AI Summary & Key Takeaways
AI InsightAcute choreicmovements may be seen in patients with diabetic nephropathy and intensifcation of hemodialysistreatment along with blood glucose regulation may provide improvement in this syndrome.
📌 3 Key Takeaways
Abstract
The syndrome of acute bilateral basal ganglia lesions associated with uremia presents with parkinsonism,altered mental status, and chorea in association with specifc imaging fndings in the basal ganglia. It isan uncommon syndrome seen generally in patients with diabetes mellitus and renal failure. We reporta male patient with diabetes mellitus who received hemodialysis treatment 3 days a week for 5 yearsand suffered from choreic movements developed suddenly and associated with bilateral basal ganglialesions. In the brain magnetic resonance (MR) imaging, isointense was detected in sequence T1 in thebilateral basal ganglions and hyperintense lesion was determined in T2 and FLAIR sequences. Thepatient was administered daily hemodialysis and neuroleptic treatment. After intensifed hemodialysis,his symptoms and follow-up brain MR imaging showed marked improvement. The underlyingmechanism of such lesions may be associated with metabolic, as well as vascular factors. Acute choreicmovements may be seen in patients with diabetic nephropathy and intensifcation of hemodialysistreatment along with blood glucose regulation may provide improvement in this syndrome.
Özet
Üremiileilişkiliakutbilateralbazalganglionlezyonlarıileseyredensendrom,parkinsonizm,mentaldurumdeğişikliğivekoreakliniğiileortayaçıkan,bazalganglionlardaspesifkgörüntülemebulgularısaptananbirdurumdur.Bunadirsendromçoğunlukladiyabetiküremilihastalardasaptanmaktadır.Burada5yıldırhaftada3gündüzenlihemodiyaliztedavisialan,anigelişenkoreikhareketbozukluğuolanvebilateralbazalganglionlezyonlarıileilişkilendirdiğimizbirerkekhastayısunmayaçalıştık.Beyinmanyetikrezonans(MR)incelemesindebazalganglionseviyesindeT1sekansındaizointensT2veFLAİRsekanslarındahiperintensgörüntülersaptandı.Hastayanöroleptiktedaviilebirliktegünlükhemodiyaliztedavisiuygulandı.YoğunhemodiyaliztedavisisonrasısemptomlarındavekontrolMRbulgularındabelirgingerilemesaptandı.Bulezyonlarıntemelmekanizmasımetabolikve/veyavaskülernedenlerleilişkiliolabilir.Diyabetiknefropatilihastalardagörülenakutkoreikhareketbozukluğununyoğunhemodiyaliztedavisivekanglukozregülasyonuiledüzeltilebileceğikanısındayız.