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Journals / EMU Journal of Pharmaceutical Sciences / 2026 / Volume: 9 Issue: 2

Hepatoprotective Influence of Linalool Against Imatinib-Induced Hepatic Injury In Balb/C Mice

Olaniyi Ola(Abiola Ajimobi Technical University Ibadan, Nigeria)0000-0003-1510-4905
Oyindamola Abatan(Ajayi Crowther University, PMB 1066, Oyo, Oyo State, Nigeria.)0009-0002-4212-4709
Tajudeen Owolarafe(Nigeria Police Academy Wudil Kano Nigeria.)
Pages
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Publication Date
2026-09-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Overall, linalool abrogative influence improved liver damage occasioned by IMTB-mediated toxicities in mice by alleviating oxidative stress resulting from imatinib administration.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Imatinib (IMTB), a first-generation tyrosine kinase inhibitor, that is used to treat chronic myeloid leukemia has however been implicated in hepatic injury.
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Key Findings & Data:This study investigated the hepatoprotective potential of linalool against imatinib-induced toxicity in male BALB/c mice. 30 male BALB/c mice were randomly divided into five groups: I, control; II, olive oil (0.1ml olive oil); III, IMTB (400 mg/kg b.w.); IV, IMTB (400 mg/kg B.W.) + LN (40 mg/kg B.W.) simultaneously administered and V, LN (40 mg/kg b.w.).
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Conclusion & Impact:Overall, linalool abrogative influence improved liver damage occasioned by IMTB-mediated toxicities in mice by alleviating oxidative stress resulting from imatinib administration.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Imatinib · Linalool · hepatotoxicity

Abstract

Imatinib (IMTB), a first-generation tyrosine kinase inhibitor, that is used to treat chronic myeloid leukemia has however been implicated in hepatic injury. Linalool is a natural monoterpene alcohol with strong biologic antioxidant property. This study investigated the hepatoprotective potential of linalool against imatinib-induced toxicity in male BALB/c mice. 30 male BALB/c mice were randomly divided into five groups: I, control; II, olive oil (0.1ml olive oil); III, IMTB (400 mg/kg b.w.); IV, IMTB (400 mg/kg B.W.) + LN (40 mg/kg B.W.) simultaneously administered and V, LN (40 mg/kg b.w.). The result showed that simultaneous treatment with linalool significantly reduces AST, ALT and ALP activities compared to the IMTB group. Moreover, linalool abrogated IMTB-induced increase in advanced oxidation protein products and abated IMTB-facilitated surge decrease in total thiol levels and arylesterase activity. Additionally, linalool prevented pathological lesions and imatinib-induced necrotic influence in the liver of co-treated mice. Overall, linalool abrogative influence improved liver damage occasioned by IMTB-mediated toxicities in mice by alleviating oxidative stress resulting from imatinib administration.

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Cite This Article

Ola, O., Abatan, O., Owolarafe, T. (2026). Hepatoprotective Influence of Linalool Against Imatinib-Induced Hepatic Injury In Balb/C Mice. EMU Journal of Pharmaceutical Sciences, Volume: 9 Issue: 2. https://doi.org/10.54994/emujpharmsci.1968589

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