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Dergiler / International Journal of Science Letters / 2022 / Cilt: 4 - Sayı: 1

miRNAs as biomarkers in human diseases

Rümeysa KARAİSMAİLOĞLU
Sevgi MARAKLI
Sayfa
190–201
Yayın Tarihi
2022-02-07
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

In this review, after a brief description, we discuss the use of miRNAs for diagnosis and prognosis as biomarkers and biosensors in addition to miRNA-based therapies.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:RNA interference (RNAi) is one of the primary machineries involved in the regulation of gene expression using small double-stranded RNA (dsRNA) in eukaryotic cells.
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Temel Bulgular & Veri:Previous studies have shown that miRNA coding sequences make up 1% of the human genome and currently 1917 human miRNAs are displayed in the miRBase database.
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Sonuç & Katkı:In this review, after a brief description, we discuss the use of miRNAs for diagnosis and prognosis as biomarkers and biosensors in addition to miRNA-based therapies.
🔬Tür:Literatür & Derleme Çalışması
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Biomarker · Biosensor · Gene Expression Regulation

Abstract

RNA interference (RNAi) is one of the primary machineries involved in the regulation of gene expression using small double-stranded RNA (dsRNA) in eukaryotic cells. MicroRNA (miRNA) is a class of small non-coding RNAs, regulating gene expression through canonical and non-canonical ways. Previous studies have shown that miRNA coding sequences make up 1% of the human genome and currently 1917 human miRNAs are displayed in the miRBase database. Expression levels of circulating miRNAs are related to various pathophysiological conditions such as cancer, infectious conditions, cardiovascular diseases, neurodegenerative diseases, and many more. Therefore, it is important to identify, detect and analyse miRNAs by using in silico and experimental analyses. In this review, after a brief description, we discuss the use of miRNAs for diagnosis and prognosis as biomarkers and biosensors in addition to miRNA-based therapies.

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Bu Makaleye Atıf Yap

KARAİSMAİLOĞLU, R., MARAKLI, S. (2022). miRNAs as biomarkers in human diseases. International Journal of Science Letters, Cilt: 4 - Sayı: 1, 190–201. https://ajindex.com/articles/768454

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Kaynakça (12)

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