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Journals / Türk Uyku Tıbbı Dergisi / 2020 / Cilt: 7 - Sayı: 1

Mean Platelet Volume in Patients With Obstructive SleepApnea Syndrome and Concurrent Hypertension andDiabetes Mellitus

Obstüktif Uyku Apneli ve Eşlik Eden Hipertansiyonlu ve Diabetes Mellituslu Hastalarda Ortalama Trombosit Hacmi

Ayşegül ALTINTOP GEÇKİL
Çiğdem FIRAT KOCA
Pages
5–9
Publication Date
2022-11-06
DOI
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Results: There were significant differences between the groups in desaturation index, Body Mass index, AHI, minimum oxygen saturation, and arousal (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Obstructive Sleep Apnea syndrome (OSAS) is a common disorder affecting especially middle-aged adults.
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Key Findings & Data:Patients whose AHI was 5-15 decided as mild, 15-30 as moderate, and above 30 was severe group.
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Conclusion & Impact:Results: There were significant differences between the groups in desaturation index, Body Mass index, AHI, minimum oxygen saturation, and arousal (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Obstructive Sleep Apnea syndrome (OSAS) is a common disorder affecting especially middle-aged adults. Elevated platelet activation and aggregation have a close relationship with cardiovascular complications. Mean platelet volume (MPV) is a marker of platelet activation. The influence of OSAS on platelet activation is not fully understood subject. Materials and Methods: One hundred ninety-two patients who were included in this study examined retrospectively with polysomnography. The Apnea-hypopnea index (AHI) above five was accepted as OSAS. The AHI under five was decided as control group. The OSAS group was categorized into three groups according to AHI values. Patients whose AHI was 5-15 decided as mild, 15-30 as moderate, and above 30 was severe group. The control group consist of 28 patients (14.6%), mild OSAS group consist of 31 patients (16.1%), moderate OSAS group consist of 42 patients (21.9%), and severe OSAS group consist of 91 patients (47.6%). The medical and sleep histories, demographic data, cardiovascular and metabolic histories, drug use of the patients were retrospectively examined. Laboratory analyze consisted of a routine blood evaluation. Hypertension and diabetes mellitus history also investigated. Results: There were significant differences between the groups in desaturation index, Body Mass index, AHI, minimum oxygen saturation, and arousal (p

Özet

Amaç: Obstrüktif Uyku Apne sendromu (OUAS) özellikle orta yaşerişkinleri etkileyen yaygın bir hastalıktır. Artmış platelet aktivasyon veagregasyonu ile kardiyovasküler komplikasyonlar arasında yakın birilişki mevcuttur. Ortalama trombosit hacmi, platelet aktivasyonununbir belirtecidir. OUAS’nin platelet aktivasyonu üzerine etkisi tam olarakanlaşılamamış bir konudur.Gereç ve Yöntem: Bu çalışmaya dahil edilen 192 hasta polisomnografi ileretrospektif olarak incelendi. Apne-hipopne indeksi (AHİ) beşin üzerindeolması OUAS olarak kabul edildi. AHİ beşin altında olanlar kontrol grubuolarak kararlaştırıldı. OUAS grubu apne-hipopne değerine göre üç grubaayrıldı. AHİ 5-15 arası olanlar hafif, 15-30 arası olanlar orta ve 30 üzeriolanlar ağır grup olarak ayrıldı. Kontrol grubu 28 hastadan (%14,6),hafif obstrüktif uyku apne grubu 31 hastadan (%16,1), orta obstrüktifuyku apne grubu 42 hastadan (%21,9) ve ağır obstrüktif uyku apnegrubu 91 hastadan (%47,6) oluşuyordu. Hastaların medikal ve uykuhikayeleri, demografik verileri, kardiyovasküler ve metabolik hikayesi, ilaçkullanımı retrospektif olarak incelendi. Laboratuar incelemesi rutin kandeğerlendirmesinden oluşuyordu. Hipertansiyon ve diabetes mellitushikayesi de ayrıca araştırıldı.Bulgular: Gruplar arasında Desatürasyon indeksi, Vücut Kitle indeksi,AHİ, minimum oksijen satürasyonu ve arousal arasında anlamlı farkmevcuttu (p

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Cite This Article

GEÇKİL, A. A., KOCA, Ç. F. (2022). Mean Platelet Volume in Patients With Obstructive SleepApnea Syndrome and Concurrent Hypertension andDiabetes Mellitus. Türk Uyku Tıbbı Dergisi, Cilt: 7 - Sayı: 1, 5–9. https://ajindex.com/articles/643287

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