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Journals / Ankara Üniversitesi Eczacılık Fakültesi Dergisi / 2020 / Cilt: 44 - Sayı: 3

THE INVESTIGATION OF ANTIPROLIFERATIVE EFFECTS OF QUERCETIN, CURCUMIN AND THEIR COMBINATIONS ON BREAST CANCER CELL LINES

KUERSETİN, KURKUMİN VE KOMBİNASYONLARININ MEME KANSERİ HÜCRE HATLARI ÜZERİNDEKİ ANTİPROLİFERATİF ETKİLERİNİN ARAŞTIRILMASI

Ergul MUTLU ALTUNDAG
Eda BECER
Duygu GENCALP
Seda VATANSEVER
Pages
424–436
Publication Date
2020-09-30
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The aim of this study was to determine the antiproliferative effect of quercetin and curcumin which are flavonoids known to have anticancer properties on human metastatic and non metastatic breast cancer cell lines of alone and in combination usage.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Breast cancer is a type of cancer that has high malignancy and mortality rates in women and is frequently seen in the Eastern Mediterranean region.
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Key Findings & Data:Flavonoids such as quercetin and curcumin are known to have an ability to inhibit the growth of cancer cells.
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Conclusion & Impact:The aim of this study was to determine the antiproliferative effect of quercetin and curcumin which are flavonoids known to have anticancer properties on human metastatic and non metastatic breast cancer cell lines of alone and in combination usage.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Antiproliferative effect · quercetin · curcumin

Abstract

Objective: Breast cancer is a type of cancer that has high malignancy and mortality rates in women and is frequently seen in the Eastern Mediterranean region. Flavonoids such as quercetin and curcumin are known to have an ability to inhibit the growth of cancer cells. The aim of this study was to determine the antiproliferative effect of quercetin and curcumin which are flavonoids known to have anticancer properties on human metastatic and non metastatic breast cancer cell lines of alone and in combination usage.

Özet

Amaç: Meme kanseri, kadınlarda malignite ve mortalite oranı yüksek olan ve Doğu Akdeniz bölgesinde sıklıkla görülen bir kanser türüdür. Kuersetin ve kurkumin, kanser hücrelerinin büyümesini inhibe etme özelliği olduğu bilinen flavonoid türleridir. Bu çalışmanın amacı, antikanser özelliğe sahip olduğu bilinen kuersetin ve kurkumin flavonoidlerinin tek başına ve kombine kullanımının metastatik ve metastatik olmayan meme kanser hücre hatlarındaki antiproliferatif etkisinin belirlenmesidir.

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Cite This Article

ALTUNDAG, E. M., BECER, E., GENCALP, D., VATANSEVER, S. (2020). THE INVESTIGATION OF ANTIPROLIFERATIVE EFFECTS OF QUERCETIN, CURCUMIN AND THEIR COMBINATIONS ON BREAST CANCER CELL LINES. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, Cilt: 44 - Sayı: 3, 424–436. https://ajindex.com/articles/83255

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References (15)

  1. Akkuzu, M.Z., Küçüköner, M., Irtegun, S et al. (2019). Meme Kanserinde Brca-1 ve Brca-2’ de Sık Görülen Polimorfizm Mutasyonların Bölgemizde Varlığı. Dicle Med J, 46, 623–631
  2. Elbachiri, M., Fatima, S., Bouchbika, Z et al. (2017). Breast cancer in men: About 40 cases and literature review. Pan Afr. Med. J, 28, 287
  3. Foley, N.M., Coll, J.M., Lowery, A.J et al. (2018). Re-Appraisal of Estrogen Receptor Negative/Progesterone Receptor Positive (ER−/PR+) Breast Cancer Phenotype: True Subtype or Technical Artefact? Pathol. Oncol. Res, 24, 881–884
  4. Anderson, W.F, Chatterjee. N., Ershler, W.B, Brawley, O.W. (2002). Estrogen receptor breast cancer phenotypes in the Surveillance, Epidemiology, and End Results database. Breast Cancer Res. Treat, 76, 27–36
  5. Nadji, M., Gomez-Fernandez, C., Ganjei-Azar, P., Morales, A.R. (2005). Immunohistochemistry of Estrogen and Progesterone Receptors Reconsidered. Am. J. Clin. Pathol, 123, 21–27
  6. Erić, I., Erić, A.P., Kristek, J., Koprivčić, I., Babić, M. (2018). Breast cancer in young women: Pathologic and immunohistochemical features. Acta Clin. Croat, 57, 497–502
  7. Kampa, M., Nifli, A.P., Notas, G., Castanas, E. (2007). Polyphenols and cancer cell growth. Rev. Physiol. Biochem. Pharmacol, 159, 79–113
  8. Birman, H. (2012). Bitkisel Flavonoid Bileşiklerinin Biyoaktiviteleri ve Muhtemel Etki Mekanizmaları. İstanbul Tıp Fakültesi Derg, 75, 46–49
  9. Slimestad, R., Fossen, T., Vågen, I.M. (2007). Onions: A source of unique dietary flavonoids. J Agr Food Chem, 55, 10067–10080
  10. Spagnuolo, C., Russo, M., Bilotto, S., Tedesco, I., Laratta, B., Russo, G.L. (2012). Dietary polyphenols in cancer prevention: the example of the flavonoid quercetin in leukemia. Ann. N. Y. Acad. Sci, 1259, 95–103
  11. Nam, J.S., Sharma, A.R., Nguyen, L.T., Chakraborty, C., Sharma, G., Lee, S. (2016). Application of bioactive quercetin in oncotherapy: From nutrition to nanomedicine. Molecules, 21(1), E108
  12. Mutlu Altundağ, E., Yılmaz, A.M., Kocturk, S., Taga, Y., Yalçın, A.S. (2017). Synergistic Induction of Apoptosis by Quercetin and Curcumin in Chronic Myeloid Leukemia (K562) Cells. Nutr Cancer, 70, 97-108
  13. Nagahama, K., Utsimi, T., Kumano, T., Maekawa, S., Oyama, N., Kawakami, J. (2016). Discovery of a new function of curcumin which enhances its anticancer therapeutic potency. Sci. Rep, 6, 30962
  14. Troselj, K., Kujundzic, R. (2014). Curcumin in Combined Cancer Therapy. Curr. Pharm. Des, 20, 6682–6696
  15. Kunnumakkara, A.B., B