Journals / Türk Otorinolarengoloji Arşivi / 2015 / Cilt: 53 - Sayı: 4

The Relationship between Th1/Th2 Balance and 1α, 25-Dihydroxyvitamin D3 in Patients with Allergic Rhinitis

Alerjik Rinitli Hastalarda Th1/Th2 Dengesi ile 1α, 25-Dihidroksivitamin D3 Arasındaki İlişki

Pages
139–143
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: In IgE, IL-4, IL-10, IFN-γ, and 1α,25-dihydroxyvitamin D3 levels (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:With regard to the correlation between T helper1/T helper2 (Th1/Th2) cell balance and 1α,25-dihydroxyvitamin D3 , active metabolite of vitamin D, we studied Th1/Th2 cell balance by measuring levels of the cytokines interleukin (IL)-4, IL-10 and interferon-gamma (IFN-γ), which are important for immune response of patients with allergic rhinitis.
📊
Key Findings & Data:Methods: Thirty adult patients diagnosed with allergic rhinitis (study group) and 40 healthy volunteers (control group) are examined in the research.
💡
Conclusion & Impact:Results: In IgE, IL-4, IL-10, IFN-γ, and 1α,25-dihydroxyvitamin D3 levels (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

With regard to the correlation between T helper1/T helper2 (Th1/Th2) cell balance and 1α,25-dihydroxyvitamin D3 , active metabolite of vitamin D, we studied Th1/Th2 cell balance by measuring levels of the cytokines interleukin (IL)-4, IL-10 and interferon-gamma (IFN-γ), which are important for immune response of patients with allergic rhinitis. Methods: Thirty adult patients diagnosed with allergic rhinitis (study group) and 40 healthy volunteers (control group) are examined in the research. IFN-γ, IL-4, IL-10, and total immunoglobulin E (IgE) levels from serum samples and vitamin D3 levels from plasma were determined in all patients. Results: In IgE, IL-4, IL-10, IFN-γ, and 1α,25-dihydroxyvitamin D3 levels (p

Özet

Bu çalışmada alerjik riniti olan hastalarda immun yanıtta rol oynayan İnterlökin-4 (IL-4), İnterlökin-10 (IL-10) ve İnterferon-gamma (IFN-?) sitokinlerinin dü- zeylerini belirleyerek T helper 1/T helper 2 (Th1/Th2) hücre dengesininin araştırılması ve bu denge ile D vitamininin aktif metaboliti olan 1?,25-dihidroksivitamin D3 arasındaki ilişkinin belirlenmesi amaçlandı. Yöntemler: Çalışma alerjik riniti olan 30 erişkin hasta (çalışma grubu) ve 40 sağlıklı gönüllü (kontrol grubu) üzerinde yapıldı. Bütün hastaların ve kontrol grubunun serum örneklerinde IFN-?, IL-4, IL-10 ve total İmmünglobulin E (IgE) seviyeleri, plazma örneklerinde ise D vitamini düzeyleri ölçüldü. Bulgular: Çalışma ve kontrol grubu kıyaslandığında; IgE, IL-4, IL-10, IFN-? ve D vitamini değerleri arasında istatistiksel olarak anlamlı bir farklılık tespit edildi (p

🔖

Cite This Article

GÜNGÖR, H., YALÇIN, Ş., KARLIDAĞ, T., ÖZKARA, Ş., İLHAN, N., KELEŞ, E. (2022). The Relationship between Th1/Th2 Balance and 1α, 25-Dihydroxyvitamin D3 in Patients with Allergic Rhinitis. Türk Otorinolarengoloji Arşivi, Cilt: 53 - Sayı: 4, 139–143. https://ajindex.com/articles/640318

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. König K, Klemens C, Eder K, San Nicoló M, Becker S, Kramer MF, et al. Cytokine profiles in nasal fluid of patients with seasonal or persistent allergic rhinitis. Allergy Asthma Clin Immunol 2015
  2. [CrossRef ] 2. Bauchau V, Durham SR. Prevalence and rate of diagnosis of allergic rhinitis in Europe. Eur Respir J 2004
  3. [CrossRef ] 3. Bauchau V, Durham SR. Epidemiological characterization of the intermittent and persistent types of allergic rhinitis. Allergy 2005
  4. [CrossRef ] 4. Searing DA, Leung DY. Vitamin D in atopic dermatitis, asthma and allergic diseases. Immunol Allergy Clin North Am 2010
  5. [CrossRef ] 5. Baeke F, Takiishi T, Korf H, Gysemans C, Mathieu C. Vitamin D. Modulator of the immune system. Curr Opin Pharmacol 2010
  6. [CrossRef ] 6. Sandhu MS, Casale TB. The role of vitamin D in asthma. Ann Allergy Asthma Immunol 2010
  7. [CrossRef ] 7. Erkkola M, Kaila M, Nwaru BI, Kronberg-Kippilä C, Ahonen S, Nevalainen J, et al. Maternal vitamin D intake during pregnancy is inversely associated with asthma and allergic rhinitis in 5-year-old children. Clin Exp Allergy 2009
  8. [CrossRef ] 8. Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A, et al. Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy 2008
  9. Suppl 86: 8-160. [CrossRef ] 9. Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald M, et al. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J 2008
  10. [CrossRef ] 10. Ozkara S, Keles E, Ilhan N, Gungor H, Kaygusuz I, Alpay HC. The relationship between Th1/Th2 balance and 1,25-dihydroxyvitamin D₃ in patients with nasal polyposis. Eur Arch Otorhinolaryngol 2012
  11. [CrossRef ] 11. Boonstra A, Barrat FJ, Crain C, Heath VL, Savelkoul HF, O’Garra A. 1,25-dihydroxyvitamin D3 has a direct effect on naive CD4+ T cells to enhance the development of Th2 cells. J Immunol 2001
  12. [CrossRef ] 12. Goetz DW. Vitamin D treatment of idiopathic itch, rash, and urticaria/angioedema. Allergy Asthma Proc 2010
  13. [CrossRef ] 13. Wisniewski JA, Borish L. Novel Cytokines and cytokine-producing T cell in allergic disorders. Allergy Asthma Proc 2011
  14. [CrossRef ] 14. Broide DH. Allergic rhinitis: Pathophysiology. Allergy Astma Proc 2010
  15. [CrossRef ] 15. Staeva-Vieira TP, Freedman LP. 1