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Journals / Türk Nefroloji Diyaliz ve Transplantasyon Dergisi / 2010 / Cilt: 19 - Sayı: 3

The protective effect of erdostein on renal ınjury in diabetic rats

Erdosteinin diyabetik ratlarda böbrek hasarı üzerine koruyucu etkisi

Ömer Faruk KARATAŞ
Hacer HALTAŞ
Ayşe ÇARLIOĞLU
Faruk TURGUT
Rabia ALKAN
Derya AKDENİZ
Şahin Özlem BALÇIK
Ebru UZ
Pages
157–161
Publication Date
2022-11-05
DOI
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All rats were then sacrificed and kidney histopathological examinations were performed by light microscopy.RESULTS: The diabetic rats had diabetic nephropathic changes in the kidney on histological examination but the rats treated with erdostein showed significantly less histopathological changes, similar to the control group compared with the diabetic rats not treated with erdostein (p

📌 3 Key Takeaways

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Objective & Hypothesis:OBJECTİVES: Oxidative stress plays a role in the pathogenesis of diabetic nephropathy.
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Key Findings & Data:It has been reported in many studies that antioxidant therapy may decrease complications related to diabetes mellitus.
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Conclusion & Impact:All rats were then sacrificed and kidney histopathological examinations were performed by light microscopy.RESULTS: The diabetic rats had diabetic nephropathic changes in the kidney on histological examination but the rats treated with erdostein showed significantly less histopathological changes, similar to the control group compared with the diabetic rats not treated with erdostein (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

OBJECTİVES: Oxidative stress plays a role in the pathogenesis of diabetic nephropathy. It has been reported in many studies that antioxidant therapy may decrease complications related to diabetes mellitus. We aimed to evaluate the protective effects of erdostein on diabetic renal injury in diabetic rats.MATERIAL and METHODS: Thirty rats were randomly divided into 5 experimental groups (Group 1: control, group 2: erdostein, group 3: alloxan, group 4: alloxan+erdostein, and group 5: alloxan+insulin, n=6 each). Rats were made diabetic using alloxan injection intraperiteonally. Erdostein (10 mg/kg/day) orally and insulin two times a day (3 g/kg) intraperitoneally were administered for four weeks. All rats were then sacrificed and kidney histopathological examinations were performed by light microscopy.RESULTS: The diabetic rats had diabetic nephropathic changes in the kidney on histological examination but the rats treated with erdostein showed significantly less histopathological changes, similar to the control group compared with the diabetic rats not treated with erdostein (p

Özet

AMAÇ: Diyabetik nefropati patogenezinde oksidatif stres rol oynamaktadır. Birçok çalışmada antioksidan kullanımının diyabetik komplikasyonları azaltabileceği rapor edilmiştir. Bu çalışmada ratlarda diyabete bağlı gelişen böbrek hasarı üzerine erdosteinin koruyucu etkilerini gözlemlemek amaçlanmıştır.GEREÇ ve YÖNTEMLER: Otuz adet rat rastgele 5 deneysel gruba ayrıldı (Grup 1: kontrol, Grup 2: erdostein verilen grup, Grup 3; alloksan verilen grup, Grup 4: alloksan+erdostein verilen grup ve Grup 5: İnsülin+alloksan verilen grup, (her grupta n=6). Ratlar %0,9'luk sodyum klorürde çözünmüş alloksanın intraperitoneal enjeksiyonuyla diyabetik hale getirildi. Dört hafta boyunca erdostein (10 mg/kg/gün) oral yolla ve insülin günde 2 kez 3 g/kg dozunda intraperitoneal enjeksiyonla uygulandı. Sonrasında fareler kesildi. Işık mikroskopisi ile böbrekte histopatolojik değerlendirme yapıldı.BULGULAR: Diyabet geliştirilen ratlarda belirgin diyabetik nefropatiye ait değişiklikler görülürken, erdostein tedavisi alan grup, almayan grupla karşılaştırıldığında histopatolojik değişiklikler anlamlı olarak daha az oranda görüldü (p

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Cite This Article

KARATAŞ, Ö. F., HALTAŞ, H., ÇARLIOĞLU, A., TURGUT, F., ALKAN, R., AKDENİZ, D., BALÇIK, Ş. Ö., UZ, E. (2022). The protective effect of erdostein on renal ınjury in diabetic rats. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi, Cilt: 19 - Sayı: 3, 157–161. https://ajindex.com/articles/655028

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