Journals / Turkish Journal of Pharmaceutical Sciences / 2021 / Cilt: 18 - Sayı: 4

Physicochemical Evaluation and Antibacterial Activity of Massularia acuminata Herbal Toothpaste

Massularia acuminata Herbal Diş Macununun Antibakteriyel Aktivitesi ve Fizikokimyasal Değerlendirmesi

Pages
101–106
Publication Date
2022-11-06
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Incorporating this extract in toothpaste formulation will satisfactorily maintain oral hygiene, which is desirable to prevent dental caries and periodontal diseases.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Oral hygiene, an integral part of the body’s general well-being, should be maintained to prevent dental problems.
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Key Findings & Data:This study was conducted to incorporate the ethanol extract of Massularia acuminata twigs in a formulation of herbal toothpaste and evaluate its antibacterial activity compared with a commercially available herbal toothpaste against two dental pathogens, namely, Staphylococcus aureus and Streptococcus mutans.
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Conclusion & Impact:Incorporating this extract in toothpaste formulation will satisfactorily maintain oral hygiene, which is desirable to prevent dental caries and periodontal diseases.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: Oral hygiene, an integral part of the body’s general well-being, should be maintained to prevent dental problems. This study was conducted to incorporate the ethanol extract of Massularia acuminata twigs in a formulation of herbal toothpaste and evaluate its antibacterial activity compared with a commercially available herbal toothpaste against two dental pathogens, namely, Staphylococcus aureus and Streptococcus mutans. Materials and Methods: The content of dried M. acuminata twig was extracted using ethanol and used in the formulation of toothpaste containing 1%, 2%, 3%, 4%, and 5% M. acuminata extract. The sensory and physicochemical properties of the toothpaste were evaluated. The agar well diffusion method was used to evaluate the antibacterial susceptibility of the toothpaste against S. aureus and S. mutans. Data were analyzed using One-Way analysis of variance and Student’s t-test. Results: All toothpastes were smooth and sweet and smelled pleasant. They all had good retention ability on the bristles of toothbrush and had a pH range of 7.18-7.83. The toothpastes of the extracts of different concentration demonstrated antibacterial activities against the test organisms. The antibacterial activity of the formulated toothpastes increased significantly with an increase in the extract concentration. F5 that contained 5% extract showed the highest activity, with an inhibition zone of 19.30±0.17 mm and 12.60±0.52 mm against S. aureus and S. mutans, respectively, even when compared with the commercially available herbal toothpaste. Conclusion: The incorporation of the M. acuminata extract in the formulation of herbal toothpaste prevented the growth of S. aureus and S. mutans. Incorporating this extract in toothpaste formulation will satisfactorily maintain oral hygiene, which is desirable to prevent dental caries and periodontal diseases.

Özet

Amaç: Vücudun genel iyilik halinin bir bileşeni olan oral hijyenin dental sorunları önlemek için idamesi sağlanmalıdır. Bu çalışma Massularia acuminata dallarının etanol ekstresinin bir bitkisel diş macunu formülasyonuna dahil etmek ve iki dental patojen olan Staphylococcus aureus and Streptococcus mutans’a karşı antibakteriyel aktivetisini ticari olarak var olan bir diş macunuyla karşılaştırarak değerlendirmek için yapılmıştır. Gereç ve Yöntemler: Kurutulmuş M. acuminata dalının içeriği etanol kullanılarak ekstre edilmiştir ve %1, %2, %3, %4 ve %5 M. acuminata ekstresi içeren diş macunu formülasyonlarında kullanılmıştır. Diş macununun duyusal ve fizikokimyasal özellikleri değerlendirilmiştir. Diş macununun S. aureus ve S. mutans’a karşı antibakteriyel duyarlılığını değerlendirmek için agar kuyusu difüzyon yöntemi kullanılmıştır. Veriler One-Way analizi ve Student t-testi kullanılarak analiz edilmiştir. Bulgular: Tüm diş macunları pürüzsüz ve tatlıydı ve hoş kokuyordu. Hepsinin diş fırçası kılları üzerinde iyi bir tutma kabiliyeti vardı ve pH aralığı 7,18-7,83 idi. Farklı konsantrasyondaki ekstraktların diş macunları, test organizmalarına karşı antibakteriyel aktivite göstermiştir. Formüle edilmiş diş macunlarının antibakteriyel aktivitesi, ekstrakt konsantrasyonundaki artışla önemli ölçüde artmıştır. %5 ekstrakt içeren F5, ticari olarak satılan bitkisel diş macunu ile karşılaştırıldığında bile, sırasıyla S. aureus ve S. mutans’a karşı 19,30±0,17 mm ve 12,60±0,52 mm’lik bir inhibisyon bölgesi ile en yüksek aktiviteyi göstermiştir.

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Cite This Article

ADELEYE, O. A., ADEBOWALE, M., BAMIRO, O., AKPOTU, M., DAODU, J., SODEINDE, M. A. (2022). Physicochemical Evaluation and Antibacterial Activity of Massularia acuminata Herbal Toothpaste. Turkish Journal of Pharmaceutical Sciences, Cilt: 18 - Sayı: 4, 101–106. https://ajindex.com/articles/654562

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