Journals / Türk Nefroloji Diyaliz ve Transplantasyon Dergisi / 2012 / Cilt: 21 - Sayı: 3

Patients with a failed renal transplant

Nakledilmiş böbreğini kaybetmiş olan hastalar

Pages
205–210
Publication Date
2022-11-04
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this review these problems were discussed.

📌 3 Key Takeaways

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Objective & Hypothesis:Renal transplantation is the best method of renal replacement therapy for patients with end-stage renal disease.
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Key Findings & Data:The controversial issues in treatment of these patients can be summarized under the headings of : 1- In which stage of allograft failure these patients should return to dialysis? 2- Which is the most appropriate renal replacement therapy after the renal allograft failure? 3- What are the main problems during dialysis practice and how should these problems be managed? 4- How should the immunosupression regimen be managed? 5- What are the indications for transplant nephrectomy? 6- What are the advantages and drawbacks of retransplantation?
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Conclusion & Impact:In this review these problems were discussed.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Renal transplantation is the best method of renal replacement therapy for patients with end-stage renal disease. On the other hand in the early or late period of transplantation, majority of patients suffer from allograft failure and return to the dialysis. These patients carry the risks of adverse effects of previous immunosuppressive therapy (i.e infections and cancers). Furthermore, worse quality of life and many limitations of dialysis result in psychological problems. The controversial issues in treatment of these patients can be summarized under the headings of : 1- In which stage of allograft failure these patients should return to dialysis? 2- Which is the most appropriate renal replacement therapy after the renal allograft failure? 3- What are the main problems during dialysis practice and how should these problems be managed? 4- How should the immunosupression regimen be managed? 5- What are the indications for transplant nephrectomy? 6- What are the advantages and drawbacks of retransplantation? In this review these problems were discussed.

Özet

Renal transplantasyon, son dönem böbrek yetmezliği (SDBY)'nin en iyi tedavisidir. Öte yandan, transplantasyondan sonra erken veya geç dönemde hastaların büyük bir kısmında graft kaybı ortaya çıkmakta ve hastalar diyalize dönmektedir. Bu hastalar immünsupresif tedavi sürecinden geçmiştir ve rutin diyaliz hastalarına kıyasla pek çok tıbbi komplikasyon (özellikle enfeksiyon ve kanser gelişimi) için riskli durumdadır. Ayrıca, transplantasyonun sağladığı kaliteli hayattan sonra diyalizin getirdiği kısıtlamalar psikolojik problemlere yol açabilir. Söz konusu problemlerin nasıl önlenebileceği veya ortaya çıktıkları zaman nasıl tedavi edileceği konusu tartışmalıdır. Bu hastaların tedavi sürecindeki belirsizliklerini şu başlıklar altında incelemek mümkündür. 1- Graft disfonksiyonunun hangi aşamasında hastalar diyalize geri dönmelidir? 2- Graft kaybı sonrasında en uygun replasman tedavisi hangisidir? 3- Bu hastalarda diyaliz süresinde ortaya çıkabilecek başlıca problemler hangileridir ve nasıl tedavi edilmelidir? 4- Hastaların almakta oldukları immünsupresif ilaçlar hangi protokole göre kesilmelidir? 5- Graft nefrektomi indikasyonları nelerdir? 6-Retransplantasyonun getiri ve götürüleri nelerdir? Bu derlemede söz konusu problemlerin çözümleri irdelenmiştir.

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Cite This Article

AKAGÜN, T., SEVER, M. Ş. (2022). Patients with a failed renal transplant. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi, Cilt: 21 - Sayı: 3, 205–210. https://ajindex.com/articles/655014

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References (13)

  1. Wolfe RA, Ashby VB, Milford EL, Ojo AO, Ettenger RE, Agodoa LY, Held PJ, Port FK: Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation and recipients of a fi rst cadaveric transplant. N Engl J Med 1999
  2. 1730 2. Laupacis A, Keown P, Pus N, Krueger H, Ferguson B, Wong C, Muirhead N: A study of the quality of life and cost-utility of renal transplantation. Kidney Int 1996
  3. 242 3. Collins AJ, Kasiske B, Herzog C: Excerpts from the United States Renal Data System 2001 annual data report. Am J Kidney Dis 2001
  4. 38 (Suppl.6): 1-57 4. Cecka JM: The UNOS renal transplant registry. Clin Transplant 2001
  5. 18 5. Collins AJ, Foley R, Herzog C, Chavers B, Gilbertson D, Ishani A, Kasiske B, Liu J, Mau LW, McBean M, Murray A, St Peter W, Xue J, Fan Q, Guo H, Li Q, Li S, Li S, Peng Y, Qiu Y, Roberts T, Skeans M, Snyder J, Solid C, Wang C, Weinhandl E, Zaun D, Zhang R, Arko C, Chen SC, Dalleska F, Daniels F, Dunning S, Ebben J, Frazier E, Hanzlik C, Johnson R, Sheets D, Wang X, Forrest B, Constantini E, Everson S, Eggers P, Agodoa L: Excerpts from the United States Renal Data System 2007 annual data report. Am J Kidney Dis 2008
  6. 320 6. Hariharan S, Johnson CP, Bresnahan BA, Taranto SE, McIntosh MJ, Stablein D: Improved graft survival after renal transplantation in the United States, 1988 to 1996. N Engl J Med 2000
  7. 612 7. Langone AJ, Chuang P: The management of the failed renal allograft: An enigma with potential consequences. Semin in Dialysis 2005
  8. 18 (3): 185-187 8. Hakım RM, Lazarus JM: Initiation of dialysis. J Am Soc Nephrol 1995
  9. 1328 9. Cooper BA, Branley P, Bulfone L, Collins JF, Craig JC, Fraenkel MB, Harris A, Johnson DW, Kesselhut J, Li JJ, Luxton G, Pilmore A, Tiller DJ, Harris DC, Pollock CA
  10. IDEAL Study: A randomized controlled trial of early versus late initiation of dialysis. NEJM 2010
  11. 619 10. NKF/KDOQI hemodialysis and peritoneal dialysis adequacy guidelines, 2006. [www.kdoqi.org] 11. Arias M, Escallada R, de Francisco AL, Rodrigo E, Fernández- Fresnedo G, Setién MA, Piñera C, Ruiz JC, Herráez I, Cotorruelo J: Return to dialysis after renal transplantation. Which would be the best way? Kidney Int Suppl 2002
  12. 88 12. Sleiman J, Garrigue V, Vetromile F, Mourad G: Return to dialysis after renal allograft loss: Is dialysis treatment initiated too late? Transplant Proc 2007
  13. 2598 13. Mariat C, Alamartine E, Afi ani A, Thibaudin L, Laurent B, Bertho