Journals / Anatolian Current Medical Journal / 2020 / Cilt: 2 - Sayı: 4

A case of azathioprine-associated Sweet syndrome with ulcerative colitis and psoriasis

Ülseratif kolit ve psöriazis ile birlikte azathioprin ilişkili Sweet sendromu olgusu

Pages
142–144
Publication Date
2020-09-23
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In such cases, it is important to take Sweet's syndrome into consideration and discontinue the drug in the early period and start appropriate treatment.

📌 3 Key Takeaways

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Objective & Hypothesis:Sweet syndrome is a rare dermatosis characterized by painful erythematous plaques, fever, arthralgia, peripheral leukocytosis, edema in the upper dermis, and intense neutrophil infiltration.
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Key Findings & Data:The syndrome can be seen together with upper respiratory tract infections, hematological malignancies, drug hypersensitivity, sarcoidosis, autoimmune diseases as well as idiopathic.
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Conclusion & Impact:In such cases, it is important to take Sweet's syndrome into consideration and discontinue the drug in the early period and start appropriate treatment.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Sweet sendromu · azathioprin · ülseratif kolit

Abstract

Sweet syndrome is a rare dermatosis characterized by painful erythematous plaques, fever, arthralgia, peripheral leukocytosis, edema in the upper dermis, and intense neutrophil infiltration. The syndrome can be seen together with upper respiratory tract infections, hematological malignancies, drug hypersensitivity, sarcoidosis, autoimmune diseases as well as idiopathic. In patients with ulcerative colitis and psoriasis using azathioprine, emerging skin lesions may be an exacerbation of the underlying autoimmune disease, and rarely may also be azathioprine-induced hypersensitivity syndrome. In such cases, it is important to take Sweet's syndrome into consideration and discontinue the drug in the early period and start appropriate treatment.

Özet

Sweet sendromu ağrılı eritematöz plaklar, ateş, artralji, periferik lökositoz, üst dermiste ödem ve yoğun nötrofil infiltrasyonu ile karakterize nadir görülen bir dermatozdur. Sendrom, üst solunum yolu enfeksiyonları, hematolojik maligniteler, ilaç hipersensitivitesi, sarkoidoz, otoimmün hastalıklar ile birlikte görülebildiği gibi idiyopatik de olabilir. Azatiopurin kullanan ülseratif kolit ve psöriazis hastalarında yeni gelişen cilt lezyonlarının altta yatan otoimmün hastalığın alevlenmesi olabileceği gibi nadiren de azatiopurine bağlı hipersensitivite sendromu da olabilir. Böyle durumlarda Sweet sendromunun göz önünde bulundurulup, erken dönemde ilacın kesilmesi ve uygun tedavinin başlanması önemlidir.

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Cite This Article

CAN, G., POŞUL, E., NİĞDELİOĞLU, B., YILMAZ, B. (2020). A case of azathioprine-associated Sweet syndrome with ulcerative colitis and psoriasis. Anatolian Current Medical Journal, Cilt: 2 - Sayı: 4, 142–144. https://ajindex.com/articles/733876

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References (1)

  1. Choonhakarn C, Chaowattanapanit S. Azathioprine-induced Sweet’s syndrome and published work. J Dermatol 2013; 40: 267-71.