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Journals / Journal of the Turkish Chemical Society Section A: Chemistry / 2021 / Cilt: 8 - Sayı: 1

Cytotoxic effects of Mannich bases via induction of caspase-3 pathway on human oral squamous cell carcinoma

Cem YAMALI
Halise İnci GÜL
Pages
187–194
Publication Date
2021-02-28
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These results may suggest that the apoptosis pathway may be one of the possible mechanisms of the actions and lead compound 7 can be subjected to further bioassays.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In anticancer drug research, there is a need for the synthesis of compounds with selective cytotoxicity compared to the drugs in the market.
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Key Findings & Data:The current study aimed to determine the cytotoxicities of the bis Mannich bases 1-9 towards human oral squamous cell carcinoma (OSCC).
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Conclusion & Impact:These results may suggest that the apoptosis pathway may be one of the possible mechanisms of the actions and lead compound 7 can be subjected to further bioassays.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Mannich · anticancer · apoptosis

Abstract

In anticancer drug research, there is a need for the synthesis of compounds with selective cytotoxicity compared to the drugs in the market. The current study aimed to determine the cytotoxicities of the bis Mannich bases 1-9 towards human oral squamous cell carcinoma (OSCC). Mannich bases showed cytotoxicity in low micromolar in the range of 1.7-27 µM against OSCC cell lines. The compounds 5 with the highest potency selectivity expression (PSE) value (318.1) and 7 with the highest tumor selectivity (TS) values (TS1:11.2, TS2:15.8) showed promising selective cytotoxicity towards cancer cell lines. According to Western blot analysis, representative compound 7 induced the activation of caspase-3 in HSC-2 cells. These results may suggest that the apoptosis pathway may be one of the possible mechanisms of the actions and lead compound 7 can be subjected to further bioassays.

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Cite This Article

YAMALI, C., GÜL, H. İ. (2021). Cytotoxic effects of Mannich bases via induction of caspase-3 pathway on human oral squamous cell carcinoma. Journal of the Turkish Chemical Society Section A: Chemistry, Cilt: 8 - Sayı: 1, 187–194. https://ajindex.com/articles/781164

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