SavedAdd your journal

Journals / Hacettepe Üniversitesi Eczacılık Fakültesi Dergisi / 2006 / Sayı: 2

Cytotoxic Activity on Some Verbascum Species Growing in Turkey

Türkiye’de Yetişen Bazı Verbascum Türlerinin Sitotoksik Aktivitesi

İ. İrem TATLI
Zeliha S. AKDEMİR
Pages
77–86
Publication Date
2006-06-01
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Through bioassay-guided fractionation on the methanol extract of this species, seven fractions were obtained; however, none of the fractions had cytotoxic activity against cancer cell lines.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:V. chionophyllum, V. cilicicum, V. pterocalycinum var. mutense, V. pycnostachycum and V. splendidum Scrophulariaceae were studied for their cytotoxic activities against SK-MEL, KB, BT-549, and SK-OV-3 cell lines.
📊
Key Findings & Data:The results were evaluated to compare cytotoxic activity in both their methanol and ethylacetate extracts.
💡
Conclusion & Impact:Through bioassay-guided fractionation on the methanol extract of this species, seven fractions were obtained; however, none of the fractions had cytotoxic activity against cancer cell lines.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Verbascum türleri · Scrophulariaceae · Sitotoksik aktivite

Abstract

V. chionophyllum, V. cilicicum, V. pterocalycinum var. mutense, V. pycnostachycum and V. splendidum Scrophulariaceae were studied for their cytotoxic activities against SK-MEL, KB, BT-549, and SK-OV-3 cell lines. The results were evaluated to compare cytotoxic activity in both their methanol and ethylacetate extracts. The methanol extract of the flowers of V. pterocalycinum var. mutense showed a weak cytotoxic activity against SK-MEL cell line. Through bioassay-guided fractionation on the methanol extract of this species, seven fractions were obtained; however, none of the fractions had cytotoxic activity against cancer cell lines.

Özet

V. chionophyllum, V. cilicicum, V. pterocalycinum var. mutense, V. pycnostachycum ve V. splendidum Scrophulariaceae ’un, SK-MEL, KB, BT-549 ve SK-OV-3 kanser hücrelerine karşı sitotoksik aktiviteleri çalışılmıştır. Sonuçlar, bu türlerin metanol ve etil asetat ekstrelerinin sitotoksik aktiviteleri karşılaştırılarak değerlendirilmiştir. V. pterocalycinum var. mutense çiçeklerinin metanol ekstresi, SK-MEL kanser hücresine karşı zayıf sitotoksik aktivite göstermiştir. Bu türün metanol ekstresi üzerinde yapılan biyolojik rehberli fraksiyonlama ile yedi fraksiyon elde edilmiş, ancak, fraksiyonların hiçbirisi sitotoksik aktivite göstermemiştir.

🔖

Cite This Article

TATLI, İ. İ., AKDEMİR, Z. S. (2006). Cytotoxic Activity on Some Verbascum Species Growing in Turkey. Hacettepe Üniversitesi Eczacılık Fakültesi Dergisi, Sayı: 2, 77–86. https://ajindex.com/articles/762448

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Lee, K. H.: Novel antitumor agents from higher plants, Medicinal Research Reviews, 19 (6), 569-596 (1999).
  2. Huber-Morath, A. Verbascum, in “Flora of Turkey and the East Aegean Islands” (edited by P.H. Davis), Edinburgh, University Press, Vol. 6, 461 (1978).
  3. Baytop, T.: Therapy with Medicinal Plants in Turkey (Past and Present), Istanbul, Nobel Tıp Kitabevleri Ltd., 2nd ed., 334 (1999).
  4. Ucar-Turker, A., Camper, N.D.: Biological activity of common mullein, a medicinal plant, J. Ethnopharmacol., 82, 117 (2002).
  5. Ionkova, I., Alferman, A.: Use of DNA for detection and isolation of potential anticancer agents from plants. Farmatsiya, 47, 10 (2000).
  6. Itokawa, H., Takeya, K.: Antitumor sunstances from higher plants. Heterocycles, 35, 1467 (1993).
  7. Borenfreund, E., Babich, H., Martin-Alguacil, N.: Rapid chemosensitivity assay with human normal and tumor cells in vitro, In Vitro Cell. Dev. Biol., 26, 1030 (1990).
  8. Dou, J., McChesney, J.D., Sindelar, R.D., Goins, D.K., walker, L.A.: A new quassinoid from Castela texana, J. Nat. Prod., 59, 73 (1996).
  9. Muhammad, I., Dunbar, D.C., Khan, R.A., Ganzera, M., Khan, I.A.: Investigation of Una De Gato I. 7-deoxyloganic acid and 15N NMR spectroscopic studies on pentacyclic oxindole alkaloids from Uncaria tomentosa, Phytochemistry, 57, 781 (2001).
  10. Muhammad, I., Bedir, E., Khan, S.I., Tekwani, B.L., Khan, I.A., Takamatsu, S., Pel- letier, J., walker, L.A.: A new antimalarial quassinoid from Simaba orinocensis, J. Nat. Prod., 67, 772 (2004).
  11. Afifi, M.S.A., Ahmed, M.M., Pezzuto, J.M., Kinghorn, A.D.: Cytotoxic flavonolignans and flavones from Verbascum sinaiticum leaves, Phytochemistry, 34, 839 (1993).
  12. Klimek, B., Stepien, H.: Effect on some constituents of mullein (Verbascum sp.) on proliferation of rat splenocytes in vitro, Eur. J. Pharm. Sci., 2 (1-2), 123 (1994).
  13. Paszkiewicz-Gadek, A., Grochowska, K., Galasinski, w.: Effect of the aqueous extract and saponin fraction from the flowers of Verbascum thapsiforme on protein biosynthe- sis in a rat liver ribosomal system, Phytother. Res., 4, 177 (1990).
  14. Lin, L.T., Liu, L.T., Chiang, L. C., Lin, Cc.: In vitro Anti-hepatoma Activity of Fifteen Natural Medicines from Canada, Phytother. Res., 16, 440 (2002).
  15. Itokawa, H., Takeya, K., Mori, N., Sonobe, T., Mihashi, S., Hamanaka, T.: Studies on antitumor cyclic hexapeptides Ra obtained from Rubia Radix, Rubiaceae. 6. Minor an- titumor constituents. Chem. Pharm. Bull., 34, 3762 (1986).
  16. Saracoglu, I., Inoue, M., Calis, I., Ogihara, Y.: Studies on