Journals / Van Tıp Dergisi / 2019 / Cilt: 26 - Sayı: 3

Demographic, Histopathological and Clinical Features of Patients with Celiac Disease

Çölyak Hastalarında Demografik, Histopatolojik ve Klinik Özellikler

Pages
363–369
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Although the classic findings such as growth retardation and chronic diarrhea may be stimulating in celiac disease, they may present with atypical findings.

📌 3 Key Takeaways

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Objective & Hypothesis:Introduction: Celiac disease (CD) is common in the world.
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Key Findings & Data:Meterial and Methods: Out of 23,250 patients admitted to our outpatient-clinic between 2009-2019, 250(1.07%) were diagnosed with CD.
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Conclusion & Impact:Conclusion: Although the classic findings such as growth retardation and chronic diarrhea may be stimulating in celiac disease, they may present with atypical findings.
🔬Design:Research Article
📍Scope:2009-2019 Verileri
⚙️Variables:Domain Parameters

Abstract

Introduction: Celiac disease (CD) is common in the world. In our study, we retrospectively evaluated the demographic, anthropometric, histopathological and clinical features of the patients followed up with the diagnosis of CD in our clinic. Meterial and Methods: Out of 23,250 patients admitted to our outpatient-clinic between 2009-2019, 250(1.07%) were diagnosed with CD. Total of 115 patients (18-65 years) were included in the study. Age, gender, onset of disease, duration of illness, family history, smoking, alcohol use, education, marital status, body mass index (BMI), waist-hip circumference and the symptoms of the patients at the time of admission were recorded. Results: Of the patients, 85 (73.9%) were female and 30 (26.1%) were male. The mean age was 33±10.6 years and the age of onset was 29.9±5.8 years. The duration of the disease was between 0-17 years and the mean duration was 4.96±3.6 years. Family history was seen in 26 (22.6%) patients. The number of smokers was 26(22.6%) and the number of patients using alcohol was one. Although the average BMI level is 22.1±4.2; 20(17.3%) patients were weak. The waist-to-hip ratio of the patients ranged from 0.63-0.98, with an average of 0.81±0.07. When the first presentation symptoms of the patients were evaluated; 83(72.2%) patients had symptoms related to gastrointestinal system (GIS), 22(19.1%) had non-GIS symptoms and 10(8.7%) had both GIS and non-GIS symptoms. Conclusion: Although the classic findings such as growth retardation and chronic diarrhea may be stimulating in celiac disease, they may present with atypical findings.

Özet

Amaç: Çölyak Hastalığı (ÇH) dünyada yaygın olarak görülmektedir. Çalışmamızda kliniğimizde ÇH tanısı ile takip ettiğimiz hastaların demografik, antropometrik, histopatolojik ve klinik özelliklerini retrospektif olarak değerlendirdik. Gereç ve Yöntemler: Polikliniğimize 2009-2019 yılları arasında başvuran toplam 23.250 hastadan 250'si (%1.07) ÇH tanısı almıştı. Bunlardan verileri eksiksiz, 18-65 yaş aralığında olan 115 hasta çalışmaya alındı. Hastalarda yaş, cinsiyet, hastalığın başlangıç yaşı, hastalık süresi, aile öyküsü varlığı, sigara,alkol kullanımı, eğitim, medeni durumu, vücut kitle indeksi (VKİ), bel-kalça çevresi ve hastaların ilk başvuru anındaki semptomları kaydedildi. Bulgular: Hastaların 85’i (%73.9) kadın, 30’u (%26.1) erkekti. Ortalama yaşları 33±10.6 yıl, hastalığın başlangıç yaşı 29.9±5.8 yıl idi. Hastalık süresi 0-17 yıl aralığında olup, ortalama 4.96±3.6 yıl idi. Aile öyküsü 26(%22.6) hastada görüldü. Sigara kullanan hasta sayısı 26(%22.6), alkol kullanan hasta sayısı birdi. Ortalama VKİ düzeyi 22.1±4.2 olmakla birlikte; hastalardan 20(%17.3)'sinin zayıf olduğu görüldü. Hastaların bel-kalça oranı 0.63-0.98 arasında değişirken, ortalama 0.81±0.07 idi. Hastaların ilk başvuru semptomları değerlendirildiğinde; 83(%72.2) hastada gastrointestinal sistem (GİS) ile ilişkili semptomlar, 22(%19.1) hastada GİS-dışı semptomlar ve 10(%8.7) hastada hem GİS hem de GİS-dışı semptomlar vardı. Sonuç: Çölyak hastalığında gelişme geriliği ve kronik ishal gibi klasik bulgular uyarıcı olmakla birlikte atipik bulgularla prezente olabileceğide unutulmamalıdır.

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Cite This Article

KAYAR, Y., SÜRMELİ, N., DERTLİ, R., BİLGİLİ, M. A., AĞIN, M., DOĞAN, N. Y. (2019). Demographic, Histopathological and Clinical Features of Patients with Celiac Disease. Van Tıp Dergisi, Cilt: 26 - Sayı: 3, 363–369. https://ajindex.com/articles/334799

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References (14)

  1. Dicke WK, Weijers HA, Van de Kamer JD. Coeliac Disease. II.The presence in wheat of a factor having a deleterious effect in cases of coeliac disease. Acta Paediatr 1953; 42(1): 34-42
  2. Husby S, Koletzko S, Korponay-Szabo I, Mearin M, Phillips A, Shamir R, et al. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease. J Pediatr Gastroenterol Nutr 2012; 54(1): 136-160
  3. Hill ID, Dirks MH, Liptak GS, Colletti RB, Fasano A, Guandalini S, et al. Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr 2005; 40(1): 1-19
  4. Farrell RJ, Kelly CP. Celiac sprue. N Engl J Med 2002; 346(3): 180-188
  5. Vilppula A, Collin P, Mäki M, Valve R, Luostarinen M, Krekelä I, et al. Undetected coeliac disease in the elderly: a biopsy-proven population-based study. Dig Liver Dis 2008; 40(10): 809-813
  6. Fasano A, Berti I, Gerarduzzi T, Not T, Colletti RB, Drago S, et al. Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study. Arch Intern Med 2003; 163(3): 286-292
  7. Hill I, Fasano A, Schwartz R, Counts D, Glock M, Horvath K. The prevalence of celiac disease in at-risk groups of children in the United States. J Pediatr 2000; 136(1): 86-90
  8. Marsh MN. Gluten, major histocompatibility complex, and the small intestine: a molecular and immunobiologic approach to the spectrum of gluten sensitivity (‘celiac sprue’). Gastroenterology 1992; 102(1): 330-354
  9. Cataldo F, Marino V. Increased prevalence of autoimmune diseases in first-degree relatives of patients with celiac disease. J Pediatr Gastroenterol Nutr 2003; 36(4): 470-473
  10. World Health Organization. (2011). Waist circumference and waist-hip ratio: report of a WHO expert consultation, Geneva, 8-11 December 2008
  11. American Diabetes Association. Standards of Medical Care in Diabetes. Diabetes Care 2015; 38: 8-67 12. Revicki DA, Wood M, Wiklund I, Crawley J. Reliability and validity of the Gastrointestinal Symptom Rating Scale in patients with gastroesophageal reflux disease. Qual Life Res 1998; 7(1): 75-83
  12. Fasano A. Where have all the American celiacs gone? Acta Paediatr Suppl 1996;412:20-24
  13. Freeman HJ. Risk factors in familial forms of celiac disease. World J Gastroenterol 2010; 16(15): 1828-1831
  14. Demirçeken FG, Kansu A, Kuloğlu Z