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Journals / Viral Hepatitis Journal / 2021 / Cilt: 27 - Sayı: 3

Distribution of Hepatitis C Virus Genotypes: 18-Year Experience in an Academic Center

Hepatit C Virüs Genotip Dağılımı: Akademik Bir Merkez, 18 Yıllık Deneyim

Kurtulus Buruk
NESE KAKLIKKAYA
Esra Özkaya
Faruk Aydın
Ilknur Tosun
Irmak Baran
Pages
118–123
Publication Date
2022-11-06
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Genotype 1b was detected in 63.2% of patients under

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Hepatitis C virus (HCV) is an important public health problem worldwide.
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Key Findings & Data:Materials and Methods: Following HCV genotype and subtype sequence analysis, the sequence and the reference sequences were compared with the “line probe assay” method or the multiplex amplification methods of 5’UTR and NS5B or only NS5B.
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Conclusion & Impact:Genotype 1b was detected in 63.2% of patients under
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: Hepatitis C virus (HCV) is an important public health problem worldwide. This study examined long-term changes in distribution of HCV genotypes s in HCV-RNA-positive patients in a large population. Materials and Methods: Following HCV genotype and subtype sequence analysis, the sequence and the reference sequences were compared with the “line probe assay” method or the multiplex amplification methods of 5’UTR and NS5B or only NS5B. Results: In the study, HCV-RNA positive 670 patients undergoing genotyping were included. Genotype 1 was detected in 603 patients (90.0%), genotype 3 in 45 (6.7%), genotype 2 in 12 (1.8%), genotype 4 in 6 (0.9%), combined genotypes 1 and 2 in 2 (0.3%), and genotypes 1 and 4 in 2 (0.3%). Genotypes 5, 6, 7 and 8 were not observed in this study. The most dominant subtypes by years were genotype 1b (82.8%) and genotype 3a (4.5%). Genotype 1b was detected in 63.2% of patients under

Özet

Amaç: Hepatit C virüsü (HCV) kronik hepatit, siroz, hepatosellüler karsinom gibi hastalıklara yol açması nedeniyle önemli bir halk sağlığı sorunudur. Bu çalışmada, geniş bir popülasyondaki HCV-RNA pozitif hastalarda, HCV genotip dağılımında uzun bir dönemdeki değişimin incelenmesi amaçlandı. Gereç ve Yöntemler: HCV genotip ve subtipleri dizi analizi sonrasında dizinin referans dizilerle karşılaştırılması; “line probe assay” yöntemiyle veya 5’UTR ve NS5B’nin veya sadece NS5B’nin multipleks amplifikasyonu yöntemlerinden biriyle gerçekleştirildi. Bulgular: Çalışmada HCV-RNA pozitif olup genotiplendirme yapılan toplam 670 hasta yer aldı. Hastaların 603’ünde (%90,0) genotip 1, 45’inde (%6,7) genotip 3, 12’sinde (%1,8) genotip 2 ve 6’sında (%0,9) genotip 4, 2’sinde (%0,3) genotip 1 ve 3 ve yine 2’sinde (%0,3) genotip 1 ve 4 birlikteliği tespit edildi. Çalışmada genotip 5, 6, 7 ve 8’e rastlanmadı. Yıllara göre en baskın subtip genotip 1b (%82,8) idi. İkinci en sık saptanan subtip ise genotip 3a (%4,5) idi. Genotip 1b

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Cite This Article

Buruk, K., KAKLIKKAYA, N., Özkaya, E., Aydın, F., Tosun, I., Baran, I. (2022). Distribution of Hepatitis C Virus Genotypes: 18-Year Experience in an Academic Center. Viral Hepatitis Journal, Cilt: 27 - Sayı: 3, 118–123. https://ajindex.com/articles/646314

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