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Journals / International Anatolia Academic Online Journal Health Sciences / 2021 / Cilt: 7 - Sayı: 3

Comparison of Laboratory Findings And Mortalıty Rates of Varıant ALPHA and SARS-COV-2 Infected Patients

Varyant ALFA VE SARS-COV-2 Enfekte Hastaların Laboratuvar Bulgularının ve Mortalite Oranlarının Karşılaştırılması

Adem KESKİN
Recai ACİ
Mehmet Hakan TAŞKIN
Mukadder ERDEM
Melek BİLGİN
Murat ARI
Pages
79–88
Publication Date
2021-12-30
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The reason that there was no difference in mortality rate between the groups may be the higher PT and INR values of the SARS-CoV-2 group.

📌 3 Key Takeaways

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Objective & Hypothesis:In our study, the common laboratuvary findings affecting SARS-CoV-2 patient outcomes were designed on the levels detected in Variant Alpha patients. 115 Variant Alpha inpatients, 115 SARS-CoV-2 inpatients and 111 healthy individuals were included in this study.
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Key Findings & Data:Variant Alpha White Blood Cell (WBC), Platelet, Neutrophil, Lymphocyte, Monocyte count, Neutrophil Lymphocyte Ratio(NLR), Monocyte Lymphocyte Ratio (MLR), Hemoglobin, Procalcitonin, C-reactive protein (CRP), Ferritin, Prothrombin Time (PT), activated Partial Thromboplastin Time (aPTT), International Normalized Ratio(INR), D-dimer levels and SARS-CoV-2 patients levels were compared.
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Conclusion & Impact:The reason that there was no difference in mortality rate between the groups may be the higher PT and INR values of the SARS-CoV-2 group.
🔬Design:Lab & Field Experiment
📍Scope:Comprehensive Sample
⚙️Variables:Varyant Alfa · SARS-CoV-2 · Ölüm Oranı

Abstract

In our study, the common laboratuvary findings affecting SARS-CoV-2 patient outcomes were designed on the levels detected in Variant Alpha patients. 115 Variant Alpha inpatients, 115 SARS-CoV-2 inpatients and 111 healthy individuals were included in this study. Variant Alpha White Blood Cell (WBC), Platelet, Neutrophil, Lymphocyte, Monocyte count, Neutrophil Lymphocyte Ratio(NLR), Monocyte Lymphocyte Ratio (MLR), Hemoglobin, Procalcitonin, C-reactive protein (CRP), Ferritin, Prothrombin Time (PT), activated Partial Thromboplastin Time (aPTT), International Normalized Ratio(INR), D-dimer levels and SARS-CoV-2 patients levels were compared. This comparison also includes comparison with the levels of healthy individuals. WBC, Neutrophil, MLR, NLR, PCT (p=0.037), Ferritin, CRP, aPTT, D-dimer levels of the Variant Alpha group were higher than the levels of SARS-CoV-2 group, and Lymphocyte (p=0.001), PT, INR levels of the Variant Alpha group were lower than the levels of SARS-CoV-2 group (p<0.001). There was no difference between the mortality rates observed in the Variant Alpha group and the SARS-CoV-2 group (p>0.05). In terms of laboratory findings, Variant Alpha patients experience more severe disease than SARS-CoV-2 patients. The reason that there was no difference in mortality rate between the groups may be the higher PT and INR values of the SARS-CoV-2 group.

Özet

Çalışmamız, SARS-CoV-2 hasta sonuçlarını etkileyen yaygın laboratuvar bulgularının, Varyant Alfa hastalarında tespit edilen düzeyleri üzerine tasarlanmıştır. Bu çalışmaya 115 Varyant Alfa yatan hasta, 115 SARS-CoV-2 yatan hasta ve 111 sağlıklı birey dahil edildi. Varyant Alfa hastaların Beyaz Kan Hücresi (WBC), Trombosit, Nötrofil, Lenfosit, Monosit sayısı, Monosit Lenfosit Oranı (MLR), Nötrofil Lenfosit Oranı (NLR), Hemoglobin, Prokalsitonin, C-reaktif protein (CRP), Ferritin, Protrombin Zamanı (PT), Aktive Parsiyel Tromboplastin Zamanı (aPTT), D-dimer, International Normalized Ratio (INR) seviyeleri SARS-CoV-2 hasta seviyeleri karşılaştırıldı. Bu karşılaştırma aynı zamanda sağlıklı bireylerin seviyeleri ile karşılaştırmayı da içerir. Varyant Alfa grubunun WBC, Nötrofil, MLR, NLR, PCT (p=0.037), Ferritin, CRP, aPTT, D-dimer seviyeleri SARS-CoV-2 grubunun seviyelerinden önemli ölçüde yüksekti (p=0.001). Ayrıca, Varyant Alfa grubunun Lenfosit, PT, INR seviyeleri SARS-CoV-2 grubunun seviyelerinden anlamlı derecede düşüktü (p<0.001). Varyant Alfa grubunda ve SARS-CoV-2 grubunda gözlemlenen ölüm oranları arasında anlamlı bir fark yoktu. Laboratuvar bulguları açısından Varyant Alfa hastaları SARS-CoV-2 hastalarına göre daha şiddetli hastalık yaşamaktadır. Gruplar arasında ölüm oranı farkı olmamasının nedeni, SARS-CoV-2 grubunun PT ve INR değerlerinin yüksek olması olabilir.

