SavedAdd your journal

Journals / Türk Oftalmoloji Dergisi / 2003 / Cilt: 33 - Sayı: 3-1

The influence of menopause and combined hormone replacement therapy on ocular blood flow

Menopoz ve kombine hormon replasman tedavisinin oküler kan akımı üzerine etkisi

Ebru TOKER
İhsan AKPINAR
Özlem YENİCE
Haluk KAZOKOĞLU
Pages
469–474
Publication Date
2022-11-04
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In the central retinal artery, premenopausal women showed higher PSV (p=0.002 and p=0.006, respectively) and EDV (both p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Purpose: In this study, we investigated the hemodynamic changes in ophthalmic and central retinal arteries with color Doppler imaging to assess the effect of menopause and combined hormone replacement therapy on ocular blood flow. .
📊
Key Findings & Data:Methods: Twenty-two premenopausal women, 30 postmenopausal women, who had never received hormone replacement therapy and 32 postmenopausal women, who had been receivingcombined hormone replacement therapy (0.625 mg conjugated estrogen and 2.5 mg medroxy-progesterone) with a mean duration of 4 years (range, 1 to 12 years) participated this study.
💡
Conclusion & Impact:In the central retinal artery, premenopausal women showed higher PSV (p=0.002 and p=0.006, respectively) and EDV (both p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: In this study, we investigated the hemodynamic changes in ophthalmic and central retinal arteries with color Doppler imaging to assess the effect of menopause and combined hormone replacement therapy on ocular blood flow. . Methods: Twenty-two premenopausal women, 30 postmenopausal women, who had never received hormone replacement therapy and 32 postmenopausal women, who had been receivingcombined hormone replacement therapy (0.625 mg conjugated estrogen and 2.5 mg medroxy-progesterone) with a mean duration of 4 years (range, 1 to 12 years) participated this study. Color Doppler imaging was used to determine peak systolic velocity (PSV), end-diastolic velocity (EDV) and resistive index (RI) in the ophthalmic and central retinal arteries. Results: Premenopausal women had significantly higher PSV in the ophthalmic artery when compared with either group of postmenopausal women (p=0.02 and p=0.006, respectively). EDV and the RI in this vessel were each similar in the three groups of women (p>0.05). In the central retinal artery, premenopausal women showed higher PSV (p=0.002 and p=0.006, respectively) and EDV (both p

Özet

Amaç: Bu çalışmada, menopozun ve kombine hormon replasman tedavisinin oküler kan akımı üzerine etkilerini araştırmak amacıyla renkli Doppler görüntüleme yöntemi ile oftalmik ve santral retinal arterlerin hemodinamik değişiklikleri incelendi. Yöntem: Çalışmaya, menopoz öncesi dönemde olan 22 kadın, hormon replasman tedavisi almayan 30 menopozlu kadın ve ortalama 4 yıldır (aralık, l ile 12 yıl) kombine hormon replasman tedavisi almakta (0.625 mg konjuge östrojen + 2.5 mg medroksiprogesteron asetat) olan 32 menopozlu kadın dahil edildi. Renkli Doppler görüntüleme yöntemi ile oftalmik ve santral retinal arterlerin maksimum sistolik hızları (MSH), diastol sonu hızları (DSH) ve rezistif indeksleri (Rİ) ölçüldü. Bulgular: Menopoz öncesi dönemdeki kadınların oftalmik arter MSH değerleri her iki menopozal gruptan anlamlı olarak yüksekti (sırasıyla, p=0.02 ve p=0.006), DSH ve Rİ değerleri üç grup arasında anlamlı farklılık göstermemekteydi (p>0.05). Hormon replasman tedavisi alan ve almayan menopozlu kadınlarla karşılaştırıldığında, menopoz öncesi dönemdeki kadınların santral retinal arter MSH (sırasıyla, p=0.002 ve p=0.006) ve DSH'larının (her iki p

🔖

Cite This Article

TOKER, E., AKPINAR, İ., YENİCE, Ö., KAZOKOĞLU, H. (2022). The influence of menopause and combined hormone replacement therapy on ocular blood flow. Türk Oftalmoloji Dergisi, Cilt: 33 - Sayı: 3-1, 469–474. https://ajindex.com/articles/638968

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. Speroff L, Glass RH, Kase NG: Menopause and postme- nopausal hormone replacement therapy. In: Clinical gyne- cologic endocrinology. Baltimore. Williams & Wilkins 1994; 583-649
  2. Messerli FH, Garavaglia GE, Schmieder RE, Sundgaard- Riise K, Nunez BD, Amodeo C: Disparate cardiovascular findings in men and women with essential hypertension. Ann Intern Med 1987; 107: 158-161
  3. Kalin MF, Zumoff B: Sex hormones and coronary disea- se: a review of the clinical studies. Steroids. 1990; 55: 350-352
  4. Stampfer MJ, Colditz GA, Willett WC, Manşon JE, Ros- ner B, Speizer FE, Hennekens CH: Postmenopausal estro- gen therapy and cardiovascular disease: ten-year follow- up from the nurses' health study. N Engl J Med 1991; 325: 756-762
  5. Riedel M, Oeltermann A, Mugge A, Creutzig A, Raffen- beul WW, Lichtlen P: Vascular responses to 17-oestradiol in postmenopausal women. Eur J Clin Invest 1995; 25: 44-47
  6. Pirhonen JP, Vuento MH, Makinen JI, Salmi TA: Long- term effects of hormone replacement therapy on the ute- rus and on uterine circulation. Am J Obstet Gynecol 1993; 168:620-623
  7. Gangar KF, Vyas S, Witehead M, Crook D, Meire H, Campbell S: Pulsatility index in internal carotid artery in relation to transdermal oestrodiol and time since menopa- use. Lancet 1991; 338: 839-842
  8. Penotti M, Nencioni T, Gabrielli L, Farina M, Castiglioni E, Polvani F: Blood flow variations in internal carotid and middle cerebral arteries induced by postmenopausal hor- mone replacement therapy. Am J Obstet Gynecol 1993; 169: 1226-1232
  9. Sacks FM, Gerhard M, Walsh BW: Sex hormones, lipop- roteins, and vascular reactivity. Curr Opin Lipidol 1995; 6: 161-165. 10. van Baal WM, Kenemans P, Stehouwer CDA, Peters-Muller ERA, van Vugt JMG, van der Mooren M: Sequentially combined hormone replacement therapy reduces impedance to flow within the uterine and central retinal arteries in healthy postmenopausal women. Am J Obstet Gynecol 1999; 181: 1365-1373
  10. Harris-Yitzhak M, Harris A, Ben-Refael Z, Zarfati D, Garzozi HJ, Martin BJ: Estrogen-replacement therapy: ef- fects on retrobulbar hemodynamics. Am J Ophthalmol 2000; 129: 623-628
  11. Atilla H, Aslanpençe A, Batıoğlu F, Eryılmaz T, Aytaç S, Özcan H, Kurtay G: Effect of hormone replacement the- rapy on ocular hemodynamics in postmenopausal women. Eur J Ophthalmol 2001; 11: 277-280
  12. Hayreh S, Zimmerman MB, Podhajsky P, Alward WLM. Nocturnal arterial hypotension and its role in optic nerve head and ocular ischemic disorders. Am J