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Journals / Ankara Üniversitesi Eczacılık Fakültesi Dergisi / 2021 / Cilt: 45 - Sayı: 1

THE ROLE OF GLUTATION-S-TRANSFERASE MU1 AND TETA1 POLYMORPHISMS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE

KRONİK OBSTRÜKTİF AKCİĞER HASTALIĞINDA GLUTATYON-S-TRANSFERAZ MU1 VE TETA1 POLİMORFİZMLERİNİN ROLÜ

Buket HAYAT
Muhsin Selçuk YAVUZ
Mustafa Engin ŞAHİN
Onur DİRİCAN
Sezen YILMAZ
Can YILMAZ
Işıl YILDIRIM
Tülay ÇOBAN
Gülçin GÜLER ŞİMŞEK
Serpil OĞUZTÜZÜN
Pages
41–56
Publication Date
2021-01-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Objective: The aim of this study the investigation of "null" alleles in GSTM1 and GSTT1 gene regions in the development of COPD disease.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: The aim of this study the investigation of "null" alleles in GSTM1 and GSTT1 gene regions in the development of COPD disease.
📊
Key Findings & Data:Objective: The aim of this study the investigation of "null" alleles in GSTM1 and GSTT1 gene regions in the development of COPD disease.
💡
Conclusion & Impact:Objective: The aim of this study the investigation of "null" alleles in GSTM1 and GSTT1 gene regions in the development of COPD disease.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Deletion · GST Isozymes · COPD

Abstract

Objective: The aim of this study the investigation of "null" alleles in GSTM1 and GSTT1 gene regions in the development of COPD disease.

Özet

Amaç: Çalışmamızın amacı, KOAH hastalığının oluşumunda GSTM1 ve GSTT1 gen bölgesindeki “null” allellerinin rolü olup olmadığını araştırmaktır.

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Cite This Article

HAYAT, B., YAVUZ, M. S., ŞAHİN, M. E., DİRİCAN, O., YILMAZ, S., YILMAZ, C., YILDIRIM, I., ÇOBAN, T., ŞİMŞEK, G. G., OĞUZTÜZÜN, S. (2021). THE ROLE OF GLUTATION-S-TRANSFERASE MU1 AND TETA1 POLYMORPHISMS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, Cilt: 45 - Sayı: 1, 41–56. https://ajindex.com/articles/83245

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References (15)

  1. Celi BR, MacNee W. Standarts fort he diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur Respir J 2004; 23: 932
  2. Menezes AM, Perez-Padilla P, Jardim JR, et al. Chronic obstructive pulmonary disease in five Latin American cities (the PLATİNO study): a prevalence study. Lancet 2005; 366: 1875-81
  3. Gunen H, Hacievliyagil SS, Yetkin O, et al. Prevalence of COPD: first epidemiological study of a large region in Turkey. Eur J Intern Med 2008; 19: 499-504
  4. Oulette DR. The answer is fifteen percent: what is the question? Chest 2004;125:3-5
  5. Lozano R, Naghavi M, Foreman K, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012;380:2095-128. 6. http://www.who.int/respiratory/copd/burden/en/index.html (Erişim tarihi; 24.03.2010)
  6. Global Initiative for Chronic Obstructive Lung Disease: Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Pulmonary Disease (Güncelleme 2016)
  7. McGinnis JM, Williams-Russo P, Knickman JR. The case for more active policy attention to health promotion. Health Affairs 2012;21:78-93
  8. Hooper R, Burney P, Vollmer WM, et al. Risk factors for COPD spirometrically defined from the lower limit of normal in the BOLD Project. Eur Respir J 2012;39:1343-53
  9. Crawford EL, Khuder SA, Durham SJ, Frampton M, Utell M, Thilly WG, et al. Normal bronchial epithelial cell expression of glutathione transferase P1, glutathione transferase M3, and glutathione peroxidase is low in subjects with bronchogenic carcinoma. Cancer Res 2000: 60: 1609-18
  10. Han W, Pentecost BT, Pietropaolo RL, Fasco MJ, Spivack SD. Estrogen receptor alpha increases basal and cigarette smoke extract-induced expression of CYP1A1 and CYP1B1, but not GSTP1, in normal human bronchial epithelial cells. Mol Carcinog 2005; 44: 202-11
  11. Landi S. Mammalian class theta GST and differential susceptibility to carcinogens: a review. Mutat Res 2000; 463: 247-83
  12. Teramoto S
  13. COPD Pathogenesis from the Viewpoint of Risk Factors. Japanese Journal of Medicine 2007: 46: 77-79
  14. Ding Z, Wang K, Li J, Tan Q, Tan W, Guo G. Association between glutathione S-transferase gene M1 and T1 polymorphisms and chronic obstructive pulmonary disease risk: a meta-analysis. Clin Genet 2019;95:53–62
  15. Hemimi NED, Attar MA, Abd Elwahab MA. Genetic Polymorphism Of Glutathione-S Transferase And Sus