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Cite This Article

KESKİN, A., ACİ, R., TAŞKIN, M. H., ERDEM, M., BİLGİN, M., ARI, M. (2021). Comparison of Laboratory Findings And Mortalıty Rates of Varıant ALPHA and SARS-COV-2 Infected Patients. International Anatolia Academic Online Journal Health Sciences, Cilt: 7 - Sayı: 3, 79–88. https://ajindex.com/articles/764581

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References (9)

  1. Public Health England. Investigation of novel SARS-CoV-2 variant: variant of concern 202012/01, technical briefing 3. London, United Kingdom: Public Health England; 2020.
  2. World Health Organization, Tracking SARS-CoV-2 variants. (Access Date: 03 October 2021). Access Address: https://www.who.int/en/activities/tracking-SARS-CoV-2-variants/
  3. Frampton D, Rampling T, Cross A, Bailey H, Heaney J, Byott M, et al. Genomic characteristics and clinical effect of the emergent SARS-CoV-2 B.1.1.7 lineage in London, UK: a whole-genome sequencing and hospital-based cohort study. The Lancet Infectious Diseases 2021;21(9):1246-1256.
  4. Galloway SE, Paul P, MacCannell DR, Johansson MA, Brooks JT, MacNeil A, et al. Emergence of SARS-CoV-2 B.1.1.7 Lineage —United States, December 29, 2020–January 12, 2021. MMWR Morb Mortal Wkly Rep. 2021;70(3): 95-99.
  5. Vidali S, Morosetti D, Cossu E, Luisi MLE, Pancani S, Semeraro V, et al. D-dimer as an indicator of prognosis in SARS-CoV-2 infection: a systematic review. ERJ Open Research. 2020;6(2):00260-2020.
  6. Singh K, Mittal S, Gollapudi S, Butzmann A, Kumar J, Ohgami RS. A meta-analysis of SARS-CoV-2 patients identifies the combinatorial significance of D-dimer, C-reactive protein, lymphocyte, and neutrophil values as a predictor of disease severity. ISLH. 2021;43(2):324-328.
  7. Washington NL, Gangavarapu K, Zeller M, Bolze A, Cirulli ET, Barrett KMS, et al. Genomic epidemiology identifies emergence and rapid transmission of SARS-CoV-2 B.1.1.7 in the United States. medRxiv. 2021.02.06;21251159. Skevaki C, Fragkou PC, Cheng C, Xie M, Renz H. Laboratory characteristics of patients infected with the novel SARS-CoV-2 virus. Journal of Infection. 2020;81(2):205–212.
  8. Huang G, Kovalic AJ, Graber CJ. Prognostic Value of Leukocytosis and Lymphopenia for Coronaviru Liu Y, Du X, Chen J, Jin Y, Peng L, Wang HHX, et al. Neutrophil-to-lymphocyte ratio as an independent risk factor for mortality in hospitalized patients with COVID-19. Journal of Infection. 2020;81(1):e6–e12.s Disease Severity. Emerg Infect Dis. 2020;26(8):1839-1841.
  9. Liu Y, Du X, Chen J, Jin Y, Peng L, Wang HHX, et al. Neutrophil-to-lymphocyte ratio as an independent risk factor for mortality in hospitalized patients with COVID-19. Journal of Infection. 2020;81(1):e6–e12. Dávila-Collado R, Jarquín-Durán O, Solís-Vallejo A, Nguyen MA, Espinoza JL. Elevated Monocyte to Lymphocyte Ratio and Increased Mortality among Patients with Chronic Kidney Disease Hospitalized for COVID-19. J. Pers. Med. 2021;