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Journals / Sağlık Akademisi Kastamonu / 2022 / Cilt: 7 - Sayı: 2

The relationship between Thiol/disulfide homeostasis and endometrial hyperplasia in patients with abnormal uterine bleeding/

Anormal uterin kanamalı kadınlarda endometrial hiperplazi ve thiol disülfat homeostazis ilişkisi

Sezin ERTÜRK AKSAKAL
Elif Gülşah DİKTAŞ
Ramazan Erda PAY
Ömer Lütfi TAPISIZ
Burcu TİMUR
Vakkas KORKMAZ
Özcan EREL
Yaprak ÜSTÜN
Pages
340–351
Publication Date
2022-08-01
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion and Suggestions: The dynamic thiol/disulfide balance shifted to the disulfide side in women with endometrial hyperplasia.

📌 3 Key Takeaways

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Objective & Hypothesis:Introduction: The role of oxidative stress and antioxidant capacity in the development of endometrial hyperplasia (EH) is controversial.
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Key Findings & Data:Materials and Methods: In this prospective case-control study, patients with EH without atypia (HP group) (n=28), patients with nonhyperplasia (proliferative/secretory/irregular proliferative/irregular secretory endometrium) (non-HP group) (n=28), and 28 healthy women (control group) were included.
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Conclusion & Impact:Conclusion and Suggestions: The dynamic thiol/disulfide balance shifted to the disulfide side in women with endometrial hyperplasia.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Thiol-Disülfat homeostazis · Oksidatif stres · Atipisiz endometrial hiperplazi

Abstract

Introduction: The role of oxidative stress and antioxidant capacity in the development of endometrial hyperplasia (EH) is controversial. Aim: The study aimed to evaluate Thiol/disulfide Homeostasis and ischemia modified albumin (IMA) levels in patients with EH without atypia. Materials and Methods: In this prospective case-control study, patients with EH without atypia (HP group) (n=28), patients with nonhyperplasia (proliferative/secretory/irregular proliferative/irregular secretory endometrium) (non-HP group) (n=28), and 28 healthy women (control group) were included. The patient's clinical characteristics, serum Thiol/disulfide parameters, and IMA levels were compared between groups. Results: A total of 84 patients were included in the study. Patients’ mean age, BMI, and mean native thiol (-SH-), total thiol (-SH-+-SS-), disulfide (-SS-), and IMA levels were similar among the three groups. The -SS- /-SH- ratio was higher in the HP group than the non-HP group. -SS- /-SH-+-SS- ratio was higher in the HP group vs. the other two groups. The -SS- /-SH-+-SS ratio was higher in the HP group vs. the non-HP group. -SH-/ -SH-+-SS- ratio was lower in the HP group than in the non-HP group. ET was greater in the HP group than in the non-HP and control groups. ET was also significantly greater in the non-HP group vs. in the control group. -SS-/-SH- ratio was found to be predictive with 64% sensitivity and 68% specificity for EH (area under curve = 0.672, p = 0.01). Conclusion and Suggestions: The dynamic thiol/disulfide balance shifted to the disulfide side in women with endometrial hyperplasia.

Özet

Giriş: Endometrial hiperplazi gelişimde oksidatif stres ve antioksidan kapasitenin rolü tartışmalıdır. Giriş: Endometrial hiperplazi gelişimde oksidatif stres ve antioksidan kapasitenin rolü tartışmalıdır. Amaç: Çalışma, Basit atipisiz endometrial hiperplazili hastalarda thiol-disulfat homeostazis ve iskemi-modifiye albumin (IMA) seviyelerini değerlendirmeyi amaçlamıştır. Gereç ve Yöntemler: Prospektif vaka kontrol dizaynlı çalışmada, atipisiz endometrial hiperplazili (HP grup) (n=28) hastalar, nonhiperplazi (proliferatif/sekretuar/düzensiz proliferatif/düzensiz sekretuar endometrium) saptanan hastalar (non-HP grup) (n=28) ve 28 sağlıklı kadın (kontrol grubu) çalışmaya dahil edildi. Hastaların klinik özellikleri, Thiol-disulfat parametreleri ve IMA seviyeleri gruplar arasında karşılaştırıldı. Bulgular: Çalışmaya toplam 84 hasta dahil edildi. Hastaların ortalama yaş, BMI, mean native thiol (-SH-), total thiol (-SH-+-SS-), disulfide (-SS-) ve IMA seviyeleri 3 grup arasında benzerdi. -SS-/-SH- ve -SS-/-SH-+-SS oranı HP grubunda non-HP grubundan anlamlı yüksekti. -SS-/-SH-+-SS- oranı HP grubunda diğer iki gruptan anlamlı yüksekti. -SH-/-SH-+-SS- oranı Hp grubunda non-HP grubuna göre anlamlı düşüktü. Endometrial kalınlık (ET), HP grubunda, non-HP ve kontrol grubuna göre daha kalındı. ET non-HP grubunda, kontrol grubundan anlamlı kalındı. -SS-/-SH- oranı %64 sensitivite, %68 spesifite ile endometrial hiperplaziyi öngörmektedir. Sonuç ve Öneriler: Endometrial hiperplazili kadınlarda Dinamik thiol-disülfat dengesi disülfat tarafına kaymıştır.

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Cite This Article

AKSAKAL, S. E., DİKTAŞ, E. G., PAY, R. E., TAPISIZ, Ö. L., TİMUR, B., KORKMAZ, V., EREL, Ö., ÜSTÜN, Y. (2022). The relationship between Thiol/disulfide homeostasis and endometrial hyperplasia in patients with abnormal uterine bleeding/. Sağlık Akademisi Kastamonu, Cilt: 7 - Sayı: 2, 340–351. https://ajindex.com/articles/798124

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