Journals / Akdeniz Tıp Dergisi / 2019 / Cilt: 5 - Sayı: 3

Potential Pitfalls in Liquid-based Preparations of Patients with Chronic Lymphocytic Thyroiditis / Hashimoto Thyroiditis

Kronik Lenfositik Tiroidit/Hashimoto Tiroiditli Hastalarının Sıvı Bazlı Preparatlarındaki Potansiyel Tuzaklar

Pages
467–475
Publication Date
2022-11-05
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Nuclear contour irregularity was detected in all papillary carcinoma cases.Conclusion: We think that cleaner background in cytological material prepared with the liquidbased cytology method allows us to evaluate the nuclear detail more easily, thereby increasing the diagnostic accuracy of malignant lesions, in patients with CLT/HT while the decrease of colloid and inflammatory cells causes interpretation of cases as belonging to the intermediate cytological category and results in unnecessary surgery

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Our study aim to determine the cytomorphologic features that cause diagnostic difficulties with the liquid-based cytology method applied to cytological materials obtained by fine needle aspiration to evaluate thyroid lesions of chronic lymphocytic thyroiditis / Hashimoto thyroiditis CLT/HT patients.Material and Methods: This study retrospectively included diagnostic fine needle aspiration biopsies from the nodules of 70 CLT/HT patients who had undergone surgery for a suspicious nodule or cosmetic surgery between 2014 and May 2018.
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Key Findings & Data:Cytomorphological features of liquid-based preparations were evaluated and compared with the histological diagnoses.Results: Fifty-two percent of our cases were reported as benign, 38% were in the indeterminate cytological category atypia of undetermined significance/follicular lesion of undetermined significance, follicular neoplasm/suspicious for follicular neoplasm, suspicious for malignancy and 10% had malignant cytology.
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Conclusion & Impact:Nuclear contour irregularity was detected in all papillary carcinoma cases.Conclusion: We think that cleaner background in cytological material prepared with the liquidbased cytology method allows us to evaluate the nuclear detail more easily, thereby increasing the diagnostic accuracy of malignant lesions, in patients with CLT/HT while the decrease of colloid and inflammatory cells causes interpretation of cases as belonging to the intermediate cytological category and results in unnecessary surgery
🔬Design:Review & Systematic Survey
📍Scope:2014 Verileri
⚙️Variables:Sure Path · Sıvı bazlı sitoloji · Tiroid ince iğne aspirasyon

Abstract

Objective: Our study aim to determine the cytomorphologic features that cause diagnostic difficulties with the liquid-based cytology method applied to cytological materials obtained by fine needle aspiration to evaluate thyroid lesions of chronic lymphocytic thyroiditis / Hashimoto thyroiditis CLT/HT patients.Material and Methods: This study retrospectively included diagnostic fine needle aspiration biopsies from the nodules of 70 CLT/HT patients who had undergone surgery for a suspicious nodule or cosmetic surgery between 2014 and May 2018. Histological and cytological diagnoses of the cases were reviewed. Cytomorphological features of liquid-based preparations were evaluated and compared with the histological diagnoses.Results: Fifty-two percent of our cases were reported as benign, 38% were in the indeterminate cytological category atypia of undetermined significance/follicular lesion of undetermined significance, follicular neoplasm/suspicious for follicular neoplasm, suspicious for malignancy and 10% had malignant cytology. Reactive lymphoid cells were observed in 84% of the cases and colloid in 50% of the cases. Intranuclear pseudoinclusion was present in 69% of the cases. Nuclear contour irregularity was detected in all papillary carcinoma cases.Conclusion: We think that cleaner background in cytological material prepared with the liquidbased cytology method allows us to evaluate the nuclear detail more easily, thereby increasing the diagnostic accuracy of malignant lesions, in patients with CLT/HT while the decrease of colloid and inflammatory cells causes interpretation of cases as belonging to the intermediate cytological category and results in unnecessary surgery

