Journals / Türk Otolarengoloji Arşivi / 2004 / Cilt: 42 - Sayı: 1

In vitro activity of some topical ear drops against middle ear pathogens

Bazı tropikal otik damlaların orta kulak patojenlerine in vitro etkileri

Pages
30–33
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Among all bacteria, ciprofloxacin was found the most effective.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Topical otic antibiotics are often used in otitis externa and chronic otitis media.
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Key Findings & Data:This study investigated the in vitro effectiveness of the drops containing rifampicin (10 mg/ml), gentamicin (5 mg/ml), ciprofloxacin (3.0 mg/ml), which can be used topically in draining ears.
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Conclusion & Impact:Among all bacteria, ciprofloxacin was found the most effective.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Topical otic antibiotics are often used in otitis externa and chronic otitis media. This study investigated the in vitro effectiveness of the drops containing rifampicin (10 mg/ml), gentamicin (5 mg/ml), ciprofloxacin (3.0 mg/ml), which can be used topically in draining ears. Thus, we used meticillin resistant Staphylococcus aureus (MRSA), Proteus spp, Pseudomonas aeruginosa, Enterobacter spp and Escherichia coli strains was isolated from draining ears of the patients referred to our polyclinic. Twenty strains from each bacteria were included in the study. The zone of inhibition brought about by the drops on these bacterium plaques was measured. The average zone diameter was obtained by dividing the sum of zone diameters from 20 bacteria species to 20. Among all bacteria, ciprofloxacin was found the most effective.

Özet

Topikal otik antibiyotikler otitis eksterna ve kronik otitis mediada sıklıkla kullanılırlar. Bu çalışmamızda akıntılı kulaklarda topikal olarak kullanılabilen rifampisin (10 mg/ml), gentamisin (5 mg/ml) ve siprofloksasin (3.0 mg/ml) içeren damlaların in vitro etkinliği araştırıldı. Bu amaçla KBB polikliniğine başvuran akıntılı kulaklardan izole edilen metisilin dirençli Staphylococcus aureus (MRSA), Proteus spp, Pseudomonas aeruginosa, Enterobacter spp, Escherichia coli suşları kullanıldı. Damlaların bu bakteri plakları üzerinde oluşturduğu inhibisyon zon çapları ölçülerek değerlendirme yapıldı. Ortalama zon çapı, test edilen 20 bakteri suşunun oluşturduğu zon çapları toplamının 20’ye bölünmesiyle elde edildi. Tüm bakteriler gözönüne alındığında siprofloksasin en etkili olarak bulundu.

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Cite This Article

YİĞİT, N., AYYILDIZ, A., AKTAŞ, A. E., ÜÇÜNCÜ, H., YAZGI, H. (2022). In vitro activity of some topical ear drops against middle ear pathogens. Türk Otolarengoloji Arşivi, Cilt: 42 - Sayı: 1, 30–33. https://ajindex.com/articles/640060

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