Journals / Gazi Sağlık Bilimleri Dergisi / 2021 / Cilt: 6 - Sayı: 3

PROBIOTICS' NATURAL FOLATE SOURCE POTENTIAL: CURRENT OVERVIEW

PROBİYOTİKLERİN DOĞAL FOLAT KAYNAĞI POTANSİYELİ: GÜNCEL BAKIŞ

Pages
135–142
Publication Date
2021-12-24
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Nutrient fortification in this way can be a natural alternative to the use of synthetic folic acid.

📌 3 Key Takeaways

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Objective & Hypothesis:Folate is a basic micronutrient that is responsible for cell division and DNA synthesis and essential for maintaining vital activities.
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Key Findings & Data:Insufficient folat intake causes megaloblastic anemia, neural tube defect, cardiovascular diseases, growth reterdation, some neurological diseases such as alzheimer's and some types of cancer.
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Conclusion & Impact:Nutrient fortification in this way can be a natural alternative to the use of synthetic folic acid.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Probiyotik · Folik asit takviyesi · Besin zenginleştirme

Abstract

Folate is a basic micronutrient that is responsible for cell division and DNA synthesis and essential for maintaining vital activities. Insufficient folat intake causes megaloblastic anemia, neural tube defect, cardiovascular diseases, growth reterdation, some neurological diseases such as alzheimer's and some types of cancer. Folate deficiency is considered as an important public health problem around the world due to its role in the development of neural tube defects. Therefore, in many countries, neural tube defects are tried to be prevented by folic acid supplements or enriching foods with folic acid. The chemical form of folate is known as folic acid, and it is used in food supplements. Experimental studies have shown that consuming folic acid in high doses with this synthetic form has a negative effect on neuronal development. As a result, there are conflicting views on the safety of folic acid supplementation. In recent years, research has been conducted on the folate fortification of foods via fermentation of some probiotic bacteria. Nutrient fortification in this way can be a natural alternative to the use of synthetic folic acid.

Özet

Yaşamsal faaliyetlerin sürdürülmesi açısından önemli olan folat, hücre bölünmesi ve DNA sentezinde görevli olan temel bir mikrobesin ögesidir. Yetersiz folat alımı megaloblastik anemi, nöral tüp defektleri, kardiyovasküler hastalıklar, büyüme geriliği, alzheimer gibi bazı nörolojik hastalıklar ve bazı kanser türlerinin oluşumuna sebep olmaktadır. Folat yetersizliği, nöral tüp kusurlarına neden olması açısından tüm dünyada önemli bir halk sağlığı sorunu olarak görülmektedir. Bu yüzden bir çok ülkede, folik asit takviyesi veya gıdaların folik asit ile zenginleştirilmesi yoluyla nöral tüp defektlerinin önüne geçilmeye çalışılmaktadır. Folatın kimyasal formu; folik asit olarak isimlendirilmiştir ve gıda takviyelerinde bu sentetik olan formu kullanılmaktadır. Folik asitin bu sentetik şekliyle yüksek dozlarda tüketilmesinin nöronal gelişim üzerinde olumsuz etkilerinin gösterildiği deneysel çalışmalar bulunmaktadır. Bu nedenle folik asit takviyesinin güvenliği konusunda çelişkili yaklaşımlar mevcuttur. Son yıllarda bazı probiyotik bakterilerin fermentasyonu aracılığı ile gıdaların folat açısından zenginleştirilmesi üzerinde çalışmalar yapılmaktadır. Bu şekilde besinlerin zenginleştirilmesi, sentetik folik asit kullanımına karşı doğal bir alternatif olabilir.

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Cite This Article

DEMİRTAŞ, A. A., KAYAHAN, S., KARADAĞ, M. G. (2021). PROBIOTICS' NATURAL FOLATE SOURCE POTENTIAL: CURRENT OVERVIEW. Gazi Sağlık Bilimleri Dergisi, Cilt: 6 - Sayı: 3, 135–142. https://ajindex.com/articles/759679

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References (15)

  1. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev. 1997; (6)1:43-45
  2. Sanderson P, McNulty H, Mastroiacovo P, McDowell I.FW, Melse-Boonstra A, Finglas PM, et al. Folate bioavailability:UK food standards agency workshop report. Br J Nutr. 2003; 90(2):473–479
  3. Kok DE, Steegenga WT, McKay JA. Folate and epigenetics: why we should not forget bacterial biosynthesis. Epigenomics. 2018; 10(9):1147-1150
  4. Hanson AD, Gregory JF. Folate biosynthesis, turnover, and transport in plants. Annu Rev Plant Biol. 2011; 62:105-25
  5. Victor Herbert MD. Recommended dietary intakes (RDI) of folate in humans1-3, Am J Clin Nutr. 1987; 45(4):661-70
  6. T.C. Sağlık Bakanlığı, Türkiye Halk sağlığı Kurumu. Türkiye Beslenme Rehberi TÜBER Yayın No:1031, Ankara 2016. Erişim:https://okulsagligi.meb.gov.tr/meb_iys_dosyalar/2017_01/27102535_TYrkiye_Beslenme_Rehberi.pdf. (06.05.21
  7. Rossi M, Amaretti A, Raimondi S. Folate Production by Probiotic Bacteria. Nutrition. 2011; 3(1):118-134
  8. Rowland I, Gibson G, Heinken A, Scott K, Swann J, Thiele I, et al. Gut microbiota functions: metabolism of nutrients and other food components. Eur J Nutr. 2018; 57(1):1-24
  9. Asrar FM, O'Connor DL. Bacterially synthesized folate and supplemental folic acid are absorbed across the large intestine of piglets. J Nutr Biochem. 2005; 16(10):587–593
  10. D'Aimmoa M R, Modest M, Mattarelli P, Biavat B, Andlid T. Biosynthesis and cellular content of folate in bifidobacteria across hostspecies with different diets. Anaerobe. 2014; 30:169-177
  11. LeBlanc JG, Laino JE, Juarez del Valle M, Vannini V, Van Sinderen D,Taranto MP, et al. B-Group vitamin production by lactic acid bacteria – current knowledge and potential applications. J Appl Microbiol. 2011; 111(6):1297-309
  12. Leroy F, De Vuyst L, Lactic acid bacteria as functional starter cultures for the food fermentation industry. Trends Food Sci Technol. 2004; 15:67-68
  13. LeBlanc JG, Savoy de Giori G, Smid EJ, Hugenholtz J, Sesma F. Folate production by lactic acid bacteria and other food-grade microorganisms. J Appl Microbiol. 2007; 329-339
  14. Laiño JE, Valle MJ, Savoy de Giori, LeBlanc JG. Applicability of a Lactobacillus amylovorus strain as co-culture for natural folate bio-enrichment of fermented milk. Int J Food Microbiol. 2014; 191:10-16
  15. Khalili M, Rad AH, Khosroushahi AY, Khosravi H, Jafarzadeh S. Application of Probiotics in Folate Bio-Fortification of Yoghurt. Probiotics Antimicrob Proteins. 2020; 12(2