Journals / Viral Hepatitis Journal / 2020 / Cilt: 26 - Sayı: 2

Diagnostic Performance of Non-invasive Fibrosis Indexes in Hepatitis B Related Fibrosis

Hepatit B İlişkili Fibrosiste Non-invaziv Fibrozis Göstergelerinin Tanısal Performansı

Pages
78–84
Publication Date
2022-11-06
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

The diagnostic performance of the non-invasive markerswas defined as the AUROC value of ≥0.9 as excellent, 0.9> AUROC≥0.8 as good, 0.8> AUROC ≥0.7 as moderate and AUROC

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: The aim of this study was to evaluate the diagnosticperformance of non-invasive fibrosis markers [AST to platelet ratio(APRI), Fibrosis Index based on four factors (FIB-4) İndex, AST/platelet/GGT/Alpha-fetoprotein (AFP) Index (APGA), FI, Fibro-quotient(FibroQ), AST/ALT ratio (AAR), GGT/Platelet ratio (GPR), Platelet-agephosphatase-AFP-AST (PAPAS) and S-Index] in chronic hepatitis b(CHB) patients.Materials and Methods: Treatment naive CHB patients whounderwent liver biopsy were screened.
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Key Findings & Data:The diagnostic efficacy of non-invasivefibrosis indicators for significant fibrosis (≥F3) and cirrhosis (≥F5) wasevaluated.
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Conclusion & Impact:The diagnostic performance of the non-invasive markerswas defined as the AUROC value of ≥0.9 as excellent, 0.9> AUROC≥0.8 as good, 0.8> AUROC ≥0.7 as moderate and AUROC
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: The aim of this study was to evaluate the diagnosticperformance of non-invasive fibrosis markers [AST to platelet ratio(APRI), Fibrosis Index based on four factors (FIB-4) İndex, AST/platelet/GGT/Alpha-fetoprotein (AFP) Index (APGA), FI, Fibro-quotient(FibroQ), AST/ALT ratio (AAR), GGT/Platelet ratio (GPR), Platelet-agephosphatase-AFP-AST (PAPAS) and S-Index] in chronic hepatitis b(CHB) patients.Materials and Methods: Treatment naive CHB patients whounderwent liver biopsy were screened. Four hundred seventeenpatients were included in the study. Fibrosis stage was reevaluatedaccording to ISHAK score. The diagnostic efficacy of non-invasivefibrosis indicators for significant fibrosis (≥F3) and cirrhosis (≥F5) wasevaluated. The diagnostic performance of the non-invasive markerswas defined as the AUROC value of ≥0.9 as excellent, 0.9> AUROC≥0.8 as good, 0.8> AUROC ≥0.7 as moderate and AUROC

Özet

Amaç: Bu çalışmada kronik hepatit B (KHB) hastalarında non-invaziv fibrozis göstergelerinin [AST/trombosit oranı (APRI), dört faktöre dayalı fibrozis İndeksi (FIB-4), AST/platelet/GGT/alfa-fetoprotein (AFP) indeks (APGA), FI, fibro-quotient (FibroQ), AST / ALT oranı (AAR), GGT/trombosit oranı (GPR), Trombosit-Yaş-fosfataz-AFPAST (PAPAS) ve S-index] tanısal performanslarının değerlendirilmesi amaçlanmıştır. Gereç ve Yöntemler: Karaciğer biyopsisi yapılan tedavi naiv KHB tanılı hastalar tarandı. Çalışmaya 417 hasta dahil edildi. Fibrozis evreleri ISHAK skoruna göre tekrar değerlendirildi. Non-invaziv göstergelerin anlamlı fibrozis (≥F3) ve siroz (≥F5) için diagnostik etkinliği değerlendirildi. Non-invaziv göstergelerin tanısal performansı AUROC değeri ≥0,9 ise mükemmel, 0,9> AUROC ≥0,8 ise iyi, 0,8> AUROC ≥0,7 ise orta ve AUROC

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Cite This Article

KAHRAMAN, R., ÖZDİL, K., ÇALIŞKAN, Z., SAYAR, S., ATALAY, R., ÇAKMAK, Ş., AYRANCI, G., KÜRBÜZ, K., ÖZTÜRK, O., DEMİRDAĞ, H., ADALI, G., DOĞANAY, H. L. (2022). Diagnostic Performance of Non-invasive Fibrosis Indexes in Hepatitis B Related Fibrosis. Viral Hepatitis Journal, Cilt: 26 - Sayı: 2, 78–84. https://ajindex.com/articles/646361

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