KaydedilenlerDerginizi ekleyin

Dergiler / EMU Journal of Pharmaceutical Sciences / 2019 / Cilt: 2 - Sayı: 2

The metabolites of ellagitannin metabolism urolithins display various biological activities

Jale YUZUGULEN
Bahareh NOSHADİ
Karar SHUKUR
Mustafa Fethi SAHİN
Hayrettin Ozan GULCAN
Sayfa
102–110
Yayın Tarihi
2019-12-30
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

This review has aimed to introduce the structure and metabolism related formation of different urolithins concomitant to their biological activities discovered so far in the literature.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Dietary consumption to various nuts, berries, and particularly pomegranate is an important source of ellagitannins.
📊
Temel Bulgular & Veri:Urolithins (i.e., hydroxylated benzo[c]chromen-6-one analogues) have a greater absorption than the ellagitannins thus; greater bioavailability is of great significance.
💡
Sonuç & Katkı:This review has aimed to introduce the structure and metabolism related formation of different urolithins concomitant to their biological activities discovered so far in the literature.
🔬Tür:Literatür & Derleme Çalışması
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Urolithins · Ellagitannins · Metabolism

Abstract

Dietary consumption to various nuts, berries, and particularly pomegranate is an important source of ellagitannins. These molecules are particularly subject to gastrointestinal metabolism producing urolithins as their metabolites. Urolithins (i.e., hydroxylated benzo[c]chromen-6-one analogues) have a greater absorption than the ellagitannins thus; greater bioavailability is of great significance. Therefore, the biological activities obtained through the use of ellagitannin rich foods are mainly attributed tourolithins. These compounds possess a good peripheral distribution. In addition, some of their further metabolitescan penetrate to the central nervous system which, is of a topic of interest for CNS related pathologies. This review has aimed to introduce the structure and metabolism related formation of different urolithins concomitant to their biological activities discovered so far in the literature.

🔖

Bu Makaleye Atıf Yap

YUZUGULEN, J., NOSHADİ, B., SHUKUR, K., SAHİN, M. F., GULCAN, H. O. (2019). The metabolites of ellagitannin metabolism urolithins display various biological activities. EMU Journal of Pharmaceutical Sciences, Cilt: 2 - Sayı: 2, 102–110. https://ajindex.com/articles/829626

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (6)

  1. Abe LT, Lajolo FM, Genovese MI (2010). Comparison of phenol content and antioxidant capacity of nuts. Food Science and Technology 30: 254-259.
  2. Ahmed AH, Subaiea GM, Eid A, Li L, Seeram NP, Zawia NH (2014). Pomegranate extract modulates processing of amyloid-β precursor protein in an aged Alzheimer’s disease animal model. Curr. Alzheimer Res 11: 834−843. Bialonska D, Kasimsetty SG, Khan SI, Ferreira D (2009). Urolithins, intestinal microbial metabolites of pomegranate ellagitannins, exhibit potent antioxidant activity in a cell-based assay. J Agric Food Chem 57(21): 10181-10186.
  3. Bialonska D, Ramnani P, Kasimsetty SG, Muntha KR, Gibson GR, Ferreira D (2010). The influence of pomegranate by-product and punicalagins on selected groups of human intestinal microbiota. Int J Food Microbiol 140(2-3): 175-182. Cerdá B, Espín JC, Parra S, Martínez P, Tomás-Barberán FA (2004) The potent in vitro antioxidant ellagitannins from pomegranate juice are metabolised into bioavailable but poor antioxidant hydroxy-6H-dibenzopyran-6-one derivatives by the colonic microflora of healthy humans. Eur J Nutr 43(4): 205-20. Cerdá, B, Tomás-Barberán FA, Espín JC (2005). Metabolism of antioxidant and chemopreventive ellagitannins from strawberries, raspberries, walnuts, and oak-aged wine in humans: identification of biomarkers and individual variability. J Agric Food Chem 53: 227–235.
  4. Clifford MN, Scalbert A (2000). Ellagitannins–nature, occurrence and dietary burden. J Sci Food Agr 80(7): 1118-1125.
  5. Dell'Agli M, Galli GV, Bulgari M, Basilico N, Romeo S, Bhattacharya D, Taramelli D, Bosisio E (2010). Ellagitannins of the fruit rind of pomegranate (Punica granatum) antagonize in vitro the host inflammatory response mechanisms involved in the onset of malaria. Malar J 9(1): 208. Eghbaliferiz S and Iranshahi M (2016). Prooxidant activity of polyphenols, flavonoids, anthocyanins and carotenoids: updated review of mechanisms and catalyzing metals. Phytother Res 30(9): 1379-1391. Espín JC, Larrosa M, García-Conesa MT, Tomás-Barberán F (2013). Biological significance of urolithins, the gut microbial ellagic acid-derived metabolites: the evidence so far Evid Based Complement Alternat Med 270418. García-Villalba R, Beltrán D, Espín JC, Selma MV, Tomás-Barberán FA (2013). Time course production of urolithins from ellagic acid by human gut microbiota. J Agric Food Chem 61(37): 8797-8806.
  6. Garcia-Villalba R, Espín JC, Aaby K, Alasalvar C, Heinonen M, Jacobs G, Voorspoels S, Koivumäki T, Kroon P