SavedAdd your journal

Journals / International Journal of Science Letters / 2022 / Cilt: 4 - Sayı: 1

miRNAs as biomarkers in human diseases

Rümeysa KARAİSMAİLOĞLU
Sevgi MARAKLI
Pages
190–201
Publication Date
2022-02-07
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this review, after a brief description, we discuss the use of miRNAs for diagnosis and prognosis as biomarkers and biosensors in addition to miRNA-based therapies.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:RNA interference (RNAi) is one of the primary machineries involved in the regulation of gene expression using small double-stranded RNA (dsRNA) in eukaryotic cells.
📊
Key Findings & Data:Previous studies have shown that miRNA coding sequences make up 1% of the human genome and currently 1917 human miRNAs are displayed in the miRBase database.
💡
Conclusion & Impact:In this review, after a brief description, we discuss the use of miRNAs for diagnosis and prognosis as biomarkers and biosensors in addition to miRNA-based therapies.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Biomarker · Biosensor · Gene Expression Regulation

Abstract

RNA interference (RNAi) is one of the primary machineries involved in the regulation of gene expression using small double-stranded RNA (dsRNA) in eukaryotic cells. MicroRNA (miRNA) is a class of small non-coding RNAs, regulating gene expression through canonical and non-canonical ways. Previous studies have shown that miRNA coding sequences make up 1% of the human genome and currently 1917 human miRNAs are displayed in the miRBase database. Expression levels of circulating miRNAs are related to various pathophysiological conditions such as cancer, infectious conditions, cardiovascular diseases, neurodegenerative diseases, and many more. Therefore, it is important to identify, detect and analyse miRNAs by using in silico and experimental analyses. In this review, after a brief description, we discuss the use of miRNAs for diagnosis and prognosis as biomarkers and biosensors in addition to miRNA-based therapies.

🔖

Cite This Article

KARAİSMAİLOĞLU, R., MARAKLI, S. (2022). miRNAs as biomarkers in human diseases. International Journal of Science Letters, Cilt: 4 - Sayı: 1, 190–201. https://ajindex.com/articles/768454

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. Aghili, Z., Nasirizadeh, N., Divsalar, A., Shoeibi, S., Yaghmaei, P. 2018. A highly sensitive miR-195 nano biosensor for early detection of Parkinson’s disease. Artificial Cells, Nanomedicine, and Biotechnology, 46(sup1), 32-40.
  2. Almeida, R., Allshire, R. C. 2005. RNA silencing and genome regulation. Trends in Cell Biology, 15(5), 251–258.
  3. Altschul, S. F., Gish, W., Miller, W., Myers, E. W. et al. 1990. Basic local alignment search tool. Journal of Molecular Biology, 215(3), 403-410.
  4. Axtell, M. J., Bowman, J. L. 2008. Evolution of plant microRNAs and their targets. Trends in plant science, 13(7), 343-349.
  5. Bartel, D. P. 2004. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell, 116(2), 281-297.
  6. Bartel, D. P., Chen, C. Z. 2004. Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs. Nature Reviews Genetics, 5(5), 396-400.
  7. Bartlett, B., Gao, Z., Schukking, M., Menor, M., Khadka, V. S. et al. 2021. The miRNA profile of inflammatory colorectal tumors identify TGF-β as a companion target for checkpoint blockade immunotherapy. Frontiers in Cell and Developmental Biology, 9, 754507. Berner, K., Hirschfeld, M., Weiß, D., Rücker, G., Asberger, J. et al. 2021. Evaluation of circulating microRNAs as non-invasive biomarkers in the diagnosis of ovarian cancer: A case-control study. Archives Of Gynecology and Obstetrics, 10.1007/s00404-021-06287-1.
  8. Bhardwaj, A., Arora, S., K Prajapati, V., Singh, S., P Singh, A. 2013. Cancer “stemness”-regulating microRNAs: role, mechanisms and therapeutic potential. Current drug targets, 14(10), 1175-1184.
  9. Biswas, S., Haleyurgirisetty, M., Lee, S., Hewlett, I., Devadas, K. 2019. Development and validation of plasma miRNA biomarker signature panel for the detection of early HIV-1 infection. EBioMedicine, 43, 307-316.
  10. Brüggenwirth, I. M., Martins, P. N. 2020. RNA interference therapeutics in organ transplantation: The dawn of a new era. American Journal of Transplantation, 20(4), 931-941.
  11. Castel, S. E., Martienssen, R. A. 2013. RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond. Nature Reviews Genetics, 14(2), 100-112.
  12. Chen, C., Ridzon, D. A., Broomer, A. J., Zhou, Z., Lee, D. H. et al. 2005. Real-time quantification of microRNAs by stem–loop RT–PCR. Nucleic Acids Research, 33(20), e179-e179. Chetta, M., Di Pietro, L., Bukvic, N., Lattanzi, W. 2020. Rising roles of small noncoding RNAs in cotranscriptional regulation: In silico study of miRNA and p