SavedAdd your journal

Journals / Akdeniz Tıp Dergisi / 2021 / Cilt: 7 - Sayı: 3

Is GnRH agonist protocol as effective as GnRH antagonist protocol in IVF cycles?

GnRH agonist protokolü IVFsikluslarında GnRH antagonist protokol kadar etkin midir?

Seda ŞAHİN AKER
Ruşen AYTAÇ
Pages
415–423
Publication Date
2021-09-01
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results:Agonist cycles had significantly more cases of coasting and OHSS (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective:Aim of this study is to compare effectiveness of gonadotrophin releasing hormone (GnRH) agonist in-vitro fertilization(IVF) cycles compared to GnRH antagonist IVF cycles Methods:In all, 1000 fresh cycles were used in analysis.GnRH agonist and GnRH antagonist were compared.
📊
Key Findings & Data:Primary outcome measure of the study was ongoing pregnancy rate after 12 weeks of gestation.
💡
Conclusion & Impact:Results:Agonist cycles had significantly more cases of coasting and OHSS (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:GnRH agonist protokol · GnRH antagonist protokol · in vitro fertilizasyon

Abstract

Objective:Aim of this study is to compare effectiveness of gonadotrophin releasing hormone (GnRH) agonist in-vitro fertilization(IVF) cycles compared to GnRH antagonist IVF cycles Methods:In all, 1000 fresh cycles were used in analysis.GnRH agonist and GnRH antagonist were compared. Primary outcome measure of the study was ongoing pregnancy rate after 12 weeks of gestation. Results:Agonist cycles had significantly more cases of coasting and OHSS (p

Özet

Giriş/Amaç:IVF-ET uygulanan 1000 siklusun GnRH antagonist ve agonist protokollerinin etkinliğinin karşılaştırılması amaçlanmıştır. Gereç ve Yöntemler:1000 siklus çalışmaya dahil edilmiştir,bu siklusların 283?üne agonist protokol,717?sine antagonist protokol uygulanmıştır. Her iki protokol grubu demografik özellikleri, tedavi karakteristikleri, gebelik oranları açısından karşılaştırılmıştır. Bulgular:Agonist protokol grubunda ?coasting? uygulaması ve OHSS gelişimi istatistiksel olarak yüksekti (p

🔖

Cite This Article

AKER, S. Ş., AYTAÇ, R. (2021). Is GnRH agonist protocol as effective as GnRH antagonist protocol in IVF cycles?. Akdeniz Tıp Dergisi, Cilt: 7 - Sayı: 3, 415–423. https://ajindex.com/articles/725664

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (10)

  1. Gnoth C, Godehardt D, Godehardt E, Frank-Herrmann P, Freundl G. Time to pregnancy: results of the German prospective study and impact on the management of infertility. Hum Reprod 2003;18: 1959-66
  2. Vayena E, Rowe PJ,P.Griffin PD. Current Practices and Controversies in Assisted Reproduction. WHO Press 2002;83-101
  3. Steptoe PC, Edwards RG. Reimplantation of a human embryo with subsequent tubal pregnancy. Lancet;1976;31:750-751
  4. Steptoe PC, Edwards RG. Birth after reimplantation of a human embryo. Lancet;1978;12;2:366
  5. Janssens RM, Brus L,Cahill DJ,Huirne JA,Schoemaker J,Lambalk CB. Direct ovarian effects and safety aspects of GnRH agonists and antagonists. Hum Reprod Update 2000;6:505-18
  6. ART factsheet. European Society of Human Reproduction and Embryology. 2014
  7. Daya S, Maheshwari A, Siristatidis CS, Bhattacharya S, Gibreel AF. Gonadotropin-releasing hormone agonist protocols for pituitary desensitization in in vitro fertilization and gamete intrafallopian transfer cycles. Cochrane Database Systematic Review, 2000;(2):CD001299. 8.Sunkara SK, Coomarasamy A, Faris F,Braude P, Khalaf Y. Long gonadotropn-releasing hormone agonist versus short agonist versus antagonist regimens in poorresponders undergoing in in vitro fertilization: a randomized controlled trial. Fertil Steril 2014; 101(1):147–153. 9.Albuquerque LE, Tso LO, Saconato H, Albuquerque MC, Macedo CR. Depot versus daily administration of gonadotrophin-releasing hormone agonist protocols for pituitary down regulation in assisted reproduction cycles. Cochrane Database Syst Rev. 2013;1:CD002808
  8. Assisted Reproductive Technology National Summary Report. National Center for Chronic Disease Prevention and Health Promotion.2012;1:82 (
  9. CARTR Plus 2013 Report. The Canadian Assisted Reproductive Technologies Register(CARTR). (https://cfas.ca/cartr-annual-reports.html). 12.Wang YA, Healy D, Black D, Sullivan AD. Age-specific success rate for women undertaking their first assisted reproduction technology treatment using their own oocytes in Australia, 2002– 2005. Hum Reprod. 2008; 23(7):1633-8. 13.van Loendersloot LL, van Wely M, Limpens J, Bossuyt PM, Repping S. Predictive factors in in vitro fertilization(IVF): a systematic review and meta-analysis. Hum Reprod Update. 2010;16(6):577-89. 14.Gesink Law DC, Maclehose RF, Longnecker MP. Obesity and time to pregnancy. Hum Reprod 2007;22(2):414–420
  10. Maheshwar