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Journals / Anatolian Current Medical Journal / 2021 / Cilt: 3 - Sayı: 3

Investigation of the potential use of VCAM-1, TNF-α, IL-10 and IL-6 as biomarkers of nickel exposure

Ozgur OZTAN
Vugar Ali TÜRKSOY
Serdar DENİZ
Engin TUTKUN
Pages
246–250
Publication Date
2021-07-14
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: Significant intergroup differences were observed in the levels of all inflammatory parameters such as VCAM-1, TNF-α, IL-10 and IL-6 (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Industrial and agricultural activities such as mining, smelting, and the discharging of industrial and domestic wastewater have increased the severity of heavy metal pollution in environments.
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Key Findings & Data:Methods: The study included 56 male workers exposed to nickel in coating factory (Ni-exposed group) and 44 non-exposed male workers (control group).
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Conclusion & Impact:Results: Significant intergroup differences were observed in the levels of all inflammatory parameters such as VCAM-1, TNF-α, IL-10 and IL-6 (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Nickel exposure · coating workers · inflammation parameters

Abstract

Objectives: Industrial and agricultural activities such as mining, smelting, and the discharging of industrial and domestic wastewater have increased the severity of heavy metal pollution in environments. Nickel poisoning continues to be an important occupational health problem in many branches of industry especially coating. Occupational exposure to nickel can occur through skin contact or inhalation of nickel-containing aerosols, dusts, or fumes. As a result of the toxic effect of nickel, it can cause various health problems, including respiratory and dermatological effects. Methods: The study included 56 male workers exposed to nickel in coating factory (Ni-exposed group) and 44 non-exposed male workers (control group). Vascular Cell Adhesion protein (VCAM)-1, Tumor Necrosis Factor (TNF)-α, Interleukin (IL)-10 and IL-6 levels of serum were analyzed using enzyme-linked immunosorbent assays (ELISA). Ni levels were determined using inductively coupled plasma mass spectrometry (ICP-MS) in urine samples. Results: Significant intergroup differences were observed in the levels of all inflammatory parameters such as VCAM-1, TNF-α, IL-10 and IL-6 (p

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Cite This Article

OZTAN, O., TÜRKSOY, V. A., DENİZ, S., TUTKUN, E. (2021). Investigation of the potential use of VCAM-1, TNF-α, IL-10 and IL-6 as biomarkers of nickel exposure. Anatolian Current Medical Journal, Cilt: 3 - Sayı: 3, 246–250. https://ajindex.com/articles/733826

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