and preliminary clinical evaluation of a novel mucoadhesive topical formulation containing tetracycline for the treatment of periodontal disease. Journal of Controlled Release, 67 (2–3), 357–368
  12. Kaur, J., Kaur, J., Jaiswal, S., Gup