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Journals / EMU Journal of Pharmaceutical Sciences / 2019 / Cilt: 2 - Sayı: 2

The metabolites of ellagitannin metabolism urolithins display various biological activities

Jale YUZUGULEN
Bahareh NOSHADİ
Karar SHUKUR
Mustafa Fethi SAHİN
Hayrettin Ozan GULCAN
Pages
102–110
Publication Date
2019-12-30
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This review has aimed to introduce the structure and metabolism related formation of different urolithins concomitant to their biological activities discovered so far in the literature.

📌 3 Key Takeaways

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Objective & Hypothesis:Dietary consumption to various nuts, berries, and particularly pomegranate is an important source of ellagitannins.
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Key Findings & Data:Urolithins (i.e., hydroxylated benzo[c]chromen-6-one analogues) have a greater absorption than the ellagitannins thus; greater bioavailability is of great significance.
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Conclusion & Impact:This review has aimed to introduce the structure and metabolism related formation of different urolithins concomitant to their biological activities discovered so far in the literature.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Urolithins · Ellagitannins · Metabolism

Abstract

Dietary consumption to various nuts, berries, and particularly pomegranate is an important source of ellagitannins. These molecules are particularly subject to gastrointestinal metabolism producing urolithins as their metabolites. Urolithins (i.e., hydroxylated benzo[c]chromen-6-one analogues) have a greater absorption than the ellagitannins thus; greater bioavailability is of great significance. Therefore, the biological activities obtained through the use of ellagitannin rich foods are mainly attributed tourolithins. These compounds possess a good peripheral distribution. In addition, some of their further metabolitescan penetrate to the central nervous system which, is of a topic of interest for CNS related pathologies. This review has aimed to introduce the structure and metabolism related formation of different urolithins concomitant to their biological activities discovered so far in the literature.

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Cite This Article

YUZUGULEN, J., NOSHADİ, B., SHUKUR, K., SAHİN, M. F., GULCAN, H. O. (2019). The metabolites of ellagitannin metabolism urolithins display various biological activities. EMU Journal of Pharmaceutical Sciences, Cilt: 2 - Sayı: 2, 102–110. https://ajindex.com/articles/829626

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