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Journals / Adıyaman Üniversitesi Sağlık Bilimleri Dergisi / 2020 / Cilt: 6 - Sayı: 2

In vivo antianemic study of two species of Murva on Phenylhydrazine induced anaemia in rats

Sıçanlarda fenilhidrazin ile indüklenmiş anemi üzerine iki Murva türünün in vivo antianemik etkileri

Raju ASİRVATHAM
Aparna ANN MATHEW
Dawn V TOMY
Pages
243–247
Publication Date
2020-08-30
DOI
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⚡ TL;DR(Too Long; Didn't Read)

RBC, Haematocrit and Haemoglobin were analysed on day 0,2,7,14,21 and 28.Results: Continuous 28 days oral administration extracts raised the RBC, haemoglobin, and Haematocrit periodically in rats which were treated with PHZ.Conclusion: These plants possess antianemic activity and can be used for rapid recovery and management of anaemia.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: The present study was carried out to evaluate the antianemic effects of methanol extracts of Marsdenia tenacissima and Sansevieria roxburghiana on Phenylhydrazine (PHZ) induced anaemia in rats.Materials and Methods: PHZ (40mg/kg, i.p) injection was administered to all rats on Day 0 and Day 1 day except the group I.
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Key Findings & Data:Group II was disease control, group III to IV treated with 100, 200 mg/Kg of methanol extract of M. tenacissima whereas group V & VI received 50, 100 mg/kg of methanol extract of S. roxburghiana.
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Conclusion & Impact:RBC, Haematocrit and Haemoglobin were analysed on day 0,2,7,14,21 and 28.Results: Continuous 28 days oral administration extracts raised the RBC, haemoglobin, and Haematocrit periodically in rats which were treated with PHZ.Conclusion: These plants possess antianemic activity and can be used for rapid recovery and management of anaemia.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Murva · Marsdenia tenacissima · Sansevieria roxburghian

Abstract

Aim: The present study was carried out to evaluate the antianemic effects of methanol extracts of Marsdenia tenacissima and Sansevieria roxburghiana on Phenylhydrazine (PHZ) induced anaemia in rats.Materials and Methods: PHZ (40mg/kg, i.p) injection was administered to all rats on Day 0 and Day 1 day except the group I. Group II was disease control, group III to IV treated with 100, 200 mg/Kg of methanol extract of M. tenacissima whereas group V & VI received 50, 100 mg/kg of methanol extract of S. roxburghiana. Group VII received the higher doses of both extracts continuously from the day 3 to 28. RBC, Haematocrit and Haemoglobin were analysed on day 0,2,7,14,21 and 28.Results: Continuous 28 days oral administration extracts raised the RBC, haemoglobin, and Haematocrit periodically in rats which were treated with PHZ.Conclusion: These plants possess antianemic activity and can be used for rapid recovery and management of anaemia.

Özet

Amaç: Bu çalışma, farelerde Marsdenia tenacissima ve Sansevieria roxburghiana'nın metanol ekstraktlarının fenilhidrazin (PHZ) ile indüklenen anemi üzerindeki antianemik etkilerini değerlendirmek için yapıldı.Gereç ve Yöntem: Grup I hariç 0. ve 1. gün tüm sıçanlara PHZ (40 mg/kg, i.p) enjeksiyonu uygulandı. Grup II hastalık kontrolüdür, grup III ila IV, M. tenacissima'nın 100, 200 mg/kg metanol ekstraktı ile tedavi edilirken, grup V & VI 50, 100 mg/kg S. roxburghiana metanol ekstraktı almıştır. Grup VII, her iki ekstrakttan en yüksek dozları 3. ila 28. günler boyunca sürekli olarak aldı. Eritrosit, hematokrit ve hemoglobin 0, 2, 7, 14, 21 ve 28. günlerde analiz edildi.Bulgular: PHZ ile tedavi edilen sıçanlarda periyodik olarak 28 günlük oral metanol ekstraktlarının alınması eritrosit, hematokrit ve hemoglobini yükseltti.Sonuç: Bu bitkiler antianemik aktiviteye sahiptir ve aneminin hızlı iyileşmesi ve tedavisi için kullanılabilirler.

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Cite This Article

ASİRVATHAM, R., MATHEW, A. A., TOMY, D. V. (2020). In vivo antianemic study of two species of Murva on Phenylhydrazine induced anaemia in rats. Adıyaman Üniversitesi Sağlık Bilimleri Dergisi, Cilt: 6 - Sayı: 2, 243–247. https://ajindex.com/articles/728016

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