Özet

Amaç: Kronik lenfositik tiroidit/Hashimoto tiroidit KLT/HT tanılı hastalarının, tiroid lezyonlarını değerlendirmek amacıyla ince iğne aspirasyon ile elde edilen sitoloji materyallerine uygulanan sıvı bazlı sitoloji yönteminin tanı güçlüğü yaratan sitomorfolojik özellikleri saptamak.Gereç ve Yöntemler: Retrospektif olarak bu çalışmaya 2014 ve Mayıs 2018 yılları arasında şüpheli nodül veya kozmetik amaçlı cerrahi operasyon geçiren 70 KLT/HT tanılı hastanın nodülüne ait tanısal ince iğne aspirasyon biyopsisi dahil edildi. Olguların histolojik ve sitolojik tanıları yeniden gözden geçirildi. Sıvı bazlı preparatlarındaki sitomorfolojik özellikler incelendi ve histolojik tanılarıyla karşılaştırıldı.Bulgular: Olgularımızın %52’si benign, %38’i ara sitolojik kategori önemi belirsiz atipi/önemi belirsiz foliküler lezyon, foliküler neoplazi/foliküler neoplazi şüphesi ve malignite şüpheli ve %10 malign sitoloji olarak raporlandı. Reaktif lenfoid hücre olguların %84’ünde az miktarda izlenirken kolloid ise olguların %50’inde saptandı. Papiller karsinom tanılı olguların %69’unda intranükleer psödoinklüzyon ve tamamında nükleer kontur düzensizliği mevcuttu.Sonuç: Sıvı bazlı sitoloji yöntemi uygulanan sitolojik materyallerde, kolloid ve inflamatuvar hücrelerinin azalması olguların ara sitolojik kategori olarak yorumlanmasına ve gereksiz cerrahiye neden olurken temiz zemin sayesinde nükleer detayı daha rahat değerlendirmemizi sağlayarak KLT/HT’li hastalarda malign lezyonların tanılabilirliğini artırdığını düşünmekteyiz

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Cite This Article

SADULLAHOĞLU, C., ALPARSLAN, A. Ş., YILDIRIM, H. T., YILDIRIM, Ş., NERGİZ, D., SEZER, C., ÇEKİÇ, B. (2022). Potential Pitfalls in Liquid-based Preparations of Patients with Chronic Lymphocytic Thyroiditis / Hashimoto Thyroiditis. Akdeniz Tıp Dergisi, Cilt: 5 - Sayı: 3, 467–475. https://ajindex.com/articles/648378

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References (8)

  1. Baser H, Ozdemir D, Cuhaci N, Aydin C, Ersoy R, Kilicarslan A, Cakir B. Hashimoto’s thyroiditis does not affect ultrasonographical, cytological, and histopathological features in patients with papillary thyroid carcinoma. Endocrine Pathology 2015;26:356- 64. Guarino V, Castellone MD, Avilla E, Melillo RM. Thyroid cancer and inflammation. Molecular and Cellular Endocrinology 2010;321:94-102.
  2. Chui MH, Cassol CA, Asa SL, Mete O. Follicular epithelial dysplasia of the thyroid: Morphological and immunohistochemical characterization of a putative preneoplastic lesion to papillary thyroid carcinoma in chronic lymphocytic thyroiditis. Virchows Archiv 2013;462:557-63. Hasan G. Tümöral olmayan tiroid patolojileri. İçinde: Dizbay Pak S, Sökmensüer C, ed. Endokrin organ patolojisi. 1. basım. İzmir: O’Tıp Kitabevi, 2017:33-56.
  3. Harvey AM, Truong LD, Mody DR. Diagnostic pitfalls of Hashimoto’s/lymphocytic thyroiditis on fine-needle aspirations and strategies to avoid overdiagnosis. Acta Cytol 2012;56(4):352-60.
  4. Elsheikh TM, Cochand-Priolllet B, Won Hong S, Sidawy MK. Benign. In: Ali SZ, Cibas ES, eds. The bethesda system for reporting thyroid cytopathology. 2nd ed. Cham: Springer Press, 2018:19-48.
  5. Duncan LD, Forrest L, Law WM, Hubbard E, Stewart LE. Evaluation of thyroid fine‐needle aspirations: Can ThinPrep be used exclusively to appropriately triage patients having a thyroid nodule? Diagnostic Cytopathology 2011;39(5):341-8. Cochand‐Priollet B, Prat JJ, Polivka M, Thienpont L, Dahan H, Wassef M, Guillausseau PJ. Thyroid fine needle aspiration: The morphological features on ThinPrep® slide preparations. Eighty cases with histological control. Cytopathology 2003;14:343-9.
  6. Chong Y, Ji S-J, Kang CS, Lee EJ. Can liquid-based preparation substitute for conventional smear in thyroid fine-needle aspiration? A systematic review based on meta-analysis. Endocrine Connections 2017;6:817-29.
  7. Sahin D, Yilmazbayhan D, Firat P, Hacisalihoglu U, Kirimlioglu S, Celenk E, Arslan E. Comparison of conventional cytology and SurePath in split thyroid fine needle aspiration materials. Cytopathology 2017;28:291- 8. Fadda G, Rossi ED. Liquid-based cytology in fine-needle aspiration biopsies of the thyroid gland. Acta cytologica 2011;55:389-400.
  8. Lee JS, Choi H-S, Park IA, Ryu HS. Liquid-based fine needle aspiration biopsy of papillary thyroid carcinoma: logistic regression analysis with conventional and new cytomorphologic features. Acta Cytologica 2013;57:233- 40. Chong Y, Baek KH, Kim JY, Kim