Journals / Ulusal Travma ve Acil Cerrahi Dergisi / 2022 / Cilt: 28 - Sayı: 5

Can neutrophil-lymphocyte ratio predict mortality in acute non-variceal upper gastrointestinal bleeding?

Nötrofil lenfosit oranı akut varis dışı üst gastrointestinal kanamada mortaliteyi öngörebilir mi?

Pages
626–633
Publication Date
2022-11-07
DOI
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⚡ TL;DR(Too Long; Didn't Read)

CONCLUSION: Besides the use of various scoring systems in patients with NVUGIB, we think that the use of simple hematological parameters may be appropriate and the use of these hematological parameters may be useful in the management of patients with unstable hemodynamics.

📌 3 Key Takeaways

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Objective & Hypothesis:BACKGROUND: Acute non-variceal upper gastrointestinal bleeding (NVUGIB) is one of the common gastrointestinal problems and has a high mortality, especially in patients with poor hemodynamics.
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Key Findings & Data:METHODS: Two hundred and forty-nine patients who were admitted to our clinic between January 2015 and January 2017 diagnosed with NVUGIB, and who underwent necessary examinations and follow-ups, were included in the study.
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Conclusion & Impact:CONCLUSION: Besides the use of various scoring systems in patients with NVUGIB, we think that the use of simple hematological parameters may be appropriate and the use of these hematological parameters may be useful in the management of patients with unstable hemodynamics.
🔬Design:Research Article
📍Scope:2015 Verileri
⚙️Variables:Domain Parameters

Abstract

BACKGROUND: Acute non-variceal upper gastrointestinal bleeding (NVUGIB) is one of the common gastrointestinal problems and has a high mortality, especially in patients with poor hemodynamics. Therefore, treatment and follow-up should be managed dynamically. Neutrophil-lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) are fast workable, cheap, and easy to calculate hematological parameters. We need easily accessible parameters as well as routine classifications such as Rockall score in the treatment and follow-up of NVUGIB patients, whose hemodynamics are unstable and progress with high mortality. In this study, we planned to evaluate NLR and PLR levels in patients with NVUGIB in the treatment follow-up with other scoring systems and their relationship with mortality in these patients. METHODS: Two hundred and forty-nine patients who were admitted to our clinic between January 2015 and January 2017 diagnosed with NVUGIB, and who underwent necessary examinations and follow-ups, were included in the study. The patients’ Glasgow Blacthford, Rockall Score, NLR, and PLR levels were calculated at the first admission. RESULTS: One hundred and fifty-six of the patients were male (70.6%) and the mean age of all patients was 64.5±18.0 years. After follow-up and treatment, 28 (11.2%) patients died due to bleeding. High NLR and tachycardia at the time of admission and high patient age were found to be independent risk factors affecting the long of hospital stay. High Rockall score, high NLR at admission, and hypotension at admission were shown to be independent risk factors affecting mortality. CONCLUSION: Besides the use of various scoring systems in patients with NVUGIB, we think that the use of simple hematological parameters may be appropriate and the use of these hematological parameters may be useful in the management of patients with unstable hemodynamics.

Özet

AMAÇ: Akut non varisiyel üst gastrointestinal kanama (NVUGIB) sık görülen gastrointestinal problemlerden biridir ve mortalitesi özellikle hemodinamisi kötü olan hastalarda yüksek seyretmektedir. Bu nedenle tedavi ve takibinin dinamik olarak yönetilmesi gerekmektedir. Nötrofil-lenfosit oranı (NLR), trombosit lenfosit oranı (PLR) hızlı çalışılabilir, ucuz ve hesaplanması kolay hematolojik paremetrelerdir. Özellikle hemodinamisi stabil olmayan ve yüksek mortalite ile seyreden NVUGIB hastalarının tedavi-takibinde Rockall score gibi rutin kullanılan sınıflamalar yanın da kolay ulaşılabilir parametrelere ihtiyacımız vardır. Biz bu çalışmamız da NLR ve PLR düzeylerinin NVUGIB olan hastaların tedavi-takibinde diğer skorlama sistemleri ile ve bu hastalardaki mortalite ile olan ilişkisini değerlendirmeyi planladık. GEREÇ VE YÖNTEM: Kliniğimiz de Ocak 2015–Ocak 2017 tarihleri arasında başvuran, NVUGIB tanısı konan, gerekli tetkik ve takipleri yapılan 249 hasta çalışmaya alındı. Hastaların ilk başvuru anındaki Glasgow Blacthford, Rockall score, NLR ve PLR düzeyleri hesaplandı. BULGULAR: Hastaların 156’sı erkek (%70.6) olup tüm hastaların ortalama yaşı 64.5±18.0 yıl idi. Takip ve tedavi sonrasında sonrasında kanamaya bağlı 28 (%11.2) hasta öldü. Başvuru anında NLR oranın yüksek olması, başvuru anında taşikardi olması ve hasta yaşının fazla olması hastane yatış süresinin uzun olmasını etkileyen bağımsız risk faktörleri olarak saptandı. Rockall skorunun yüksek olması, başvuru anında NLR yüksek olması, başvuru anında hipotansiyon varlığını mortaliteyi etkileyen bağımsız risk faktörleri olduğu gösterildi. TARTIŞMA: Sonuç olarak NVUGIB olan hastalarda çeşitli skorlama sistemlerinin kullanımı yanında basit hematolojik paremetrelerin kullanımının uygun olabileceğini ve hemodinamisi stabil olmayan hastaların tedavi yönetiminde bu hematolojik parametrelerin kullanımının yararlı olabileceğini düşünüyoruz.

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Cite This Article

DERTLİ, R., TOKA, B., ASIL, M., KAYAR, Y., KARAKARCAYILDIZ, A., GÖKTEPE, M. H., BIYIK, M., KONUR, S., ATASEVEN, H. (2022). Can neutrophil-lymphocyte ratio predict mortality in acute non-variceal upper gastrointestinal bleeding?. Ulusal Travma ve Acil Cerrahi Dergisi, Cilt: 28 - Sayı: 5, 626–633. https://ajindex.com/articles/655419

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