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Journals / Hacettepe Üniversitesi Eczacılık Fakültesi Dergisi / 2026 / Volume: 46 Issue: 3

Plant Sterols and Metabolic Health: Current Evidence on Insulin Resistance and Type 2 Diabetes Mellitus

Partha Deb Roy(JSS College of Pharmacy)0009-0006-1495-0498
Vadivelan Ramachandran(JSS College of Pharmacy,Ooty)0000-0001-7927-4554
Tharani M(Indira Gandhi Institute of Pharmaceutical Sciences)0000-0001-7465-1525
Kalirajan Rajagopal(JSS College of Pharmacy, Ooty)0000-0003-3382-4316
Venkatesh Gunasekaran(PSG College of Pharmacy)0000-0002-4057-520X
Ruchı Tıwarı(Pranveer Singh institute of Technology (Pharmacy))0000-0001-6897-3472
Pages
—
Publication Date
2026-09-01
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Current findings strongly support the lipid-lowering benefits of phytosterols, where as their role in glycemic control requires further validation through well-designed clinical studies.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Plant sterols are naturally occurring bioactive compounds widely recognized for their cholesterol-lowering effects.
📊
Key Findings & Data:This narrative review critically evaluates current evidence regarding the role of phytosterols in insulin resistance, glucose metabolism, and type 2 diabetes mellitus (T2DM).
💡
Conclusion & Impact:Current findings strongly support the lipid-lowering benefits of phytosterols, where as their role in glycemic control requires further validation through well-designed clinical studies.
🔬Design:Review & Systematic Survey
📍Scope:2000 Verileri
⚙️Variables:Type 2 diabetes · phytosterols · cholesterol-lowering effects

Abstract

Plant sterols are naturally occurring bioactive compounds widely recognized for their cholesterol-lowering effects. This narrative review critically evaluates current evidence regarding the role of phytosterols in insulin resistance, glucose metabolism, and type 2 diabetes mellitus (T2DM). Literature was collected from PubMed, Scopus, and Google Scholar for studies Published between 2000 and 2024 using pre-defined keywords related to phytosterols, insulin resistance, and T2DM. Evidence from in-vitro and animal studies suggests that phytosterols may influence AMPK, PI3/Akt, and GLUT4 signaling pathways and may improve metabolic homeostasis. However, evidence from human clinical trials remains limited and in-consistent. Current findings strongly support the lipid-lowering benefits of phytosterols, where as their role in glycemic control requires further validation through well-designed clinical studies.

🔖

Cite This Article

Roy, P. D., Ramachandran, V., M, T., Rajagopal, K., Gunasekaran, V., Tıwarı, R. (2026). Plant Sterols and Metabolic Health: Current Evidence on Insulin Resistance and Type 2 Diabetes Mellitus. Hacettepe Üniversitesi Eczacılık Fakültesi Dergisi, Volume: 46 Issue: 3. https://doi.org/10.52794/hujpharm.1697229

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