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Journals / Türk Patoloji Dergisi / 2013 / Cilt: 29 - Sayı: 3

Melanositik olmayan deri kanserlerinde tümöral ve peritümöral alanlardaki büyüme hormonu reseptörü, insülin benzeri büyüme faktörü-1 reseptörü ve insülin benzeri büyüme faktörü bağlayıcı protein-3’ün karşılaştırılması

Comparison of growth hormone receptor, igf-1r and ıgfbp-3 between tumoral and non-tumoral areas in non-melanoma skin cancers

Özay GÖKÖZ
Tülin AKAN
Gül ERKİN
Özge GÜNDÜZ
Pages
185–192
Publication Date
2022-11-05
DOI
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⚡ TL;DR(Too Long; Didn't Read)

However, a significantly higher expression of insulin-like growth factor-1 receptor was observed in tumoral areas of squamous cell carcinoma (P

📌 3 Key Takeaways

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Objective & Hypothesis:Objective:A relationship between the pathogenesis of some cancers and growth hormone, insulin-like growth factor-1 and insulin-like growth factors binding protein-3 has been shown.
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Key Findings & Data:Our aim was to evaluate the expression of growth hormone receptor, insulin-like growth factor-1 receptor and insulin-like growth factors binding protein-3 in actinic keratosis, basal cell carcinoma and squamous cell carcinoma, and to compare the expression patterns of tumoral areas with normal epidermis and skin appendages.
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Conclusion & Impact:However, a significantly higher expression of insulin-like growth factor-1 receptor was observed in tumoral areas of squamous cell carcinoma (P
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective:A relationship between the pathogenesis of some cancers and growth hormone, insulin-like growth factor-1 and insulin-like growth factors binding protein-3 has been shown. Our aim was to evaluate the expression of growth hormone receptor, insulin-like growth factor-1 receptor and insulin-like growth factors binding protein-3 in actinic keratosis, basal cell carcinoma and squamous cell carcinoma, and to compare the expression patterns of tumoral areas with normal epidermis and skin appendages. Material and Method:The formalin-fixed, paraff in-embedded tissues of 40 patients which were diagnosed as 15 actinic keratosis, 15 basal cell carcinoma and 15 squamous cell carcinoma were analyzed for growth hormone receptor, insulin-like growth factor-1 receptor and insulin-like growth factors binding protein-3 with the immunohistochemical method using the streptavidin-biotin-peroxidase technique. Results:There was no diff erence between tumoral areas of actinic keratosis, basal cell carcinoma an d squamous cell carcinoma in expression of growth hormone receptor and insulin-like growth factors binding protein-3 (P>0.05). However, a significantly higher expression of insulin-like growth factor-1 receptor was observed in tumoral areas of squamous cell carcinoma (P

Özet

Amaç:Büyüme hormonu, insülin benzeri büyüme faktörü-1 ve insülin benzeri büyüme faktörü bağlayıcı protein-3 bazı kanserlerin patogenezi ile ilişkili bulunmuştur. Aktinik keratoz, bazal hücreli karsinom veya skuamoz hücreli karsinomda büyüme hormon reseptörü, insülin benzeri büyüme faktörü-1 reseptörü ve insülin benzeri büyüme faktörü bağlayıcı protein-3 ekspresyonunun belirlenmesi ve tümöral alanların ekspresyon özelliklerinin normal epidermis ve deri ekleriyle karşılaştırılması amaçlandı. Gereç ve Yöntem:Kırk hastaya ait formaldehitle fikse edilmiş, parafine gömülmüş aktinik keratoz (n=15), bazal hücreli karsinom (n=15) ve skuamoz hücreli karsinom (n=15) tanısı almış doku örnekleri strep- tavidin-biotin-peroksidaz tekniği kull anılarak immünohistokimyasal metodla büyüme hormon reseptörü, insülin benzeri büyüme faktörü-1 reseptörü ve insülin benzeri büyüme faktörü bağlayıcı protein-3 varlığı açı sından incelendi. Bulgular:Çalışmamızda, aktinik kerato z, bazal hücreli karsinom ve skuamoz hücreli karsinomun tümöral alanları arasında büyüme hormon reseptörü ve insülin benzeri büyüme faktörü bağlayıcı protein-3 ekspresyonu açısından anlamlı fark bulunmazken (P>0.05); insülin benzeri büyüme faktörü-1 reseptörü ile skuamoz hücreli karsinomda tümöral alanlarda anlamlı olarak daha fazla ekspresyon izlendi (P

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Cite This Article

GÖKÖZ, Ö., AKAN, T., ERKİN, G., GÜNDÜZ, Ö. (2022). Melanositik olmayan deri kanserlerinde tümöral ve peritümöral alanlardaki büyüme hormonu reseptörü, insülin benzeri büyüme faktörü-1 reseptörü ve insülin benzeri büyüme faktörü bağlayıcı protein-3’ün karşılaştırılması. Türk Patoloji Dergisi, Cilt: 29 - Sayı: 3, 185–192. https://ajindex.com/articles/640654

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