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Journals / Hittite Journal of Science and Engineering / 2022 / Cilt: 9 - Sayı: 3

One Step Fabrication of Hollow and Highly Flexible Polydimethylsiloxane Microneedles

Soner CAKMAK
Pages
219–224
Publication Date
2022-09-28
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Moreover, this system has the potential to be used not only for the high-throughput microfluidic fabrication of polymeric beads, but also in controlled drug delivery systems and cell encapsulation studies.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In this study, the hollow and highly flexible polydimethylsiloxane microneedles were fabricated in a one step and simple design.
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Key Findings & Data:For this purpose, a commercial dermastamping device (Dermastamp® 140 DRS) was used as a mold to obtain highly flexible PDMS microneedles containing channels.
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Conclusion & Impact:Moreover, this system has the potential to be used not only for the high-throughput microfluidic fabrication of polymeric beads, but also in controlled drug delivery systems and cell encapsulation studies.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:hollow microneedle · microfabrication · one step

Abstract

In this study, the hollow and highly flexible polydimethylsiloxane microneedles were fabricated in a one step and simple design. For this purpose, a commercial dermastamping device (Dermastamp® 140 DRS) was used as a mold to obtain highly flexible PDMS microneedles containing channels. With the proposed design, microneedles with a total height of 1500 μm, 1500 μm center-to-center spacing and 150 μm channel diameter was successfully fabricated. These data are all compatible with the dimensions and the geometry of the mold used. Then, a syringe adapter was fabricated with a 3D printer and combined with the hollow PDMS microneedle patch for the high-throughput production of alginate beads. After the adapter and the hollow PDMS microneedle patch combination was placed into the syringe pump, the mostly spherical alginate beads with a mean diameter of 2.0 ± 0.3 mm was produced. To sum up, the proposed design and fabrication scheme first offer a novel and simple strategy for the fabrication of hollow polymeric microneedles. Moreover, this system has the potential to be used not only for the high-throughput microfluidic fabrication of polymeric beads, but also in controlled drug delivery systems and cell encapsulation studies.

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Cite This Article

CAKMAK, S. (2022). One Step Fabrication of Hollow and Highly Flexible Polydimethylsiloxane Microneedles. Hittite Journal of Science and Engineering, Cilt: 9 - Sayı: 3, 219–224. https://ajindex.com/articles/671586

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